Relevance of p53, bcl-2 and Rb expression on resistance to cisplatin-based chemotherapy in advanced non-small cell lung cancer

Purpose: Tumors with p53 overexpression have been associated with enhanced resistance to cisplatin-based chemotherapy in a few and small studies involving non-small cell lung cancer. The relationships and interactions between p53, Rb and bcl-2 immunostaining, clinical parameters and response to cisp...

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Veröffentlicht in:	Lung cancer (Amsterdam, Netherlands) Netherlands), 2003, Vol.39 (1), p.41-48
Hauptverfasser:	Gregorc, Vanesa, Ludovini, Vienna, Pistola, Lorenza, Darwish, Samir, Floriani, Irene, Bellezza, Guido, Sidoni, Angelo, Cavaliere, Antonio, Scheibel, Massimo, Angelis, Verena De, Bucciarelli, Emilio, Tonato, Maurizio
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents bcl-2 Biological and medical sciences Carcinoma, Non-Small-Cell Lung - diagnosis Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Chemotherapy Cisplatin Cisplatin - pharmacology Cisplatin - therapeutic use Drug Resistance, Neoplasm Female Gene Expression Regulation, Neoplastic Humans Lung cancer Lung Neoplasms - diagnosis Lung Neoplasms - drug therapy Lung Neoplasms - metabolism Lung Neoplasms - pathology Male Medical sciences Middle Aged Neoplasm Staging p53 Pharmacology. Drug treatments Prognosis Proto-Oncogene Proteins c-bcl-2 - metabolism Resistance Retinoblastoma Retinoblastoma Protein - metabolism Smoking Tumor Suppressor Protein p53 - metabolism
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