Evaluation of the penetration strength, bactericidal efficacy and spectrum of action of several antimicrobial creams against isolated microorganisms in a burn centre
The antibacterial activity of eight antiseptic creams: 1 per cent silver sulphadiazine; 0.2 per cent nitrofurazone; 0.1, 0.5 and 1 per cent chlorhexidine; 2.2 per cent cerium nitrate; 10 per cent povidone iodine; and 1 per cent silver sulphadiazine with 2.2 per cent cerium nitrate were evaluated in...
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| Veröffentlicht in: | Burns 1992-02, Vol.18 (1), p.39-44 |
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| creator | Herruzo-Cabrera, R. Garcia-Torres, V. Rey-Calero, J. Vizcaino-Alcaide, M.J. |
| description | The antibacterial activity of eight antiseptic creams: 1 per cent silver sulphadiazine; 0.2 per cent nitrofurazone; 0.1, 0.5 and 1 per cent chlorhexidine; 2.2 per cent cerium nitrate; 10 per cent povidone iodine; and 1 per cent silver sulphadiazine with 2.2 per cent cerium nitrate were evaluated in vitro. The evaluation included the minimum inhibitory concentration (MIC) against 100 microorganisms isolated from burn patients, the chronology of the bacterial activity against Ps. aeruginosa and Staph. aureus and the penetration strength of the creams through a novel in vitro model contaminated with 17 microorganisms of different species isolated from burn patients. The results revealed that 0.5 per cent or 1 per cent chlorhexidine, 2.2 per cent cerium nitrate, and 1 per cent silver sulphadiazine with 2.2 per cent cerium nitrate were the creams which were effective at the highest dilutions. 0.5 per cent chlorhexidine and 10 per cent povidone iodine had the greater bactericidal activity. Finally, 0.2 per cent nitrofurazone showed greater penetration strength within the eschar model in comparison with the weaker penetration of 0.5 per cent and 1 per cent chlorhexidine and the absence of penetration by the rest of the antibacterial creams. |
| doi_str_mv | 10.1016/0305-4179(92)90118-E |
| format | Article |
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The evaluation included the minimum inhibitory concentration (MIC) against 100 microorganisms isolated from burn patients, the chronology of the bacterial activity against Ps. aeruginosa and Staph. aureus and the penetration strength of the creams through a novel in vitro model contaminated with 17 microorganisms of different species isolated from burn patients. The results revealed that 0.5 per cent or 1 per cent chlorhexidine, 2.2 per cent cerium nitrate, and 1 per cent silver sulphadiazine with 2.2 per cent cerium nitrate were the creams which were effective at the highest dilutions. 0.5 per cent chlorhexidine and 10 per cent povidone iodine had the greater bactericidal activity. Finally, 0.2 per cent nitrofurazone showed greater penetration strength within the eschar model in comparison with the weaker penetration of 0.5 per cent and 1 per cent chlorhexidine and the absence of penetration by the rest of the antibacterial creams.</description><identifier>ISSN: 0305-4179</identifier><identifier>EISSN: 1879-1409</identifier><identifier>DOI: 10.1016/0305-4179(92)90118-E</identifier><identifier>PMID: 1558672</identifier><identifier>CODEN: BURND8</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Administration, Topical ; Anti-Bacterial Agents - pharmacokinetics ; Anti-Bacterial Agents - pharmacology ; Bacteria - drug effects ; Bacteria - isolation & purification ; Biological and medical sciences ; Biological Dressings ; Burns ; Burns - drug therapy ; Burns - microbiology ; Drug Resistance, Microbial ; Humans ; In Vitro Techniques ; Medical sciences ; Microbial Sensitivity Tests ; Ointments ; Pseudomonas aeruginosa - drug effects ; Pseudomonas aeruginosa - isolation & purification ; Skin - metabolism ; Skin - microbiology ; Staphylococcus aureus - drug effects ; Staphylococcus aureus - isolation & purification ; Traumas. 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The evaluation included the minimum inhibitory concentration (MIC) against 100 microorganisms isolated from burn patients, the chronology of the bacterial activity against Ps. aeruginosa and Staph. aureus and the penetration strength of the creams through a novel in vitro model contaminated with 17 microorganisms of different species isolated from burn patients. The results revealed that 0.5 per cent or 1 per cent chlorhexidine, 2.2 per cent cerium nitrate, and 1 per cent silver sulphadiazine with 2.2 per cent cerium nitrate were the creams which were effective at the highest dilutions. 