Trypanosoma cruzi: requirements for induction and maintenance of protective immunity conferred by immunization

Immunization with CL-14-trypomastigotes generates efficient humoral and cellular responses against infective challenge. Herein, we investigated the relevance of these mechanisms in vivo. Immunization with live CL-14-trypomastigotes protected only part of β2m −/− mice but efficiently protected perfor...

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Veröffentlicht in:	Experimental parasitology 2002-10, Vol.102 (2), p.89-98
Hauptverfasser:	Paiva, Cláudia N, Pyrrho, Alexandre S, Ribeiro, Liane J, Gonçalves, Renata, Costa, Deise A, Araujo-Jorge, Tania C, Soares, Milena B.P, Gattass, Cerli R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Protozoan - blood beta 2-Microglobulin - genetics Biological and medical sciences Bone Marrow Transplantation - immunology CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology Chagas Disease - immunology Chagas Disease - prevention & control Experimental protozoal diseases and models Female Immunity, Cellular Immunization Immunization, Passive Immunoglobulin G - blood Infectious diseases Lymphoid Tissue - immunology Lymphoid Tissue - radiation effects Male Medical sciences Membrane Glycoproteins - genetics Mice Mice, Inbred BALB C Mice, Knockout Parasitemia - immunology Parasitemia - prevention & control Parasitic diseases Perforin Pore Forming Cytotoxic Proteins Protozoal diseases Trypanosoma cruzi - immunology Whole-Body Irradiation
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