Imaging of medullary carcinoma of the thyroid using 111In-labelled anti-CEA monoclonal antibody fragments
The distribution of In-labelled anti-carcinoembryonic antigen (CEA) monoclonal antibody fragments [F(Ab‘)2] was studied in five patients either with known inoperable medullary carcinoma of the thyroid (MCT) or evidence of recurrence/metastases based on elevated calcitonin (hCT) levels. All five case...
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| Veröffentlicht in: | Nuclear medicine communications 1992-03, Vol.13 (3), p.142-148 |
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| container_title | Nuclear medicine communications |
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| creator | OʼBYRNE, K J HAMILTON, D ROBINSON, I SWEENEY, E FREYNE, P J CULLEN, M J |
| description | The distribution of In-labelled anti-carcinoembryonic antigen (CEA) monoclonal antibody fragments [F(Ab‘)2] was studied in five patients either with known inoperable medullary carcinoma of the thyroid (MCT) or evidence of recurrence/metastases based on elevated calcitonin (hCT) levels. All five cases had elevated serum CEA levels and positive immunohistochemical stains for both hCT and CEA prior to scintigraphy. In two patients with identified inoperable disease both planar and SPECT scans were positive. In the remaining three patients, where the recurrence/metastatic sites were unknown, SPECT images were positive in two. Of these, only one had positive planar images. These results indicate that “In-labelled anti-CEA F(Ab’)2 scintigraphy, especially in conjunction with SPECT, is useful for the diagnostic evaluation of patients with MCT. The limiting factor of this technique is the high level of non-specific uptake, particularly in the liver, but improvements in the specificity of newer anti-CEA antibodies and the ability to label these with Tc is addressing this problem. |
| doi_str_mv | 10.1097/00006231-199203000-00004 |
| format | Article |
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All five cases had elevated serum CEA levels and positive immunohistochemical stains for both hCT and CEA prior to scintigraphy. In two patients with identified inoperable disease both planar and SPECT scans were positive. In the remaining three patients, where the recurrence/metastatic sites were unknown, SPECT images were positive in two. Of these, only one had positive planar images. These results indicate that “In-labelled anti-CEA F(Ab’)2 scintigraphy, especially in conjunction with SPECT, is useful for the diagnostic evaluation of patients with MCT. The limiting factor of this technique is the high level of non-specific uptake, particularly in the liver, but improvements in the specificity of newer anti-CEA antibodies and the ability to label these with Tc is addressing this problem.</description><identifier>ISSN: 0143-3636</identifier><identifier>EISSN: 1473-5628</identifier><identifier>DOI: 10.1097/00006231-199203000-00004</identifier><identifier>PMID: 1557212</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott-Raven Publishers</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Carcinoma - diagnostic imaging ; Endocrine glands. Genital system. Mammary gland ; Female ; Humans ; Indium Radioisotopes ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Middle Aged ; Radioimmunodetection ; Radionuclide investigations ; Thyroid Neoplasms - diagnostic imaging ; Tomography, Emission-Computed, Single-Photon</subject><ispartof>Nuclear medicine communications, 1992-03, Vol.13 (3), p.142-148</ispartof><rights>Lippincott-Raven Publishers.</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2314-b41b31f2da8f179cf186d8f93e8380eee47dae0795e813e9cce9066c8dbce9773</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5165361$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1557212$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>OʼBYRNE, K J</creatorcontrib><creatorcontrib>HAMILTON, D</creatorcontrib><creatorcontrib>ROBINSON, I</creatorcontrib><creatorcontrib>SWEENEY, E</creatorcontrib><creatorcontrib>FREYNE, P J</creatorcontrib><creatorcontrib>CULLEN, M J</creatorcontrib><title>Imaging of medullary carcinoma of the thyroid using 111In-labelled anti-CEA monoclonal antibody fragments</title><title>Nuclear medicine communications</title><addtitle>Nucl Med Commun</addtitle><description>The distribution of In-labelled anti-carcinoembryonic antigen (CEA) monoclonal antibody fragments [F(Ab‘)2] was studied in five patients either with known inoperable medullary carcinoma of the thyroid (MCT) or evidence of recurrence/metastases based on elevated calcitonin (hCT) levels. All five cases had elevated serum CEA levels and positive immunohistochemical stains for both hCT and CEA prior to scintigraphy. In two patients with identified inoperable disease both planar and SPECT scans were positive. In the remaining three patients, where the recurrence/metastatic sites were unknown, SPECT images were positive in two. Of these, only one had positive planar images. These results indicate that “In-labelled anti-CEA F(Ab’)2 scintigraphy, especially in conjunction with SPECT, is useful for the diagnostic evaluation of patients with MCT. The limiting factor of this technique is the high level of non-specific uptake, particularly in the liver, but improvements in the specificity of newer anti-CEA antibodies and the ability to label these with Tc is addressing this problem.