Effects of left ventricular dysfunction on the circadian variation of ventricular premature complexes in healed myocardial infarction
Circadian variation in the onset of cardiovascular events including sudden cardiac death, myocardial infarction and ventricular arrhythmias has been described. The effect of left ventricular (LV) dysfunction on the circadian variation of ventricular premature complex (VPC) frequency was evaluated in...
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| Veröffentlicht in: | The American journal of cardiology 1992-04, Vol.69 (12), p.1009-1014 |
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| creator | Gillis, Anne M. Peters, Robert W. Mitchell, L.Brent Duff, Henry J. McDonald, Margot Wyse, D.George |
| description | Circadian variation in the onset of cardiovascular events including sudden cardiac death, myocardial infarction and ventricular arrhythmias has been described. The effect of left ventricular (LV) dysfunction on the circadian variation of ventricular premature complex (VPC) frequency was evaluated in 132 patients with frequent VPCs and reduced LV function after myocardial infarction. Patients were prospectively divided in 2 groups based on LV ejection fraction (EF) (those with LVEF 0.30, a distinct circadian variation of VPCs, and the expected morning increase in VPC frequency were present. In contrast, a distinct circadian variation of VPCs was absent in patients with LVEF ≤0.30. A circadian variation of VPC frequency was also absent in patients with severe symptomatic congestive heart failure (New York Heart Association class III–IV). Treatment with β-adrenoceptor blocking agents was associated with a loss of the circadian variation of VPC frequency. The circadian variation of heart rate was also blunted in the group treated with β-adrenoceptor blocking agents. The proportion of subjects manifesting a positive correlation between heart rate and VPC frequency was tower in subjects with LVEF 0.30 (46%) (p < 0.05). Thus, circadian variation of VPC frequency is absent in patients with severe LV dysfunction. |
| doi_str_mv | 10.1016/0002-9149(92)90855-S |
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In patients with LVEF >0.30, a distinct circadian variation of VPCs, and the expected morning increase in VPC frequency were present. In contrast, a distinct circadian variation of VPCs was absent in patients with LVEF ≤0.30. A circadian variation of VPC frequency was also absent in patients with severe symptomatic congestive heart failure (New York Heart Association class III–IV). Treatment with β-adrenoceptor blocking agents was associated with a loss of the circadian variation of VPC frequency. The circadian variation of heart rate was also blunted in the group treated with β-adrenoceptor blocking agents. The proportion of subjects manifesting a positive correlation between heart rate and VPC frequency was tower in subjects with LVEF <-0.30 (26%) than in those with LVEF >0.30 (46%) (p < 0.05). Thus, circadian variation of VPC frequency is absent in patients with severe LV dysfunction.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/0002-9149(92)90855-S</identifier><identifier>PMID: 1373266</identifier><identifier>CODEN: AJCDAG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adrenergic beta-Antagonists - pharmacology ; Aged ; Biological and medical sciences ; Cardiac Complexes, Premature - etiology ; Cardiac Complexes, Premature - physiopathology ; Cardiology. Vascular system ; Chi-Square Distribution ; Circadian Rhythm - drug effects ; Coronary heart disease ; Electrocardiography, Ambulatory ; Female ; Heart ; Heart Failure - physiopathology ; Heart Rate - drug effects ; Humans ; Incidence ; Male ; Medical sciences ; Middle Aged ; Myocardial Infarction - complications ; Myocardial Infarction - physiopathology ; Prospective Studies ; Ventricular Function, Left - drug effects ; Ventricular Function, Left - physiology</subject><ispartof>The American journal of cardiology, 1992-04, Vol.69 (12), p.1009-1014</ispartof><rights>1992</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-94a254d7d7b0aec90c3472e6725ac3bb837e3e62ab60eca79f67b6d2d736ed303</citedby><cites>FETCH-LOGICAL-c452t-94a254d7d7b0aec90c3472e6725ac3bb837e3e62ab60eca79f67b6d2d736ed303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/000291499290855S$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5270900$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1373266$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gillis, Anne M.</creatorcontrib><creatorcontrib>Peters, Robert W.</creatorcontrib><creatorcontrib>Mitchell, L.Brent</creatorcontrib><creatorcontrib>Duff, Henry J.</creatorcontrib><creatorcontrib>McDonald, Margot</creatorcontrib><creatorcontrib>Wyse, D.George</creatorcontrib><title>Effects of left ventricular dysfunction on the circadian variation of ventricular premature complexes in healed myocardial infarction</title><title>The American journal of cardiology</title><addtitle>Am J Cardiol</addtitle><description>Circadian variation in the onset of cardiovascular events including sudden cardiac death, myocardial infarction and ventricular arrhythmias has been described. The effect of left ventricular (LV) dysfunction on the circadian variation of ventricular premature complex (VPC) frequency was evaluated in 132 patients with frequent VPCs and reduced LV function after myocardial infarction. Patients were prospectively divided in 2 groups based on LV ejection fraction (EF) (those with LVEF <0.30, and those with LVEF between 0.30 and 0.45). Median hourly VPC frequencies and heart rates were compared between the 2 groups. Subgroup analyses based on treatment with β-adrenoceptor blocking agents and on New York Heart Association functional class were also performed.
