Differential effects of antipsychotics on expression of antioxidant enzymes and membrane lipid peroxidation in rat brain

Typical and atypical antipsychotics significantly differ in their neurotransmitter receptor affinity profiles, and their efficacy and side effects in schizophrenic patients. Typical antipsychotics have been found to increase the oxidative (i.e. free radical-mediated) cellular injury in rats. Since s...

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Veröffentlicht in:	Journal of psychiatric research 2003, Vol.37 (1), p.43-51
Hauptverfasser:	Parikh, Vinay, Khan, Mohammad M, Mahadik, Sahebarao P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidant enzymes Antipsychotic Agents - pharmacology Atypical antipsychotics Biological and medical sciences Brain Brain - drug effects Brain - enzymology Brain - metabolism Catalase - metabolism Cats Drug toxicity and drugs side effects treatment Enzyme-Linked Immunosorbent Assay - methods Fatty acids Fatty Acids - metabolism Glutathione Peroxidase - metabolism Lipid peroxidation Lipid Peroxidation - drug effects Male Medical sciences Membrane Lipids - metabolism Oxidation-Reduction - drug effects Oxidative stress Oxidoreductases - metabolism Pharmacology. Drug treatments Rats Rats, Wistar Superoxide Dismutase - metabolism Time Factors Toxicity: nervous system and muscle
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