Paget's disease of the oesophagus associated with mucous gland carcinoma of the lower oesophagus
Aim: To report a rare case of oesophageal Paget's disease and its rarer combination with submucosal gland carcinoma of the lower oesophagus. Methods and results: A 74‐year‐old Saudi female was admitted with the complaint of dysphagia. Endoscopic examination showed an ulcerated tumour at the g...
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| Veröffentlicht in: | Histopathology 2003-01, Vol.42 (1), p.61-65 |
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| creator | Haleem, A Kfoury, H Al Juboury, M Al Husseini, H |
| description | Aim: To report a rare case of oesophageal Paget's disease and its rarer combination with submucosal gland carcinoma of the lower oesophagus.
Methods and results: A 74‐year‐old Saudi female was admitted with the complaint of dysphagia. Endoscopic examination showed an ulcerated tumour at the gastro–oesophageal junction. Initial biopsy showed an undifferentiated carcinoma with pagetoid spread in the oesophageal stratified squamous epithelium. Oesophago‐gastrectomy specimen showed a lobulated, poorly differentiated mucous gland carcinoma at the gastro–oesophageal junction. The tumour showed focal acinar differentiation and obvious cancerization of the submucosal glands, somewhat similar to the breast lobular carcinoma in situ. One of the isolated and cancerized submucosal glands also showed carcinoma in situ of its duct. Oesophageal surface epithelium showed extensive pagetoid spread, both over and away from the main tumour. The pagetoid tumour cells showed selective positivity for cytokeratin 7, cytokeratin Cam 5.2, BerEP4 and to a lesser extent for CEA.
Conclusions: As far as we know, this is the fifth case report of oesophageal Paget's disease and the first report of its association with the underlying mucous gland carcinoma. |
| doi_str_mv | 10.1046/j.1365-2559.2003.01514.x |
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Methods and results: A 74‐year‐old Saudi female was admitted with the complaint of dysphagia. Endoscopic examination showed an ulcerated tumour at the gastro–oesophageal junction. Initial biopsy showed an undifferentiated carcinoma with pagetoid spread in the oesophageal stratified squamous epithelium. Oesophago‐gastrectomy specimen showed a lobulated, poorly differentiated mucous gland carcinoma at the gastro–oesophageal junction. The tumour showed focal acinar differentiation and obvious cancerization of the submucosal glands, somewhat similar to the breast lobular carcinoma in situ. One of the isolated and cancerized submucosal glands also showed carcinoma in situ of its duct. Oesophageal surface epithelium showed extensive pagetoid spread, both over and away from the main tumour. The pagetoid tumour cells showed selective positivity for cytokeratin 7, cytokeratin Cam 5.2, BerEP4 and to a lesser extent for CEA.
Conclusions: As far as we know, this is the fifth case report of oesophageal Paget's disease and the first report of its association with the underlying mucous gland carcinoma.</description><identifier>ISSN: 0309-0167</identifier><identifier>EISSN: 1365-2559</identifier><identifier>DOI: 10.1046/j.1365-2559.2003.01514.x</identifier><identifier>PMID: 12493026</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Adenocarcinoma, Mucinous - chemistry ; Adenocarcinoma, Mucinous - pathology ; Adenocarcinoma, Mucinous - surgery ; Aged ; Biological and medical sciences ; Biomarkers, Tumor - analysis ; Carcinoma - pathology ; Carcinoma in Situ - pathology ; Carcinoma, Small Cell - pathology ; Diagnosis, Differential ; Esophageal Neoplasms - chemistry ; Esophageal Neoplasms - pathology ; Esophageal Neoplasms - surgery ; Esophagogastric Junction - pathology ; Esophagus ; Female ; Gastrectomy ; Gastric Mucosa - pathology ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Immunohistochemistry ; Lymphoma - pathology ; Medical sciences ; Melanoma - pathology ; mucous gland carcinoma ; Neoplasm Proteins - analysis ; Neoplasms, Multiple Primary - chemistry ; Neoplasms, Multiple Primary - pathology ; Neoplasms, Multiple Primary - surgery ; oesophageal carcinoma ; oesophageal Paget's disease ; Paget Disease, Extramammary - chemistry ; Paget Disease, Extramammary - pathology ; Paget Disease, Extramammary - surgery ; Paget's disease ; Treatment Outcome ; Tumors</subject><ispartof>Histopathology, 2003-01, Vol.42 (1), p.61-65</ispartof><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4334-c96a8d63fe0156d0d613a63594eb2397ddb1f9cb1eed0085093d8ae14f25525e3</citedby><cites>FETCH-LOGICAL-c4334-c96a8d63fe0156d0d613a63594eb2397ddb1f9cb1eed0085093d8ae14f25525e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1365-2559.2003.01514.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1365-2559.2003.01514.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,4024,27923,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14629188$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12493026$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Haleem, A</creatorcontrib><creatorcontrib>Kfoury, H</creatorcontrib><creatorcontrib>Al Juboury, M</creatorcontrib><creatorcontrib>Al Husseini, H</creatorcontrib><title>Paget's disease of the oesophagus associated with mucous gland carcinoma of the lower oesophagus</title><title>Histopathology</title><addtitle>Histopathology</addtitle><description>Aim: To report a rare case of oesophageal Paget's disease and its rarer combination with submucosal gland carcinoma of the lower oesophagus.