In patients with LVEF >0.30, a distinct circadian variation of VPCs, and the expected morning increase in VPC frequency were present. In contrast, a distinct circadian variation of VPCs was absent in patients with LVEF ≤0.30. A circadian variation of VPC frequency was also absent in patients with severe symptomatic congestive heart failure (New York Heart Association class III–IV). Treatment with β-adrenoceptor blocking agents was associated with a loss of the circadian variation of VPC frequency. The circadian variation of heart rate was also blunted in the group treated with β-adrenoceptor blocking agents. The proportion of subjects manifesting a positive correlation between heart rate and VPC frequency was tower in subjects with LVEF <-0.30 (26%) than in those with LVEF >0.30 (46%) (p < 0.05). Thus, circadian variation of VPC frequency is absent in patients with severe LV dysfunction.</description><subject>Adrenergic beta-Antagonists - pharmacology</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cardiac Complexes, Premature - etiology</subject><subject>Cardiac Complexes, Premature - physiopathology</subject><subject>Cardiology. Vascular system</subject><subject>Chi-Square Distribution</subject><subject>Circadian Rhythm - drug effects</subject><subject>Coronary heart disease</subject><subject>Electrocardiography, Ambulatory</subject><subject>Female</subject><subject>Heart</subject><subject>Heart Failure - physiopathology</subject><subject>Heart Rate - drug effects</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - complications</subject><subject>Myocardial Infarction - physiopathology</subject><subject>Prospective Studies</subject><subject>Ventricular Function, Left - drug effects</subject><subject>Ventricular Function, Left - physiology</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc2KFDEUhYMoY8_oGyhkIaKL0vxUJZXNgAwzKgy4GF2HW8kNE6mfNqlq7AfwvU1ZzYgbIXBJzncOlxNCXnD2jjOu3jPGRGV4bd4Y8dawtmmqu0dkx1ttKm64fEx2D8hTcp7z93LlvFFn5IxLLYVSO_LrOgR0c6ZToD2GmR5wnFN0Sw-J-mMOy-jmOI20nPkeqYvJgY8w0gOkCJsU_nHtEw4wL6nA07Dv8SdmGkd6j9Cjp8NxcpBKQl8eA6Q_6c_IkwB9xueneUG-3Vx_vfpU3X75-Pnqw23l6kbMlalBNLXXXncM0BnmZK0FKi0acLLrWqlRohLQKYYOtAlKd8oLr6VCL5m8IK-33H2afiyYZzvE7LDvYcRpyVaLtq1r1Raw3kCXppwTBrtPcYB0tJzZtX27VmvXaq0pc23f3hXby1P-0g3o_5q2uov-6qRDdtCHBKOL-QFrhGaGrWtebhiWLg4Rk80u4ujQx1Q-y_op_n-P3_PipG4</recordid><startdate>19920415</startdate><enddate>19920415</enddate><creator>Gillis, Anne M.</creator><creator>Peters, Robert W.</creator><creator>Mitchell, L.Brent</creator><creator>Duff, Henry J.</creator><creator>McDonald, Margot</creator><creator>Wyse, D.George</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19920415</creationdate><title>Effects of left ventricular dysfunction on the circadian variation of ventricular premature complexes in healed myocardial infarction</title><author>Gillis, Anne M. ; Peters, Robert W. ; Mitchell, L.Brent ; Duff, Henry J. ; McDonald, Margot ; Wyse, D.George</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-94a254d7d7b0aec90c3472e6725ac3bb837e3e62ab60eca79f67b6d2d736ed303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adrenergic beta-Antagonists - pharmacology</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Cardiac Complexes, Premature - etiology</topic><topic>Cardiac Complexes, Premature - physiopathology</topic><topic>Cardiology. Vascular system</topic><topic>Chi-Square Distribution</topic><topic>Circadian Rhythm - drug effects</topic><topic>Coronary heart disease</topic><topic>Electrocardiography, Ambulatory</topic><topic>Female</topic><topic>Heart</topic><topic>Heart Failure - physiopathology</topic><topic>Heart Rate - drug effects</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myocardial Infarction - complications</topic><topic>Myocardial Infarction - physiopathology</topic><topic>Prospective Studies</topic><topic>Ventricular Function, Left - drug effects</topic><topic>Ventricular Function, Left - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gillis, Anne M.