Jak2 and proteasome activities control the availability of cell surface growth hormone receptors during ligand exposure

Several mechanisms participate in the down-regulation of growth hormone receptor (GHR) signalling under ligand exposure. In CHO cells expressing GHR, we show that ligand stimulation induces degradation of the total cell GHR content. Experiments with 125I-hGH indicate that ligand-bound internalized r...

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Veröffentlicht in:	Cellular signalling 2003, Vol.15 (1), p.47-55
Hauptverfasser:	Moulin, Stéphanie, Bouzinba-Segard, Haniaa, Kelly, Paul A, Finidori, Joëlle
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Compartmentation Cell Membrane - metabolism CHO Cells Cricetinae Cysteine Endopeptidases - metabolism Cysteine Endopeptidases - physiology Cysteine Proteinase Inhibitors - pharmacology Down-Regulation Growth hormone Growth Hormone - metabolism Internalization Jak2 Janus Kinase 2 Kinetics Ligands Models, Biological Multienzyme Complexes - antagonists & inhibitors Multienzyme Complexes - metabolism Multienzyme Complexes - physiology Proteasome Proteasome Endopeptidase Complex Protein Transport Protein-Tyrosine Kinases - metabolism Protein-Tyrosine Kinases - physiology Proto-Oncogene Proteins Receptor degradation Receptors, Somatotropin - metabolism
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