Exonic polymorphism vs intronic simple repeat hypervariability in MHC-DRB genes

Gene products encoded by the major histocompatibility complex often exhibit a high degree of polymorphism. In humans the HLA-DR polymorphism is due to more than 50 alleles with varying exon 2 sequences. Each group of DRB alleles contains a certain form of the basic simple repeat motif (gt)n(ga)m in...

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Veröffentlicht in:	Immunogenetics (New York) 1992-03, Vol.35 (5), p.332-340
Hauptverfasser:	AMMER, H, SCHWEIGER, F.-W, KAMMERBAUER, C, GOMOLKA, M, ARRIENS, A, LAZARY, S, EPPLEN, J. T
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Amino Acid Sequence Animals Base Sequence Biological and medical sciences Biological evolution Cattle Exons - genetics Fundamental and applied biological sciences. Psychology Genetic Variation Genetics of eukaryotes. Biological and molecular evolution Histocompatibility Antigens Class I - genetics Introns - genetics Molecular Sequence Data Multigene Family Nucleic Acid Hybridization Oligonucleotide Probes Phylogeny Polymerase Chain Reaction Polymorphism, Genetic Sequence Homology, Nucleic Acid
Online-Zugang:	Volltext
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