Regulation of Akt-dependent cell survival by Syk and Rac

Interleukin-2 (IL-2) prevents cell apoptosis and promotes survival, but the involved mechanisms have not been completely defined. Although phosphatidylinositide 3-kinase (PI 3-kinase) has been implicated in IL-2–mediated survival mechanisms, none of the 3 chains of the IL-2 receptor (IL-2R) expresse...

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Veröffentlicht in:	Blood 2003-01, Vol.101 (1), p.236-244
Hauptverfasser:	Jiang, Kun, Zhong, Bin, Ritchey, Connie, Gilvary, Danielle L., Hong-Geller, Elizabeth, Wei, Sheng, Djeu, Julie Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blood Cells Cell Line Cell Survival Enzyme Inhibitors - pharmacology Enzyme Precursors - antagonists & inhibitors Enzyme Precursors - metabolism Enzyme Precursors - physiology Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunobiology Interleukin-2 - pharmacology Intracellular Signaling Peptides and Proteins Killer Cells, Natural - cytology Killer Cells, Natural - metabolism Modulation of the immune response (stimulation, suppression) Phosphatidylinositol 3-Kinases - metabolism Protein-Serine-Threonine Kinases - metabolism Protein-Serine-Threonine Kinases - physiology Protein-Tyrosine Kinases - antagonists & inhibitors Protein-Tyrosine Kinases - metabolism Protein-Tyrosine Kinases - physiology Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins - physiology Proto-Oncogene Proteins c-akt Signal Transduction Syk Kinase
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