Histological lesions in vascular tissues of bovine herpes virus type 4-infected rabbits
The gamma-herpes virus bovine herpes virus type 4 (BoHV-4) is distributed worldwide in cattle populations with unknown pathogenicity. Bovine endothelial cells were recently shown to be susceptible to BoHV-4 infection in vitro and this virus accelerated the cholesterol-induced atherosclerotic process...
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| Veröffentlicht in: | Veterinary microbiology 2003-01, Vol.91 (1), p.1-10 |
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| creator | Egyed, László Baska, Ferenc |
| description | The gamma-herpes virus bovine herpes virus type 4 (BoHV-4) is distributed worldwide in cattle populations with unknown pathogenicity. Bovine endothelial cells were recently shown to be susceptible to BoHV-4 infection in vitro and this virus accelerated the cholesterol-induced atherosclerotic process in rabbits. In this study, the in vivo effect of BoHV-4 on cardiovascular tissue was investigated by intravenous infection of rabbits fed a cholesterol free diet. Inflammatory lesions of vascular tissue in aortic and valvular endothelial cells, and smooth muscle cells were detected by H&E staining, PCR, IF, EM immunohistochemistry, while virus isolation was used to detect virus particles. Acute and chronic vasculitis, signs of chronic endocarditis, with mononuclear cell accumulation and a fresh thrombus was found. Herpes viruses have already been thought to initiate cardio-vascular disorders, now this paper shows that a bovine gamma-herpes virus could also be a causative agent of vascular lesions in mammals fed a normal diet. BoHV-4-infection of rabbits could serve as a useful animal model for research into virus-induced human cardio-vascular diseases. |
| doi_str_mv | 10.1016/S0378-1135(02)00261-4 |
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Bovine endothelial cells were recently shown to be susceptible to BoHV-4 infection in vitro and this virus accelerated the cholesterol-induced atherosclerotic process in rabbits. In this study, the in vivo effect of BoHV-4 on cardiovascular tissue was investigated by intravenous infection of rabbits fed a cholesterol free diet. Inflammatory lesions of vascular tissue in aortic and valvular endothelial cells, and smooth muscle cells were detected by H&E staining, PCR, IF, EM immunohistochemistry, while virus isolation was used to detect virus particles. Acute and chronic vasculitis, signs of chronic endocarditis, with mononuclear cell accumulation and a fresh thrombus was found. Herpes viruses have already been thought to initiate cardio-vascular disorders, now this paper shows that a bovine gamma-herpes virus could also be a causative agent of vascular lesions in mammals fed a normal diet. BoHV-4-infection of rabbits could serve as a useful animal model for research into virus-induced human cardio-vascular diseases.</description><identifier>ISSN: 0378-1135</identifier><identifier>EISSN: 1873-2542</identifier><identifier>DOI: 10.1016/S0378-1135(02)00261-4</identifier><identifier>PMID: 12441227</identifier><identifier>CODEN: VMICDQ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animal viral diseases ; Animals ; Antibodies, Viral - metabolism ; Aorta, Thoracic - pathology ; Aorta, Thoracic - virology ; Biological and medical sciences ; Bovine herpesvirus type 4 ; Cardio-vascular system ; Dexamethasone - metabolism ; DNA, Viral - chemistry ; DNA, Viral - genetics ; Fluorescent Antibody Technique - veterinary ; Heart - virology ; Herpesviridae Infections - pathology ; Herpesviridae Infections - veterinary ; Herpesviridae Infections - virology ; Herpesvirus 4, Bovine - genetics ; Herpesvirus 4, Bovine - growth & development ; Histology ; Immunosuppressive Agents - metabolism ; Infectious diseases ; Medical sciences ; Muscle, Smooth, Vascular - pathology ; Muscle, Smooth, Vascular - virology ; Myocardium - pathology ; Polymerase Chain Reaction - veterinary ; Rabbit ; Rabbits - virology ; Vasculitis - veterinary ; Vasculitis - virology ; Viral diseases</subject><ispartof>Veterinary microbiology, 2003-01, Vol.91 (1), p.1-10</ispartof><rights>2002 Elsevier Science B.V.