Methods and results: A 74‐year‐old Saudi female was admitted with the complaint of dysphagia. Endoscopic examination showed an ulcerated tumour at the gastro–oesophageal junction. Initial biopsy showed an undifferentiated carcinoma with pagetoid spread in the oesophageal stratified squamous epithelium. Oesophago‐gastrectomy specimen showed a lobulated, poorly differentiated mucous gland carcinoma at the gastro–oesophageal junction. The tumour showed focal acinar differentiation and obvious cancerization of the submucosal glands, somewhat similar to the breast lobular carcinoma in situ. One of the isolated and cancerized submucosal glands also showed carcinoma in situ of its duct. Oesophageal surface epithelium showed extensive pagetoid spread, both over and away from the main tumour. The pagetoid tumour cells showed selective positivity for cytokeratin 7, cytokeratin Cam 5.2, BerEP4 and to a lesser extent for CEA.
Conclusions: As far as we know, this is the fifth case report of oesophageal Paget's disease and the first report of its association with the underlying mucous gland carcinoma.</description><subject>Adenocarcinoma, Mucinous - chemistry</subject><subject>Adenocarcinoma, Mucinous - pathology</subject><subject>Adenocarcinoma, Mucinous - surgery</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Carcinoma - pathology</subject><subject>Carcinoma in Situ - pathology</subject><subject>Carcinoma, Small Cell - pathology</subject><subject>Diagnosis, Differential</subject><subject>Esophageal Neoplasms - chemistry</subject><subject>Esophageal Neoplasms - pathology</subject><subject>Esophageal Neoplasms - surgery</subject><subject>Esophagogastric Junction - pathology</subject><subject>Esophagus</subject><subject>Female</subject><subject>Gastrectomy</subject><subject>Gastric Mucosa - pathology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Lymphoma - pathology</subject><subject>Medical sciences</subject><subject>Melanoma - pathology</subject><subject>mucous gland carcinoma</subject><subject>Neoplasm Proteins - analysis</subject><subject>Neoplasms, Multiple Primary - chemistry</subject><subject>Neoplasms, Multiple Primary - pathology</subject><subject>Neoplasms, Multiple Primary - surgery</subject><subject>oesophageal carcinoma</subject><subject>oesophageal Paget's disease</subject><subject>Paget Disease, Extramammary - chemistry</subject><subject>Paget Disease, Extramammary - pathology</subject><subject>Paget Disease, Extramammary - surgery</subject><subject>Paget's disease</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><issn>0309-0167</issn><issn>1365-2559</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1PGzEQhq2qVQm0f6HaC-W0i7_Wax84VBEEEGorkYqj69izidPdbLA3Svj3eJsAPfY0lv08npkXoYzggmAuzpcFYaLMaVmqgmLMCkxKwovdOzR6fXiPRphhlWMiqiN0HOMSY1IxSj-iI0K5YpiKEfr908yhP4uZ8xFMhKyrs36RCsRuvTDzTcxMjJ31pgeXbX2_yNqN7dL1vDErl1kTrF91rXkRm24L4R_9E_pQmybC50M9Qb-uLqfj6_zux-Rm_O0ut5wxnlsljHSC1ZBWEQ47QZgRrFQcZpSpyrkZqZWdEQCHsSyxYk4aILxOu9IS2An6uv93HbrHDcRetz5aaNKUkMbVFZVSCsUTKPegDV2MAWq9Dr414UkTrId09VIPIeohRD2kq_-mq3dJ_XLosZm14N7EQ5wJOD0AJlrT1MGsrI9vHBdUESkTd7Hntr6Bp_8eQF_f3A-n5Od738cedq--CX-0qFhV6ofvEz2l1eRhOr7Xt-wZ-bqlRA</recordid><startdate>200301</startdate><enddate>200301</enddate><creator>Haleem, A</creator><creator>Kfoury, H</creator><creator>Al Juboury, M</creator><creator>Al Husseini, H</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200301</creationdate><title>Paget's disease of the oesophagus associated with mucous gland carcinoma of the lower oesophagus</title><author>Haleem, A ; Kfoury, H ; Al Juboury, M ; Al Husseini, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4334-c96a8d63fe0156d0d613a63594eb2397ddb1f9cb1eed0085093d8ae14f25525e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adenocarcinoma, Mucinous - chemistry</topic><topic>Adenocarcinoma, Mucinous - pathology</topic><topic>Adenocarcinoma, Mucinous - surgery</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Carcinoma - pathology</topic><topic>Carcinoma in Situ - pathology</topic><topic>Carcinoma, Small Cell - pathology</topic><topic>Diagnosis, Differential</topic><topic>Esophageal Neoplasms - chemistry</topic><topic>Esophageal Neoplasms - pathology</topic><topic>Esophageal Neoplasms - surgery</topic><topic>Esophagogastric Junction - pathology</topic><topic>Esophagus</topic><topic>Female</topic><topic>Gastrectomy</topic><topic>Gastric Mucosa - pathology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Lymphoma - pathology</topic><topic>Medical sciences</topic><topic>Melanoma - pathology</topic><topic>mucous gland carcinoma</topic><topic>Neoplasm Proteins - analysis</topic><topic>Neoplasms, Multiple Primary - chemistry</topic><topic>Neoplasms, Multiple Primary - pathology</topic><topic>Neoplasms, Multiple Primary - surgery</topic><topic>oesophageal carcinoma</topic><topic>oesophageal Paget's disease</topic><topic>Paget Disease, Extramammary - chemistry</topic><topic>Paget Disease, Extramammary - pathology</topic><topic>Paget Disease, Extramammary - surgery</topic><topic>Paget's disease</topic><topic>Treatment Outcome</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Haleem, A</creatorcontrib><creatorcontrib>Kfoury, H</creatorcontrib><creatorcontrib>Al Juboury, M</creatorcontrib><creatorcontrib>Al Husseini, H</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Histopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Haleem, A</au><au>Kfoury, H</au><au>Al Juboury, M</au><au>Al Husseini, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Paget's disease of the oesophagus associated with mucous gland carcinoma of the lower oesophagus</atitle><jtitle>Histopathology</jtitle><addtitle>Histopathology</addtitle><date>2003-01</date><risdate>2003</risdate><volume>42</volume><issue>1</issue><spage>61</spage><epage>65</epage><pages>61-65</pages><issn>0309-0167</issn><eissn>1365-2559</eissn><abstract>Aim: To report a rare case of oesophageal Paget's disease and its rarer combination with submucosal gland carcinoma of the lower oesophagus.
Methods and results: A 74‐year‐old Saudi female was admitted with the complaint of dysphagia. Endoscopic examination showed an ulcerated tumour at the gastro–oesophageal junction. Initial biopsy showed an undifferentiated carcinoma with pagetoid spread in the oesophageal stratified squamous epithelium. Oesophago‐gastrectomy specimen showed a lobulated, poorly differentiated mucous gland carcinoma at the gastro–oesophageal junction. The tumour showed focal acinar differentiation and obvious cancerization of the submucosal glands, somewhat similar to the breast lobular carcinoma in situ. One of the isolated and cancerized submucosal glands also showed carcinoma in situ of its duct. Oesophageal surface epithelium showed extensive pagetoid spread, both over and away from the main tumour. The pagetoid tumour cells showed selective positivity for cytokeratin 7, cytokeratin Cam 5.2, BerEP4 and to a lesser extent for CEA.
Conclusions: As far as we know, this is the fifth case report of oesophageal Paget's disease and the first report of its association with the underlying mucous gland carcinoma.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>12493026</pmid><doi>10.1046/j.1365-2559.2003.01514.x</doi><tpages>5</tpages></addata></record> |
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| subjects | Adenocarcinoma, Mucinous - chemistry Adenocarcinoma, Mucinous - pathology Adenocarcinoma, Mucinous - surgery Aged Biological and medical sciences Biomarkers, Tumor - analysis Carcinoma - pathology Carcinoma in Situ - pathology Carcinoma, Small Cell - pathology Diagnosis, Differential Esophageal Neoplasms - chemistry Esophageal Neoplasms - pathology Esophageal Neoplasms - surgery Esophagogastric Junction - pathology Esophagus Female Gastrectomy Gastric Mucosa - pathology Gastroenterology. Liver. Pancreas. Abdomen Humans Immunohistochemistry Lymphoma - pathology Medical sciences Melanoma - pathology mucous gland carcinoma Neoplasm Proteins - analysis Neoplasms, Multiple Primary - chemistry Neoplasms, Multiple Primary - pathology Neoplasms, Multiple Primary - surgery oesophageal carcinoma oesophageal Paget's disease Paget Disease, Extramammary - chemistry Paget Disease, Extramammary - pathology Paget Disease, Extramammary - surgery Paget's disease Treatment Outcome Tumors |
| title | Paget's disease of the oesophagus associated with mucous gland carcinoma of the lower oesophagus |
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