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Carcinoma - diagnostic imaging</subject><subject>Endocrine glands. Genital system. Mammary gland</subject><subject>Female</subject><subject>Humans</subject><subject>Indium Radioisotopes</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Radioimmunodetection</subject><subject>Radionuclide investigations</subject><subject>Thyroid Neoplasms - diagnostic imaging</subject><subject>Tomography, Emission-Computed, Single-Photon</subject><issn>0143-3636</issn><issn>1473-5628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kcFu3CAQhlHVKN0meYRKPlS90TJgAz5Gq6RdKVIvzRlhPN51iyEFW9G-fXF2m56KhIB_voGZH0IqYJ-BteoLK0NyARTaljNRTnSV6jdkA7UStJFcvyUbBrWgQgr5jrzP-WchtJDqklxC0ygOfEPG3WT3Y9hXcagm7BfvbTpWziY3hjjZVZ4PWOYxxbGvlryyALAL1NsOvce-smEe6fbutppiiM7HYP2L1sX-WA3J7icMc74mF4P1GW_O6xV5vL_7sf1GH75_3W1vH6gr_dS0q6ETMPDe6gFU6wbQstdDK1ALzRCxVr1FptoGNQhsncOWSel035WdUuKKfDrd-5Ti7wXzbKYxu1KpDRiXbBTXijMOBdQn0KWYc8LBPKVxKu0bYGZ12fx12by6_CLVJfXD-Y2lK679SzzZWuIfz3GbnfXFg-DG_Io1IBsh1wrqE_Yc_Ywp__LLMyZzQOvng_nfH4s_p0WUXg</recordid><startdate>199203</startdate><enddate>199203</enddate><creator>OʼBYRNE, K J</creator><creator>HAMILTON, D</creator><creator>ROBINSON, I</creator><creator>SWEENEY, E</creator><creator>FREYNE, P J</creator><creator>CULLEN, M J</creator><general>Lippincott-Raven Publishers</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199203</creationdate><title>Imaging of medullary carcinoma of the thyroid using 111In-labelled anti-CEA monoclonal antibody fragments</title><author>OʼBYRNE, K J ; HAMILTON, D ; ROBINSON, I ; SWEENEY, E ; FREYNE, P J ; CULLEN, M J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2314-b41b31f2da8f179cf186d8f93e8380eee47dae0795e813e9cce9066c8dbce9773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Carcinoma - diagnostic imaging</topic><topic>Endocrine glands. Genital system. Mammary gland</topic><topic>Female</topic><topic>Humans</topic><topic>Indium Radioisotopes</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Radioimmunodetection</topic><topic>Radionuclide investigations</topic><topic>Thyroid Neoplasms - diagnostic imaging</topic><topic>Tomography, Emission-Computed, Single-Photon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>OʼBYRNE, K J</creatorcontrib><creatorcontrib>HAMILTON, D</creatorcontrib><creatorcontrib>ROBINSON, I</creatorcontrib><creatorcontrib>SWEENEY, E</creatorcontrib><creatorcontrib>FREYNE, P J</creatorcontrib><creatorcontrib>CULLEN, M J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nuclear medicine communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>OʼBYRNE, K J</au><au>HAMILTON, D</au><au>ROBINSON, I</au><au>SWEENEY, E</au><au>FREYNE, P J</au><au>CULLEN, M J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Imaging of medullary carcinoma of the thyroid using 111In-labelled anti-CEA monoclonal antibody fragments</atitle><jtitle>Nuclear medicine communications</jtitle><addtitle>Nucl Med Commun</addtitle><date>1992-03</date><risdate>1992</risdate><volume>13</volume><issue>3</issue><spage>142</spage><epage>148</epage><pages>142-148</pages><issn>0143-3636</issn><eissn>1473-5628</eissn><abstract>The distribution of In-labelled anti-carcinoembryonic antigen (CEA) monoclonal antibody fragments [F(Ab‘)2] was studied in five patients either with known inoperable medullary carcinoma of the thyroid (MCT) or evidence of recurrence/metastases based on elevated calcitonin (hCT) levels. All five cases had elevated serum CEA levels and positive immunohistochemical stains for both hCT and CEA prior to scintigraphy. In two patients with identified inoperable disease both planar and SPECT scans were positive. In the remaining three patients, where the recurrence/metastatic sites were unknown, SPECT images were positive in two. Of these, only one had positive planar images. These results indicate that “In-labelled anti-CEA F(Ab’)2 scintigraphy, especially in conjunction with SPECT, is useful for the diagnostic evaluation of patients with MCT. The limiting factor of this technique is the high level of non-specific uptake, particularly in the liver, but improvements in the specificity of newer anti-CEA antibodies and the ability to label these with Tc is addressing this problem.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>1557212</pmid><doi>10.1097/00006231-199203000-00004</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0143-3636 |
| ispartof | Nuclear medicine communications, 1992-03, Vol.13 (3), p.142-148 |
| issn | 0143-3636 1473-5628 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Aged Biological and medical sciences Carcinoma - diagnostic imaging Endocrine glands. Genital system. Mammary gland Female Humans Indium Radioisotopes Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged Radioimmunodetection Radionuclide investigations Thyroid Neoplasms - diagnostic imaging Tomography, Emission-Computed, Single-Photon |
| title | Imaging of medullary carcinoma of the thyroid using 111In-labelled anti-CEA monoclonal antibody fragments |
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