</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-b2f9fea4487ad325c141989519be3b99742e90391d0eb4e044afc320a7a0fbad3</citedby><cites>FETCH-LOGICAL-c422t-b2f9fea4487ad325c141989519be3b99742e90391d0eb4e044afc320a7a0fbad3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0378-1135(02)00261-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14394455$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12441227$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Egyed, László</creatorcontrib><creatorcontrib>Baska, Ferenc</creatorcontrib><title>Histological lesions in vascular tissues of bovine herpes virus type 4-infected rabbits</title><title>Veterinary microbiology</title><addtitle>Vet Microbiol</addtitle><description>The gamma-herpes virus bovine herpes virus type 4 (BoHV-4) is distributed worldwide in cattle populations with unknown pathogenicity. Bovine endothelial cells were recently shown to be susceptible to BoHV-4 infection in vitro and this virus accelerated the cholesterol-induced atherosclerotic process in rabbits. In this study, the in vivo effect of BoHV-4 on cardiovascular tissue was investigated by intravenous infection of rabbits fed a cholesterol free diet. Inflammatory lesions of vascular tissue in aortic and valvular endothelial cells, and smooth muscle cells were detected by H&E staining, PCR, IF, EM immunohistochemistry, while virus isolation was used to detect virus particles. Acute and chronic vasculitis, signs of chronic endocarditis, with mononuclear cell accumulation and a fresh thrombus was found. Herpes viruses have already been thought to initiate cardio-vascular disorders, now this paper shows that a bovine gamma-herpes virus could also be a causative agent of vascular lesions in mammals fed a normal diet. BoHV-4-infection of rabbits could serve as a useful animal model for research into virus-induced human cardio-vascular diseases.</description><subject>Animal viral diseases</subject><subject>Animals</subject><subject>Antibodies, Viral - metabolism</subject><subject>Aorta, Thoracic - pathology</subject><subject>Aorta, Thoracic - virology</subject><subject>Biological and medical sciences</subject><subject>Bovine herpesvirus type 4</subject><subject>Cardio-vascular system</subject><subject>Dexamethasone - metabolism</subject><subject>DNA, Viral - chemistry</subject><subject>DNA, Viral - genetics</subject><subject>Fluorescent Antibody Technique - veterinary</subject><subject>Heart - virology</subject><subject>Herpesviridae Infections - pathology</subject><subject>Herpesviridae Infections - veterinary</subject><subject>Herpesviridae Infections - virology</subject><subject>Herpesvirus 4, Bovine - genetics</subject><subject>Herpesvirus 4, Bovine - growth & development</subject><subject>Histology</subject><subject>Immunosuppressive Agents - metabolism</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Muscle, Smooth, Vascular - pathology</subject><subject>Muscle, Smooth, Vascular - virology</subject><subject>Myocardium - pathology</subject><subject>Polymerase Chain Reaction - veterinary</subject><subject>Rabbit</subject><subject>Rabbits - virology</subject><subject>Vasculitis - veterinary</subject><subject>Vasculitis - virology</subject><subject>Viral diseases</subject><issn>0378-1135</issn><issn>1873-2542</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhi1ERZfCTwD5QgWHgD8mcXxCqAJaqRIHQBwt25mAUTZePMlK_fd1uyt67Gmk0fPOvHoYeyXFeylk9-G70KZvpNTtW6HeCaE62cATtpG90Y1qQT1lm__IKXtO9FcIAbYTz9ipVABSKbNhvy4TLXnKv1P0E5-QUp6Jp5nvPcV18oUviWhF4nnkIe_TjPwPll1d7FNZiS83O-TQpHnEuODAiw8hLfSCnYx-Inx5nGfs55fPPy4um-tvX68uPl03EZRamqBGO6IH6I0ftGqjBGl720obUAdrDSi0Qls5CAyAAsCPUSvhjRdjqJEzdn64uyv5X625uG2iiNPkZ8wrOaN6Y7Uyj4Ky76C3XV_B9gDGkokKjm5X0taXGyeFu1Pv7tW7O69OKHev3kHNvT4-WMMWh4fU0XUF3hyBqtZPY_FzTPTAgbYAbVu5jwcOq7d9wuIoJpwjDqlUx27I6ZEqt-ZZoF0</recordid><startdate>20030102</startdate><enddate>20030102</enddate><creator>Egyed, László</creator><creator>Baska, Ferenc</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20030102</creationdate><title>Histological lesions in vascular tissues of bovine herpes virus type 4-infected rabbits</title><author>Egyed, László ; Baska, Ferenc</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-b2f9fea4487ad325c141989519be3b99742e90391d0eb4e044afc320a7a0fbad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animal