Downregulation of messenger RNA levels for ribosomal proteins in differentiating HL-60 cells
After differentiation induction in HL-60 cells by treatment with retinoic acid, phorbol ester, or dimethyl sulfoxide strong downregulation of the steady state mRNA level of the putative protein No. 3 of the large ribosomal subunit (rpL3) was observed. Downregulation was also observed in other hemopo...
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| Veröffentlicht in: | Experimental cell research 1992-05, Vol.200 (1), p.145-148 |
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| creator | Mailhammer, Reinhard Szöts, Hannelore Bönisch, Jürgen Dörmer, Peter |
| description | After differentiation induction in HL-60 cells by treatment with retinoic acid, phorbol ester, or dimethyl sulfoxide strong downregulation of the steady state mRNA level of the putative protein No. 3 of the large ribosomal subunit (rpL3) was observed. Downregulation was also observed in other hemopoietic human cell lines, although to a lesser extent. Four ribosomal proteim mRNAs were compared in their degree of downregulation after differentiation induction or actinomycin D treatment. The comparatively fast response of rpL3 mRNA observed could indicate a regulatory function of rpL3 protein. |
| doi_str_mv | 10.1016/S0014-4827(05)80082-5 |
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Downregulation was also observed in other hemopoietic human cell lines, although to a lesser extent. Four ribosomal proteim mRNAs were compared in their degree of downregulation after differentiation induction or actinomycin D treatment. The comparatively fast response of rpL3 mRNA observed could indicate a regulatory function of rpL3 protein.</description><identifier>ISSN: 0014-4827</identifier><identifier>EISSN: 1090-2422</identifier><identifier>DOI: 10.1016/S0014-4827(05)80082-5</identifier><identifier>PMID: 1563482</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Cell Differentiation - genetics ; Cell Line ; Down-Regulation ; Hematopoietic Stem Cells ; Humans ; Ribosomal Proteins - analysis ; Ribosomal Proteins - genetics ; RNA, Messenger - analysis ; RNA, Messenger - biosynthesis ; Tretinoin - pharmacology</subject><ispartof>Experimental cell research, 1992-05, Vol.200 (1), p.145-148</ispartof><rights>1992 Academic Press, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c275t-6d7b5dd17ab43e0c9e0a7e543fc2161d2915bd6b1a4671106119db7b02102d183</citedby><cites>FETCH-LOGICAL-c275t-6d7b5dd17ab43e0c9e0a7e543fc2161d2915bd6b1a4671106119db7b02102d183</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0014-4827(05)80082-5$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1563482$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mailhammer, Reinhard</creatorcontrib><creatorcontrib>Szöts, Hannelore</creatorcontrib><creatorcontrib>Bönisch, Jürgen</creatorcontrib><creatorcontrib>Dörmer, Peter</creatorcontrib><title>Downregulation of messenger RNA levels for ribosomal proteins in differentiating HL-60 cells</title><title>Experimental cell research</title><addtitle>Exp Cell Res</addtitle><description>After differentiation induction in HL-60 cells by treatment with retinoic acid, phorbol ester, or dimethyl sulfoxide strong downregulation of the steady state mRNA level of the putative protein No. 3 of the large ribosomal subunit (rpL3) was observed. Downregulation was also observed in other hemopoietic human cell lines, although to a lesser extent. Four ribosomal proteim mRNAs were compared in their degree of downregulation after differentiation induction or actinomycin D treatment. The comparatively fast response of rpL3 mRNA observed could indicate a regulatory function of rpL3 protein.</description><subject>Cell Differentiation - genetics</subject><subject>Cell Line</subject><subject>Down-Regulation</subject><subject>Hematopoietic Stem Cells</subject><subject>Humans</subject><subject>Ribosomal Proteins - analysis</subject><subject>Ribosomal Proteins - genetics</subject><subject>RNA, Messenger - analysis</subject><subject>RNA, Messenger - biosynthesis</subject><subject>Tretinoin - pharmacology</subject><issn>0014-4827</issn><issn>1090-2422</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1LxDAQxYMo67r6Jwg5iR6qM9kmbU8i6ycsCn7chNA20yXSJpp0Ff97u67o0dPAvDfzHj_G9hGOEVCdPABgmqS5yA5BHuUAuUjkBhsjFJCIVIhNNv61bLOdGF9gMOWoRmyEUk2H_Zg9n_sPF2ixbMveesd9wzuKkdyCAr-_PeMtvVMbeeMDD7by0Xdly1-D78m6yK3jxjYNBXK9HT64Bb-eJwp4TW0bd9lWU7aR9n7mhD1dXjzOrpP53dXN7Gye1CKTfaJMVkljMCurdEpQFwRlRjKdNrVAhUYUKCujKixTlSGCQixMlVUgEITBfDphB-u_Q6-3JcVedzauGpSO_DLqTOQFppgORrk21sHHGKjRr8F2ZfjUCHpFVX9T1StkGqT-pqrlcLf_E7CsOjJ_V2uMg3661gdU9G4p6FhbcjUZG6jutfH2n4QvPP2GbQ</recordid><startdate>199205</startdate><enddate>199205</enddate><creator>Mailhammer, Reinhard</creator><creator>Szöts, Hannelore</creator><creator>Bönisch, Jürgen</creator><creator>Dörmer, Peter</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199205</creationdate><title>Downregulation of messenger RNA levels for ribosomal proteins in differentiating HL-60 cells</title><author>Mailhammer, Reinhard ; Szöts, Hannelore ; Bönisch, Jürgen ; Dörmer, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c275t-6d7b5dd17ab43e0c9e0a7e543fc2161d2915bd6b1a4671106119db7b02102d183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Cell Differentiation - genetics</topic><topic>Cell Line</topic><topic>Down-Regulation</topic><topic>Hematopoietic Stem Cells</topic><topic>Humans</topic><topic>Ribosomal Proteins - analysis</topic><topic>Ribosomal Proteins - genetics</topic><topic>RNA, Messenger - analysis</topic><topic>RNA, Messenger - biosynthesis</topic><topic>Tretinoin - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mailhammer, Reinhard</creatorcontrib><creatorcontrib>Szöts, Hannelore</creatorcontrib><creatorcontrib>Bönisch, Jürgen</creatorcontrib><creatorcontrib>Dörmer, Peter</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental cell research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mailhammer, Reinhard</au><au>Szöts, Hannelore</au><au>Bönisch, Jürgen</au><au>Dörmer, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Downregulation of messenger RNA levels for ribosomal proteins in differentiating HL-60 cells</atitle><jtitle>Experimental cell research</jtitle><addtitle>Exp Cell Res</addtitle><date>1992-05</date><risdate>1992</risdate><volume>200</volume><issue>1</issue><spage>145</spage><epage>148</epage><pages>145-148</pages><issn>0014-4827</issn><eissn>1090-2422</eissn><abstract>After differentiation induction in HL-60 cells by treatment with retinoic acid, phorbol ester, or dimethyl sulfoxide strong downregulation of the steady state mRNA level of the putative protein No. 3 of the large ribosomal subunit (rpL3) was observed. 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| ispartof | Experimental cell research, 1992-05, Vol.200 (1), p.145-148 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Cell Differentiation - genetics Cell Line Down-Regulation Hematopoietic Stem Cells Humans Ribosomal Proteins - analysis Ribosomal Proteins - genetics RNA, Messenger - analysis RNA, Messenger - biosynthesis Tretinoin - pharmacology |
| title | Downregulation of messenger RNA levels for ribosomal proteins in differentiating HL-60 cells |
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