Increased expression of p21(waf) cyclin-dependent kinase inhibitor in asthmatic bronchial epithelium

Because the asthmatic bronchial epithelium is characterized by widespread damage, we postulated that this is associated with expression of cell cycle inhibitors that control proliferation. Using bronchial biopsies, the epithelium was the major site of expression of the cyclin-dependent kinase inhibi...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2003-01, Vol.28 (1), p.61-68
Hauptverfasser:	Puddicombe, Sarah M, Torres-Lozano, Carlos, Richter, Audrey, Bucchieri, Fabio, Lordan, James L, Howarth, Peter H, Vrugt, Bart, Albers, Rene, Djukanovic, Ratko, Holgate, Stephen T, Wilson, Susan J, Davies, Donna E
Format:	Artikel
Sprache:	eng
Schlagworte:	Asthma - metabolism Blotting, Western Bronchi - cytology Bronchi - drug effects Bronchi - metabolism Cells, Cultured Cyclin-Dependent Kinase Inhibitor p21 Cyclins - genetics Cyclins - metabolism Dexamethasone - pharmacology DNA Replication - drug effects Epidermal Growth Factor - pharmacology Epithelial Cells - drug effects Epithelial Cells - metabolism Flow Cytometry Humans Hydrogen Peroxide - pharmacology Immunohistochemistry Proliferating Cell Nuclear Antigen - metabolism RNA, Messenger - genetics Transforming Growth Factor beta - pharmacology
Online-Zugang:	Volltext
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