Propionibacterium acnes-enhanced lens-induced granulomatous uveitis in the rat
Propionibacterium acnes (Corynebacterium parvum) is being implicated more frequently as a cause of intraocular inflammation following cataract surgery. In addition to its role as an infectious agent, P. acnes also may possess adjuvant-like or adjuvant-enhancing properties. The presence of this organ...
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| Veröffentlicht in: | Investigative ophthalmology & visual science 1992-04, Vol.33 (5), p.1766-1770 |
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| container_title | Investigative ophthalmology & visual science |
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| creator | Semel, J Bowe, B Guo, A Lee, L Rife, L Polikoff, D Summanen, P Pararajasegaram, G Finegold, SM Rao, N |
| description | Propionibacterium acnes (Corynebacterium parvum) is being implicated more frequently as a cause of intraocular inflammation following cataract surgery. In addition to its role as an infectious agent, P. acnes also may possess adjuvant-like or adjuvant-enhancing properties. The presence of this organism in an eye with residual lens material after extracapsular cataract surgery could augment inflammation resulting from a phacoantigenic (phacoanaphylactic) response. We have modified an established rat model of lens-induced granulomatous uveitis (LIGU) to examine the adjuvant properties of P. acnes. Our results suggest that P. acnes effectively potentiates LIGU. |
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In addition to its role as an infectious agent, P. acnes also may possess adjuvant-like or adjuvant-enhancing properties. The presence of this organism in an eye with residual lens material after extracapsular cataract surgery could augment inflammation resulting from a phacoantigenic (phacoanaphylactic) response. We have modified an established rat model of lens-induced granulomatous uveitis (LIGU) to examine the adjuvant properties of P. acnes. Our results suggest that P. acnes effectively potentiates LIGU.</description><identifier>ISSN: 0146-0404</identifier><identifier>EISSN: 1552-5783</identifier><identifier>PMID: 1559776</identifier><identifier>CODEN: IOVSDA</identifier><language>eng</language><publisher>Rockville, MD: ARVO</publisher><subject>Adjuvants, Immunologic ; Animals ; Biological and medical sciences ; Crystallins - immunology ; Disease Models, Animal ; Freund's Adjuvant ; Granuloma - immunology ; Granuloma - pathology ; Lens Capsule, Crystalline - surgery ; Lens Diseases - immunology ; Lens Diseases - pathology ; Male ; Medical sciences ; Ophthalmology ; Propionibacterium acnes - immunology ; Rats ; Uvea diseases ; Uveitis - immunology ; Uveitis - pathology</subject><ispartof>Investigative ophthalmology & visual science, 1992-04, Vol.33 (5), p.1766-1770</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5394900$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1559776$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Semel, J</creatorcontrib><creatorcontrib>Bowe, B</creatorcontrib><creatorcontrib>Guo, A</creatorcontrib><creatorcontrib>Lee, L</creatorcontrib><creatorcontrib>Rife, L</creatorcontrib><creatorcontrib>Polikoff, D</creatorcontrib><creatorcontrib>Summanen, P</creatorcontrib><creatorcontrib>Pararajasegaram, G</creatorcontrib><creatorcontrib>Finegold, SM</creatorcontrib><creatorcontrib>Rao, N</creatorcontrib><title>Propionibacterium acnes-enhanced lens-induced granulomatous uveitis in the rat</title><title>Investigative ophthalmology & visual science</title><addtitle>Invest Ophthalmol Vis Sci</addtitle><description>Propionibacterium acnes (Corynebacterium parvum) is being implicated more frequently as a cause of intraocular inflammation following cataract surgery. In addition to its role as an infectious agent, P. acnes also may possess adjuvant-like or adjuvant-enhancing properties. The presence of this organism in an eye with residual lens material after extracapsular cataract surgery could augment inflammation resulting from a phacoantigenic (phacoanaphylactic) response. We have modified an established rat model of lens-induced granulomatous uveitis (LIGU) to examine the adjuvant properties of P. acnes. Our results suggest that P. acnes effectively potentiates LIGU.