MUC1 mucin expression in follicular dendritic cells and lymphoepithelial lesions of gastric mucosa-associated lymphoid tissue lymphoma
Membrane‐associated mucin MUC1 is expressed in various adenocarcinoma cells and active T lymphocytes. We tried to find out whether MUC1 is expressed in gastric mucosa‐associated lymphoid tissue (MALT) lymphoma lesion. MUC1 was not expressed in infiltrating T lymphocytes; however, MUC1 was found on t...
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| Veröffentlicht in: | Pathology international 2002-11, Vol.52 (11), p.691-701 |
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| creator | Taki, Chiaki Kitajima, Shinichi Sueyoshi, Kazunobu Yonezawa, Suguru Tanaka, Sadao Sakoda, Koro Irimura, Tatsuro Sato, Eiichi Goto, Masamichi |
| description | Membrane‐associated mucin MUC1 is expressed in various adenocarcinoma cells and active T lymphocytes. We tried to find out whether MUC1 is expressed in gastric mucosa‐associated lymphoid tissue (MALT) lymphoma lesion. MUC1 was not expressed in infiltrating T lymphocytes; however, MUC1 was found on the cell surface of follicular dendritic cells (FDC) of germinal centers and in the epithelial cytoplasm of lymphoepithelial lesion (LEL) of the lymphoma, which were immunohistochemically detected by monoclonal antibodies DF3 and MY.1E12. MUC1 was also expressed in the FDC of control cases (gastrectomy specimen containing reactive lymphoid follicles, n = 10, MUC1/DF3, 100%; MUC1/MY.1E12, 40%), and FDC in MALT lymphomas (n = 59) showed lower MUC1 expression rates (MUC1/DF3, 32%; MUC1/MY.1E12, 0%) than the control (P |
| doi_str_mv | 10.1046/j.1440-1827.2002.01411.x |
| format | Article |
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We tried to find out whether MUC1 is expressed in gastric mucosa‐associated lymphoid tissue (MALT) lymphoma lesion. MUC1 was not expressed in infiltrating T lymphocytes; however, MUC1 was found on the cell surface of follicular dendritic cells (FDC) of germinal centers and in the epithelial cytoplasm of lymphoepithelial lesion (LEL) of the lymphoma, which were immunohistochemically detected by monoclonal antibodies DF3 and MY.1E12. MUC1 was also expressed in the FDC of control cases (gastrectomy specimen containing reactive lymphoid follicles, n = 10, MUC1/DF3, 100%; MUC1/MY.1E12, 40%), and FDC in MALT lymphomas (n = 59) showed lower MUC1 expression rates (MUC1/DF3, 32%; MUC1/MY.1E12, 0%) than the control (P < 0.001). Lymphoepithelial lesion in the low‐grade MALT lymphomas (n = 23) showed a higher MUC1/DF3 expression rate (30%) than those in the high‐grade MALT lymphomas (n = 36; 6%; P < 0.05). T lymphocytes in the surface mucosa were more frequent in MALT lymphoma (91.4 ± 80.6/unit area) than those in the control (20.0 ± 23.6) (P < 0.001). S100‐positive dendritic cells around LEL were more frequent in the low‐grade (19.0 ± 9.4/unit area) than in the high‐grade (11.7 ± 9.7) (P < 0.005). This study demonstrated MUC1 mucin expression on FDC for the first time. Mucosa‐associated lymphoid tissue lymphoma, especially low‐grade, shows immunologically active state, where FDC MUC1 expression may be suppressed by some factors released from lymphoma cells. Further study to elucidate the pathogenetic role of MUC1 in MALT lymphoma is necessary.