Up-regulated biosynthesis and expression of endothelial cell vitronectin receptor enhances cancer cell adhesion

Extravasation of circulating cancer cells during metastasis is thought to involve adhesion to the vascular endothelium. To characterize this process, we measured the attachment of A549 human lung carcinoma cells to monolayers of cultured human umbilical vein endothelial cells. Pretreatment of the en...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1992-04, Vol.52 (8), p.2202-2208
Hauptverfasser:	LAFRENIE, R. M, PODOR, T. J, BUCHANAN, M. R, WILLIAM ORR, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies - metabolism Biological and medical sciences Blotting, Northern Cell Adhesion - drug effects Cells, Cultured Dissemination Endothelium Flow Cytometry Fluorescent Antibody Technique Interleukin-1 - antagonists & inhibitors Interleukin-1 - pharmacology Medical sciences Molecular Weight Oligopeptides - pharmacology Precipitin Tests Receptors, Immunologic - analysis Receptors, Immunologic - biosynthesis Receptors, Vitronectin Tumor cell Tumors Up-Regulation
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