Protease composition of exocytosed human skin mast cell protease- proteoglycan complexes. Tryptase resides in a complex distinct from chymase and carboxypeptidase

We characterized the release and the protease composition of high m.w. complexes released from dispersed human skin mast cells, under conditions that did not disrupt the binding of proteases to proteoglycan. The net percent release ratio of tryptase to histamine, after anti-IgE and calcium ionophore...

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Veröffentlicht in:	The Journal of immunology (1950) 1992-04, Vol.148 (8), p.2475-2482
Hauptverfasser:	Goldstein, SM, Leong, J, Schwartz, LB, Cooke, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Carboxypeptidases - analysis Chromatography, Affinity Chromatography, Gel Chymases Exocytosis Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunobiology Mast Cells - enzymology Molecular Weight Myeloid cells: ontogeny, maturation, markers, receptors Peptide Hydrolases - analysis Polynuclears Proteoglycans - analysis Serine Endopeptidases - analysis
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