</description><identifier>ISSN: 1320-5463</identifier><identifier>EISSN: 1440-1827</identifier><identifier>DOI: 10.1046/j.1440-1827.2002.01411.x</identifier><identifier>PMID: 12685546</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Science Pty</publisher><subject>Aged ; Antibodies, Monoclonal - immunology ; Biomarkers, Tumor - metabolism ; Cell Count ; Dendritic Cells, Follicular - metabolism ; Dendritic Cells, Follicular - pathology ; Female ; follicular dendritic cell ; Germinal Center - metabolism ; Germinal Center - pathology ; Humans ; Immunoenzyme Techniques ; immunology ; Lymphoma, B-Cell, Marginal Zone - metabolism ; Lymphoma, B-Cell, Marginal Zone - pathology ; Male ; malignant lymphoma ; Middle Aged ; mucin antigen ; Mucin-1 - metabolism ; mucosa-associated lymphoid tissue ; S100 Proteins - metabolism ; stomach ; Stomach Neoplasms - metabolism ; Stomach Neoplasms - pathology ; T-Lymphocytes - pathology</subject><ispartof>Pathology international, 2002-11, Vol.52 (11), p.691-701</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5221-13e55dd616e4901fb6fea26b34df99198fb76210474429143c698a9242fa9ce33</citedby><cites>FETCH-LOGICAL-c5221-13e55dd616e4901fb6fea26b34df99198fb76210474429143c698a9242fa9ce33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1440-1827.2002.01411.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1440-1827.2002.01411.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12685546$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Taki, Chiaki</creatorcontrib><creatorcontrib>Kitajima, Shinichi</creatorcontrib><creatorcontrib>Sueyoshi, Kazunobu</creatorcontrib><creatorcontrib>Yonezawa, Suguru</creatorcontrib><creatorcontrib>Tanaka, Sadao</creatorcontrib><creatorcontrib>Sakoda, Koro</creatorcontrib><creatorcontrib>Irimura, Tatsuro</creatorcontrib><creatorcontrib>Sato, Eiichi</creatorcontrib><creatorcontrib>Goto, Masamichi</creatorcontrib><title>MUC1 mucin expression in follicular dendritic cells and lymphoepithelial lesions of gastric mucosa-associated lymphoid tissue lymphoma</title><title>Pathology international</title><addtitle>Pathol Int</addtitle><description>Membrane‐associated mucin MUC1 is expressed in various adenocarcinoma cells and active T lymphocytes. We tried to find out whether MUC1 is expressed in gastric mucosa‐associated lymphoid tissue (MALT) lymphoma lesion. MUC1 was not expressed in infiltrating T lymphocytes; however, MUC1 was found on the cell surface of follicular dendritic cells (FDC) of germinal centers and in the epithelial cytoplasm of lymphoepithelial lesion (LEL) of the lymphoma, which were immunohistochemically detected by monoclonal antibodies DF3 and MY.1E12. MUC1 was also expressed in the FDC of control cases (gastrectomy specimen containing reactive lymphoid follicles, n = 10, MUC1/DF3, 100%; MUC1/MY.1E12, 40%), and FDC in MALT lymphomas (n = 59) showed lower MUC1 expression rates (MUC1/DF3, 32%; MUC1/MY.1E12, 0%) than the control (P < 0.001). Lymphoepithelial lesion in the low‐grade MALT lymphomas (n = 23) showed a higher MUC1/DF3 expression rate (30%) than those in the high‐grade MALT lymphomas (n = 36; 6%; P < 0.05). T lymphocytes in the surface mucosa were more frequent in MALT lymphoma (91.4 ± 80.6/unit area) than those in the control (20.0 ± 23.6) (P < 0.001). S100‐positive dendritic cells around LEL were more frequent in the low‐grade (19.0 ± 9.4/unit area) than in the high‐grade (11.7 ± 9.7) (P < 0.005). This study demonstrated MUC1 mucin expression on FDC for the first time. Mucosa‐associated lymphoid tissue lymphoma, especially low‐grade, shows immunologically active state, where FDC MUC1 expression may be suppressed by some factors released from lymphoma cells. Further study to elucidate the pathogenetic role of MUC1 in MALT lymphoma is necessary.