Regulation of glycogen synthase by glucose and glycogen: A possible role for AMP-activated protein kinase

We report here use of human myoblasts in culture to study the relationships between cellular glycogen concentrations and the activities of glycogen synthase (GS) and AMP-activated protein kinase (AMPK). Incubation of cells for 2 h in the absence of glucose led to a 25% decrease in glycogen content a...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2003, Vol.52 (1), p.9-15
Hauptverfasser:	HALSE, Reza, FRYER, Lee G. D, MCCORMACK, James G, CARLING, David, YEAMAN, Stephen J
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - pharmacology Aminoimidazole Carboxamide - analogs & derivatives Aminoimidazole Carboxamide - pharmacology AMP-Activated Protein Kinases Biological and medical sciences Carbohydrates Cells, Cultured Diabetes Enzyme Activation - drug effects Enzymes Fundamental and applied biological sciences. Psychology Glucose Glucose - deficiency Glucose - pharmacology Glucose metabolism Glycogen Glycogen - pharmacology Glycogen Phosphorylase - antagonists & inhibitors Glycogen Synthase - antagonists & inhibitors Glycogen Synthase - metabolism Glycogen synthesis Humans Hydrogen Peroxide - pharmacology Indoles - pharmacology Insulin Isoenzymes - metabolism Kinases Metabolisms and neurohumoral controls Multienzyme Complexes - physiology Myoblasts - enzymology Phosphorylation Protein-Serine-Threonine Kinases - physiology Proteins Ribonucleotides - pharmacology Synthesis Vertebrates: anatomy and physiology, studies on body, several organs or systems
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