</description><subject>Adjuvants, Immunologic</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Crystallins - immunology</subject><subject>Disease Models, Animal</subject><subject>Freund's Adjuvant</subject><subject>Granuloma - immunology</subject><subject>Granuloma - pathology</subject><subject>Lens Capsule, Crystalline - surgery</subject><subject>Lens Diseases - immunology</subject><subject>Lens Diseases - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Ophthalmology</subject><subject>Propionibacterium acnes - immunology</subject><subject>Rats</subject><subject>Uvea diseases</subject><subject>Uveitis - immunology</subject><subject>Uveitis - pathology</subject><issn>0146-0404</issn><issn>1552-5783</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkFtLxDAQhYMo67r6E4Q-iG-F3NM8yuINFvVBn0OapNtImq5Ja_HfW7EoDAzD-ThzZo7AGjGGSyYqcgzWEFFeQgrpKTjL-R1CjBCGK7CaISkEX4Onl9QffB99rc3gkh-7Qpvoculiq6Nxtggu5tJHO_4M-6TjGPpOD_2Yi_HT-cHnwsdiaF2R9HAOThodsrtY-ga83d2-bh_K3fP94_ZmV7aY86FspIQCUyutQA02kjJoqZbSOsZQbYmsOGLSUIwl1wiLytW10ZAI6SjEhpINuP71PaT-Y3R5UJ3PxoWgo5uTKYErUc01g5cLONads-qQfKfTl1oeMOtXi66z0aGZ7zM-_2GMSCoh_N_X-n07-eRU7nQIsylS0zQRophCgnPyDbPVchw</recordid><startdate>19920401</startdate><enddate>19920401</enddate><creator>Semel, J</creator><creator>Bowe, B</creator><creator>Guo, A</creator><creator>Lee, L</creator><creator>Rife, L</creator><creator>Polikoff, D</creator><creator>Summanen, P</creator><creator>Pararajasegaram, G</creator><creator>Finegold, SM</creator><creator>Rao, N</creator><general>ARVO</general><general>Association for Research in Vision and Ophtalmology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19920401</creationdate><title>Propionibacterium acnes-enhanced lens-induced granulomatous uveitis in the rat</title><author>Semel, J ; Bowe, B ; Guo, A ; Lee, L ; Rife, L ; Polikoff, D ; Summanen, P ; Pararajasegaram, G ; Finegold, SM ; Rao, N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h266t-f990724d9d71f2c9450d4a99de551bd3986159c42296a1278ebbca0379e402c43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adjuvants, Immunologic</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Crystallins - immunology</topic><topic>Disease Models, Animal</topic><topic>Freund's Adjuvant</topic><topic>Granuloma - immunology</topic><topic>Granuloma - pathology</topic><topic>Lens Capsule, Crystalline - surgery</topic><topic>Lens Diseases - immunology</topic><topic>Lens Diseases - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Ophthalmology</topic><topic>Propionibacterium acnes - immunology</topic><topic>Rats</topic><topic>Uvea diseases</topic><topic>Uveitis - immunology</topic><topic>Uveitis - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Semel, J</creatorcontrib><creatorcontrib>Bowe, B</creatorcontrib><creatorcontrib>Guo, A</creatorcontrib><creatorcontrib>Lee, L</creatorcontrib><creatorcontrib>Rife, L</creatorcontrib><creatorcontrib>Polikoff, D</creatorcontrib><creatorcontrib>Summanen, P</creatorcontrib><creatorcontrib>Pararajasegaram, G</creatorcontrib><creatorcontrib>Finegold, SM</creatorcontrib><creatorcontrib>Rao, N</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Investigative ophthalmology & visual science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Semel, J</au><au>Bowe, B</au><au>Guo, A</au><au>Lee, L</au><au>Rife, L</au><au>Polikoff, D</au><au>Summanen, P</au><au>Pararajasegaram, G</au><au>Finegold, SM</au><au>Rao, N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Propionibacterium acnes-enhanced lens-induced granulomatous uveitis in the rat</atitle><jtitle>Investigative ophthalmology & visual science</jtitle><addtitle>Invest Ophthalmol Vis Sci</addtitle><date>1992-04-01</date><risdate>1992</risdate><volume>33</volume><issue>5</issue><spage>1766</spage><epage>1770</epage><pages>1766-1770</pages><issn>0146-0404</issn><eissn>1552-5783</eissn><coden>IOVSDA</coden><abstract>Propionibacterium acnes (Corynebacterium parvum) is being implicated more frequently as a cause of intraocular inflammation following cataract surgery. In addition to its role as an infectious agent, P. acnes also may possess adjuvant-like or adjuvant-enhancing properties. The presence of this organism in an eye with residual lens material after extracapsular cataract surgery could augment inflammation resulting from a phacoantigenic (phacoanaphylactic) response. We have modified an established rat model of lens-induced granulomatous uveitis (LIGU) to examine the adjuvant properties of P. acnes. Our results suggest that P. acnes effectively potentiates LIGU.</abstract><cop>Rockville, MD</cop><pub>ARVO</pub><pmid>1559776</pmid><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0146-0404 |
| ispartof | Investigative ophthalmology & visual science, 1992-04, Vol.33 (5), p.1766-1770 |
| issn | 0146-0404 1552-5783 |
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| subjects | Adjuvants, Immunologic Animals Biological and medical sciences Crystallins - immunology Disease Models, Animal Freund's Adjuvant Granuloma - immunology Granuloma - pathology Lens Capsule, Crystalline - surgery Lens Diseases - immunology Lens Diseases - pathology Male Medical sciences Ophthalmology Propionibacterium acnes - immunology Rats Uvea diseases Uveitis - immunology Uveitis - pathology |
| title | Propionibacterium acnes-enhanced lens-induced granulomatous uveitis in the rat |
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