Influence of dietary fat on the pharmacodynamics of propafenone in isolated, perfused rabbit hearts

The fatty acid composition of the phospholipids in sarcolemma may significantly influence cell membrane functions. We evaluated the effects of dietary fat on the pharmacodynamics of the antiarrhythmic drug propafenone in isolated, perfused rabbit hearts. Three groups of weanling rabbits (n = 9 each...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 1992-04, Vol.85 (4), p.1501-1509
Hauptverfasser:	GILLIS, A. M, KEASHLY, R, WATSON, P. A, MATHISON, H. J, PARSONS, H. G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiarythmic agents Biological and medical sciences Cardiovascular system Dietary Fats - pharmacology Fatty Acids - analysis Heart - drug effects Heart - physiology Heart Conduction System - drug effects Heart Conduction System - physiology Medical sciences Myocardium - ultrastructure Pharmacology. Drug treatments Phospholipids - analysis Propafenone - pharmacokinetics Propafenone - pharmacology Rabbits Sarcolemma - chemistry Ventricular Function - drug effects
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