Order of substrate binding in bacterial phenylalanine hydroxylase and its mechanistic implication for pterin-dependent oxygenases

Phenylalanine hydroxylase (PAH) is a pterin-dependent non-heme metalloenzyme that catalyzes the oxidation of phenylalanine to tyrosine, which is the rate-limiting step in the catabolism of Phe. Chromobacterium violaceum phenylalanine hydroxylase (cPAH) has been prepared and its steady-state mechanis...

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Veröffentlicht in:	Journal of biological inorganic chemistry 2003-01, Vol.8 (1-2), p.121-128
Hauptverfasser:	Volner, Alon, Zoidakis, Jérôme, Abu-Omar, Mahdi M
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Binding, Competitive Catalysis Chromobacterium - enzymology Iron - metabolism Kinetics Oxygen - metabolism Oxygenases - metabolism Phenylalanine Hydroxylase - chemistry Phenylalanine Hydroxylase - genetics Phenylalanine Hydroxylase - metabolism Protein Binding Pteridines - chemistry Pteridines - metabolism Pterins - metabolism Recombinant Proteins - chemistry Recombinant Proteins - metabolism Substrate Specificity
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