Polycomb group gene silencing proteins are concentrated in the perichromatin compartment of the mammalian nucleus

Human Polycomb group (PcG) proteins are involved in cell-type-dependent epigenetic gene silencing in an evolutionarily conserved manner. We have analysed the subnuclear localisation of these regulatory proteins in two different human cell lines and in rat liver tissue by means of light and electron...

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Veröffentlicht in:	Journal of cell science 2003-01, Vol.116 (Pt 2), p.335-343
Hauptverfasser:	Cmarko, Dusan, Verschure, Pernette J, Otte, Arie P, van Driel, Roel, Fakan, Stanislav
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carrier Proteins Cell Compartmentation - genetics Cell Differentiation - genetics Cell Nucleus - genetics Cell Nucleus - metabolism Cell Nucleus - ultrastructure Chromatin - genetics Chromatin - metabolism Chromatin - ultrastructure DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Eukaryotic Cells - metabolism Eukaryotic Cells - ultrastructure Gene Silencing - physiology Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humans Immunohistochemistry Ligases Microscopy, Electron Nuclear Proteins - genetics Nuclear Proteins - metabolism Polycomb Repressive Complex 1 Polycomb-Group Proteins Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Rats Repressor Proteins - genetics Repressor Proteins - metabolism Transcription, Genetic - genetics Tumor Cells, Cultured Ubiquitin-Protein Ligases
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