</description><subject>Aged</subject><subject>Antibodies, Monoclonal - immunology</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Cell Count</subject><subject>Dendritic Cells, Follicular - metabolism</subject><subject>Dendritic Cells, Follicular - pathology</subject><subject>Female</subject><subject>follicular dendritic cell</subject><subject>Germinal Center - metabolism</subject><subject>Germinal Center - pathology</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>immunology</subject><subject>Lymphoma, B-Cell, Marginal Zone - metabolism</subject><subject>Lymphoma, B-Cell, Marginal Zone - pathology</subject><subject>Male</subject><subject>malignant lymphoma</subject><subject>Middle Aged</subject><subject>mucin antigen</subject><subject>Mucin-1 - metabolism</subject><subject>mucosa-associated lymphoid tissue</subject><subject>S100 Proteins - metabolism</subject><subject>stomach</subject><subject>Stomach Neoplasms - metabolism</subject><subject>Stomach Neoplasms - pathology</subject><subject>T-Lymphocytes - pathology</subject><issn>1320-5463</issn><issn>1440-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1u1DAUhS0EomXgFZBX7BL8FydesIARtBWlZUHVpeVJbqgH5wffRJ15gT43DjOUbReW79U937F8LiGUs5wzpd9vc64Uy3glylwwJnLGFef57hk5fRw8T7UULCuUlifkFeKWMV5KzV6SEy50VaTBKXn4drPmtJtr31PYjREQ_dDT1LVDCL6eg4u0gb6JfvI1rSEEpK5vaNh3490Ao5_uIHgXaICFRDq09KfDKSZ1sh3QZQ5xqL2b4B_lGzp5xBmOfedekxetCwhvjveK3Hz5_GN9nl1en12sP15mdSEEz7iEomgazTUow3i70S04oTdSNa0x3FTtptQiRVQqJQxXstamckYo0TpTg5Qr8u7gO8bh9ww42c7j8inXwzCjLUVVSpPOilQHYR0HxAitHaPvXNxbzuyyA7u1S9R2idouO7B_d2B3CX17fGPedND8B4-hJ8GHg-DeB9g_2dh-v7haqsRnB97jBLtH3sVfVpeyLOzt1ZktP90W5-Yrs0L-AYE9ppU</recordid><startdate>200211</startdate><enddate>200211</enddate><creator>Taki, Chiaki</creator><creator>Kitajima, Shinichi</creator><creator>Sueyoshi, Kazunobu</creator><creator>Yonezawa, Suguru</creator><creator>Tanaka, Sadao</creator><creator>Sakoda, Koro</creator><creator>Irimura, Tatsuro</creator><creator>Sato, Eiichi</creator><creator>Goto, Masamichi</creator><general>Blackwell Science Pty</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200211</creationdate><title>MUC1 mucin expression in follicular dendritic cells and lymphoepithelial lesions of gastric mucosa-associated lymphoid tissue lymphoma</title><author>Taki, Chiaki ; Kitajima, Shinichi ; Sueyoshi, Kazunobu ; Yonezawa, Suguru ; Tanaka, Sadao ; Sakoda, Koro ; Irimura, Tatsuro ; Sato, Eiichi ; Goto, Masamichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5221-13e55dd616e4901fb6fea26b34df99198fb76210474429143c698a9242fa9ce33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Aged</topic><topic>Antibodies, Monoclonal - immunology</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Cell Count</topic><topic>Dendritic Cells, Follicular - metabolism</topic><topic>Dendritic Cells, Follicular - pathology</topic><topic>Female</topic><topic>follicular dendritic cell</topic><topic>Germinal Center - metabolism</topic><topic>Germinal Center - pathology</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>immunology</topic><topic>Lymphoma, B-Cell, Marginal Zone - metabolism</topic><topic>Lymphoma, B-Cell, Marginal Zone - pathology</topic><topic>Male</topic><topic>malignant lymphoma</topic><topic>Middle Aged</topic><topic>mucin antigen</topic><topic>Mucin-1 - metabolism</topic><topic>mucosa-associated lymphoid tissue</topic><topic>S100 Proteins - metabolism</topic><topic>stomach</topic><topic>Stomach Neoplasms - metabolism</topic><topic>Stomach Neoplasms - pathology</topic><topic>T-Lymphocytes - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Taki, Chiaki</creatorcontrib><creatorcontrib>Kitajima, Shinichi</creatorcontrib><creatorcontrib>Sueyoshi, Kazunobu</creatorcontrib><creatorcontrib>Yonezawa, Suguru</creatorcontrib><creatorcontrib>Tanaka, Sadao</creatorcontrib><creatorcontrib>Sakoda, Koro</creatorcontrib><creatorcontrib>Irimura, Tatsuro</creatorcontrib><creatorcontrib>Sato, Eiichi</creatorcontrib><creatorcontrib>Goto, Masamichi</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pathology