viral diseases</topic><topic>Animals</topic><topic>Antibodies, Viral - metabolism</topic><topic>Aorta, Thoracic - pathology</topic><topic>Aorta, Thoracic - virology</topic><topic>Biological and medical sciences</topic><topic>Bovine herpesvirus type 4</topic><topic>Cardio-vascular system</topic><topic>Dexamethasone - metabolism</topic><topic>DNA, Viral - chemistry</topic><topic>DNA, Viral - genetics</topic><topic>Fluorescent Antibody Technique - veterinary</topic><topic>Heart - virology</topic><topic>Herpesviridae Infections - pathology</topic><topic>Herpesviridae Infections - veterinary</topic><topic>Herpesviridae Infections - virology</topic><topic>Herpesvirus 4, Bovine - genetics</topic><topic>Herpesvirus 4, Bovine - growth & development</topic><topic>Histology</topic><topic>Immunosuppressive Agents - metabolism</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Muscle, Smooth, Vascular - pathology</topic><topic>Muscle, Smooth, Vascular - virology</topic><topic>Myocardium - pathology</topic><topic>Polymerase Chain Reaction - veterinary</topic><topic>Rabbit</topic><topic>Rabbits - virology</topic><topic>Vasculitis - veterinary</topic><topic>Vasculitis - virology</topic><topic>Viral diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Egyed, László</creatorcontrib><creatorcontrib>Baska, Ferenc</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Egyed, László</au><au>Baska, Ferenc</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histological lesions in vascular tissues of bovine herpes virus type 4-infected rabbits</atitle><jtitle>Veterinary microbiology</jtitle><addtitle>Vet Microbiol</addtitle><date>2003-01-02</date><risdate>2003</risdate><volume>91</volume><issue>1</issue><spage>1</spage><epage>10</epage><pages>1-10</pages><issn>0378-1135</issn><eissn>1873-2542</eissn><coden>VMICDQ</coden><abstract>The gamma-herpes virus bovine herpes virus type 4 (BoHV-4) is distributed worldwide in cattle populations with unknown pathogenicity. Bovine endothelial cells were recently shown to be susceptible to BoHV-4 infection in vitro and this virus accelerated the cholesterol-induced atherosclerotic process in rabbits. In this study, the in vivo effect of BoHV-4 on cardiovascular tissue was investigated by intravenous infection of rabbits fed a cholesterol free diet. Inflammatory lesions of vascular tissue in aortic and valvular endothelial cells, and smooth muscle cells were detected by H&E staining, PCR, IF, EM immunohistochemistry, while virus isolation was used to detect virus particles. Acute and chronic vasculitis, signs of chronic endocarditis, with mononuclear cell accumulation and a fresh thrombus was found. Herpes viruses have already been thought to initiate cardio-vascular disorders, now this paper shows that a bovine gamma-herpes virus could also be a causative agent of vascular lesions in mammals fed a normal diet. BoHV-4-infection of rabbits could serve as a useful animal model for research into virus-induced human cardio-vascular diseases.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>12441227</pmid><doi>10.1016/S0378-1135(02)00261-4</doi><tpages>10</tpages></addata></record> |
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| subjects | Animal viral diseases Animals Antibodies, Viral - metabolism Aorta, Thoracic - pathology Aorta, Thoracic - virology Biological and medical sciences Bovine herpesvirus type 4 Cardio-vascular system Dexamethasone - metabolism DNA, Viral - chemistry DNA, Viral - genetics Fluorescent Antibody Technique - veterinary Heart - virology Herpesviridae Infections - pathology Herpesviridae Infections - veterinary Herpesviridae Infections - virology Herpesvirus 4, Bovine - genetics Herpesvirus 4, Bovine - growth & development Histology Immunosuppressive Agents - metabolism Infectious diseases Medical sciences Muscle, Smooth, Vascular - pathology Muscle, Smooth, Vascular - virology Myocardium - pathology Polymerase Chain Reaction - veterinary Rabbit Rabbits - virology Vasculitis - veterinary Vasculitis - virology Viral diseases |
| title | Histological lesions in vascular tissues of bovine herpes virus type 4-infected rabbits |
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