</creatorcontrib><creatorcontrib>Peters, Robert W.</creatorcontrib><creatorcontrib>Mitchell, L.Brent</creatorcontrib><creatorcontrib>Duff, Henry J.</creatorcontrib><creatorcontrib>McDonald, Margot</creatorcontrib><creatorcontrib>Wyse, D.George</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gillis, Anne M.</au><au>Peters, Robert W.</au><au>Mitchell, L.Brent</au><au>Duff, Henry J.</au><au>McDonald, Margot</au><au>Wyse, D.George</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of left ventricular dysfunction on the circadian variation of ventricular premature complexes in healed myocardial infarction</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>1992-04-15</date><risdate>1992</risdate><volume>69</volume><issue>12</issue><spage>1009</spage><epage>1014</epage><pages>1009-1014</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><coden>AJCDAG</coden><abstract>Circadian variation in the onset of cardiovascular events including sudden cardiac death, myocardial infarction and ventricular arrhythmias has been described. The effect of left ventricular (LV) dysfunction on the circadian variation of ventricular premature complex (VPC) frequency was evaluated in 132 patients with frequent VPCs and reduced LV function after myocardial infarction. Patients were prospectively divided in 2 groups based on LV ejection fraction (EF) (those with LVEF <0.30, and those with LVEF between 0.30 and 0.45). Median hourly VPC frequencies and heart rates were compared between the 2 groups. Subgroup analyses based on treatment with β-adrenoceptor blocking agents and on New York Heart Association functional class were also performed.
In patients with LVEF >0.30, a distinct circadian variation of VPCs, and the expected morning increase in VPC frequency were present. In contrast, a distinct circadian variation of VPCs was absent in patients with LVEF ≤0.30. A circadian variation of VPC frequency was also absent in patients with severe symptomatic congestive heart failure (New York Heart Association class III–IV). Treatment with β-adrenoceptor blocking agents was associated with a loss of the circadian variation of VPC frequency. The circadian variation of heart rate was also blunted in the group treated with β-adrenoceptor blocking agents. The proportion of subjects manifesting a positive correlation between heart rate and VPC frequency was tower in subjects with LVEF <-0.30 (26%) than in those with LVEF >0.30 (46%) (p < 0.05). Thus, circadian variation of VPC frequency is absent in patients with severe LV dysfunction.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>1373266</pmid><doi>10.1016/0002-9149(92)90855-S</doi><tpages>6</tpages></addata></record> |
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| subjects | Adrenergic beta-Antagonists - pharmacology Aged Biological and medical sciences Cardiac Complexes, Premature - etiology Cardiac Complexes, Premature - physiopathology Cardiology. Vascular system Chi-Square Distribution Circadian Rhythm - drug effects Coronary heart disease Electrocardiography, Ambulatory Female Heart Heart Failure - physiopathology Heart Rate - drug effects Humans Incidence Male Medical sciences Middle Aged Myocardial Infarction - complications Myocardial Infarction - physiopathology Prospective Studies Ventricular Function, Left - drug effects Ventricular Function, Left - physiology |
| title | Effects of left ventricular dysfunction on the circadian variation of ventricular premature complexes in healed myocardial infarction |
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