international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Taki, Chiaki</au><au>Kitajima, Shinichi</au><au>Sueyoshi, Kazunobu</au><au>Yonezawa, Suguru</au><au>Tanaka, Sadao</au><au>Sakoda, Koro</au><au>Irimura, Tatsuro</au><au>Sato, Eiichi</au><au>Goto, Masamichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MUC1 mucin expression in follicular dendritic cells and lymphoepithelial lesions of gastric mucosa-associated lymphoid tissue lymphoma</atitle><jtitle>Pathology international</jtitle><addtitle>Pathol Int</addtitle><date>2002-11</date><risdate>2002</risdate><volume>52</volume><issue>11</issue><spage>691</spage><epage>701</epage><pages>691-701</pages><issn>1320-5463</issn><eissn>1440-1827</eissn><abstract>Membrane‐associated mucin MUC1 is expressed in various adenocarcinoma cells and active T lymphocytes. We tried to find out whether MUC1 is expressed in gastric mucosa‐associated lymphoid tissue (MALT) lymphoma lesion. MUC1 was not expressed in infiltrating T lymphocytes; however, MUC1 was found on the cell surface of follicular dendritic cells (FDC) of germinal centers and in the epithelial cytoplasm of lymphoepithelial lesion (LEL) of the lymphoma, which were immunohistochemically detected by monoclonal antibodies DF3 and MY.1E12. MUC1 was also expressed in the FDC of control cases (gastrectomy specimen containing reactive lymphoid follicles, n = 10, MUC1/DF3, 100%; MUC1/MY.1E12, 40%), and FDC in MALT lymphomas (n = 59) showed lower MUC1 expression rates (MUC1/DF3, 32%; MUC1/MY.1E12, 0%) than the control (P < 0.001). Lymphoepithelial lesion in the low‐grade MALT lymphomas (n = 23) showed a higher MUC1/DF3 expression rate (30%) than those in the high‐grade MALT lymphomas (n = 36; 6%; P < 0.05). T lymphocytes in the surface mucosa were more frequent in MALT lymphoma (91.4 ± 80.6/unit area) than those in the control (20.0 ± 23.6) (P < 0.001). S100‐positive dendritic cells around LEL were more frequent in the low‐grade (19.0 ± 9.4/unit area) than in the high‐grade (11.7 ± 9.7) (P < 0.005). This study demonstrated MUC1 mucin expression on FDC for the first time. Mucosa‐associated lymphoid tissue lymphoma, especially low‐grade, shows immunologically active state, where FDC MUC1 expression may be suppressed by some factors released from lymphoma cells. Further study to elucidate the pathogenetic role of MUC1 in MALT lymphoma is necessary.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Science Pty</pub><pmid>12685546</pmid><doi>10.1046/j.1440-1827.2002.01411.x</doi><tpages>11</tpages></addata></record> |
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| subjects | Aged Antibodies, Monoclonal - immunology Biomarkers, Tumor - metabolism Cell Count Dendritic Cells, Follicular - metabolism Dendritic Cells, Follicular - pathology Female follicular dendritic cell Germinal Center - metabolism Germinal Center - pathology Humans Immunoenzyme Techniques immunology Lymphoma, B-Cell, Marginal Zone - metabolism Lymphoma, B-Cell, Marginal Zone - pathology Male malignant lymphoma Middle Aged mucin antigen Mucin-1 - metabolism mucosa-associated lymphoid tissue S100 Proteins - metabolism stomach Stomach Neoplasms - metabolism Stomach Neoplasms - pathology T-Lymphocytes - pathology |
| title | MUC1 mucin expression in follicular dendritic cells and lymphoepithelial lesions of gastric mucosa-associated lymphoid tissue lymphoma |
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