0.5 per cent chlorhexidine and 10 per cent povidone iodine had the greater bactericidal activity. Finally, 0.2 per cent nitrofurazone showed greater penetration strength within the eschar model in comparison with the weaker penetration of 0.5 per cent and 1 per cent chlorhexidine and the absence of penetration by the rest of the antibacterial creams.</description><subject>Administration, Topical</subject><subject>Anti-Bacterial Agents - pharmacokinetics</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Bacteria - drug effects</subject><subject>Bacteria - isolation & purification</subject><subject>Biological and medical sciences</subject><subject>Biological Dressings</subject><subject>Burns</subject><subject>Burns - drug therapy</subject><subject>Burns - microbiology</subject><subject>Drug Resistance, Microbial</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Ointments</subject><subject>Pseudomonas aeruginosa - drug effects</subject><subject>Pseudomonas aeruginosa - isolation & purification</subject><subject>Skin - metabolism</subject><subject>Skin - microbiology</subject><subject>Staphylococcus aureus - drug effects</subject><subject>Staphylococcus aureus - isolation & purification</subject><subject>Traumas. 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Diseases due to physical agents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Herruzo-Cabrera, R.</creatorcontrib><creatorcontrib>Garcia-Torres, V.</creatorcontrib><creatorcontrib>Rey-Calero, J.</creatorcontrib><creatorcontrib>Vizcaino-Alcaide, M.J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Burns</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Herruzo-Cabrera, R.</au><au>Garcia-Torres, V.</au><au>Rey-Calero, J.</au><au>Vizcaino-Alcaide, M.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of the penetration strength, bactericidal efficacy and spectrum of action of several antimicrobial creams against isolated microorganisms in a burn centre</atitle><jtitle>Burns</jtitle><addtitle>Burns</addtitle><date>1992-02-01</date><risdate>1992</risdate><volume>18</volume><issue>1</issue><spage>39</spage><epage>44</epage><pages>39-44</pages><issn>0305-4179</issn><eissn>1879-1409</eissn><coden>BURND8</coden><abstract>The antibacterial activity of eight antiseptic creams: 1 per cent silver sulphadiazine; 0.2 per cent nitrofurazone; 0.1, 0.5 and 1 per cent chlorhexidine; 2.2 per cent cerium nitrate; 10 per cent povidone iodine; and 1 per cent silver sulphadiazine with 2.2 per cent cerium nitrate were evaluated in vitro. The evaluation included the minimum inhibitory concentration (MIC) against 100 microorganisms isolated from burn patients, the chronology of the bacterial activity against Ps. aeruginosa and Staph. aureus and the penetration strength of the creams through a novel in vitro model contaminated with 17 microorganisms of different species isolated from burn patients. The results revealed that 0.5 per cent or 1 per cent chlorhexidine, 2.2 per cent cerium nitrate, and 1 per cent silver sulphadiazine with 2.2 per cent cerium nitrate were the creams which were effective at the highest dilutions. 0.5 per cent chlorhexidine and 10 per cent povidone iodine had the greater bactericidal activity. 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| ispartof | Burns, 1992-02, Vol.18 (1), p.39-44 |
| issn | 0305-4179 1879-1409 |
| language | eng |
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| subjects | Administration, Topical Anti-Bacterial Agents - pharmacokinetics Anti-Bacterial Agents - pharmacology Bacteria - drug effects Bacteria - isolation & purification Biological and medical sciences Biological Dressings Burns Burns - drug therapy Burns - microbiology Drug Resistance, Microbial Humans In Vitro Techniques Medical sciences Microbial Sensitivity Tests Ointments Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - isolation & purification Skin - metabolism Skin - microbiology Staphylococcus aureus - drug effects Staphylococcus aureus - isolation & purification Traumas. Diseases due to physical agents |
| title | Evaluation of the penetration strength, bactericidal efficacy and spectrum of action of several antimicrobial creams against isolated microorganisms in a burn centre |
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