Pulmonary Sequelae at Six Months following Extracorporeal Membrane Oxygenation
Mechanical assisted ventilation for neonatal respiratory failure is associated with residual lung disease. Because ECMO rests the lungs, it has been suggested that ECMO will prevent chronic lung disease in survivors. To determine whether or not ECMO survivors have evidence of pulmonary sequelae, we...
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| Veröffentlicht in: | Chest 1992-04, Vol.101 (4), p.1086-1090 |
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| creator | Garg, Meena Kurzner, Sharon I. Bautista, Daisy B. Lew, Cheryl D. Ramos, Angela D. Platzker, Arnold C.G. Keens, Thomas G. |
| description | Mechanical assisted ventilation for neonatal respiratory failure is associated with residual lung disease. Because ECMO rests the lungs, it has been suggested that ECMO will prevent chronic lung disease in survivors. To determine whether or not ECMO survivors have evidence of pulmonary sequelae, we studied 19 infants who were treated with ECMO for neonatal respiratory failure. Ten infants still required supplemental oxygen or pulmonary medications or both to treat clinical lung disease during the first six months of life. Thoracic gas volume was normal. Pulmonary mechanics in ECMO survivors were compared with those of 13 preterm infants with BPD at similar age. We conclude that a significant proportion of ECMO survivors have residual abnormalities in pulmonary mechanics at 6 months of age. We speculate that neonatal lung injury due to meconium aspiration and other causes is a more important determinant of abnormal pulmonary sequelae than the method of treatment. |
| doi_str_mv | 10.1378/chest.101.4.1086 |
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Because ECMO rests the lungs, it has been suggested that ECMO will prevent chronic lung disease in survivors. To determine whether or not ECMO survivors have evidence of pulmonary sequelae, we studied 19 infants who were treated with ECMO for neonatal respiratory failure. Ten infants still required supplemental oxygen or pulmonary medications or both to treat clinical lung disease during the first six months of life. Thoracic gas volume was normal. Pulmonary mechanics in ECMO survivors were compared with those of 13 preterm infants with BPD at similar age. We conclude that a significant proportion of ECMO survivors have residual abnormalities in pulmonary mechanics at 6 months of age. We speculate that neonatal lung injury due to meconium aspiration and other causes is a more important determinant of abnormal pulmonary sequelae than the method of treatment.</description><identifier>ISSN: 0012-3692</identifier><identifier>EISSN: 1931-3543</identifier><identifier>DOI: 10.1378/chest.101.4.1086</identifier><identifier>PMID: 1555425</identifier><identifier>CODEN: CHETBF</identifier><language>eng</language><publisher>Northbrook, IL: Elsevier Inc</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Bronchopulmonary Dysplasia - complications ; Bronchopulmonary Dysplasia - therapy ; Emergency and intensive care: neonates and children. Prematurity. Sudden death ; Extracorporeal Membrane Oxygenation - adverse effects ; Extracorporeal Membrane Oxygenation - methods ; Follow-Up Studies ; Humans ; Infant ; Infant, Newborn ; Intensive care medicine ; Lung Diseases - diagnosis ; Lung Diseases - epidemiology ; Lung Diseases - etiology ; Meconium Aspiration Syndrome - complications ; Meconium Aspiration Syndrome - therapy ; Medical sciences ; Persistent Fetal Circulation Syndrome - complications ; Persistent Fetal Circulation Syndrome - therapy ; Respiratory Distress Syndrome, Newborn - complications ; Respiratory Distress Syndrome, Newborn - therapy ; Respiratory Function Tests - methods ; Respiratory Mechanics</subject><ispartof>Chest, 1992-04, Vol.101 (4), p.1086-1090</ispartof><rights>1992 The American College of Chest Physicians</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c330t-e36cbd4b62569901fb5ab9dd832f8b4bd186c1075d12f3a41d92202c5d03cbe73</citedby><cites>FETCH-LOGICAL-c330t-e36cbd4b62569901fb5ab9dd832f8b4bd186c1075d12f3a41d92202c5d03cbe73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5277715$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1555425$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Garg, Meena</creatorcontrib><creatorcontrib>Kurzner, Sharon I.</creatorcontrib><creatorcontrib>Bautista, Daisy B.</creatorcontrib><creatorcontrib>Lew, Cheryl D.</creatorcontrib><creatorcontrib>Ramos, Angela D.</creatorcontrib><creatorcontrib>Platzker, Arnold C.G.</creatorcontrib><creatorcontrib>Keens, Thomas G.</creatorcontrib><title>Pulmonary Sequelae at Six Months following Extracorporeal Membrane Oxygenation</title><title>Chest</title><addtitle>Chest</addtitle><description>Mechanical assisted ventilation for neonatal respiratory failure is associated with residual lung disease. Because ECMO rests the lungs, it has been suggested that ECMO will prevent chronic lung disease in survivors. To determine whether or not ECMO survivors have evidence of pulmonary sequelae, we studied 19 infants who were treated with ECMO for neonatal respiratory failure. Ten infants still required supplemental oxygen or pulmonary medications or both to treat clinical lung disease during the first six months of life. Thoracic gas volume was normal. Pulmonary mechanics in ECMO survivors were compared with those of 13 preterm infants with BPD at similar age. We conclude that a significant proportion of ECMO survivors have residual abnormalities in pulmonary mechanics at 6 months of age. We speculate that neonatal lung injury due to meconium aspiration and other causes is a more important determinant of abnormal pulmonary sequelae than the method of treatment.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Bronchopulmonary Dysplasia - complications</subject><subject>Bronchopulmonary Dysplasia - therapy</subject><subject>Emergency and intensive care: neonates and children. Prematurity. Sudden death</subject><subject>Extracorporeal Membrane Oxygenation - adverse effects</subject><subject>Extracorporeal Membrane Oxygenation - methods</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Intensive care medicine</subject><subject>Lung Diseases - diagnosis</subject><subject>Lung Diseases - epidemiology</subject><subject>Lung Diseases - etiology</subject><subject>Meconium Aspiration Syndrome - complications</subject><subject>Meconium Aspiration Syndrome - therapy</subject><subject>Medical sciences</subject><subject>Persistent Fetal Circulation Syndrome - complications</subject><subject>Persistent Fetal Circulation Syndrome - therapy</subject><subject>Respiratory Distress Syndrome, Newborn - complications</subject><subject>Respiratory Distress Syndrome, Newborn - therapy</subject><subject>Respiratory Function Tests - methods</subject><subject>Respiratory Mechanics</subject><issn>0012-3692</issn><issn>1931-3543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UElP3DAUtlArGJY7F6Qcqt4y9RInMbcK0VKJTaI9W15eZoyceGonMPz7mmZU1AMXW0_v296H0CnBS8Ka9otZQxqXBJNlld-23kMLIhgpGa_YB7TAmNCS1YIeoMOUHnGeiaj30T7hnFeUL9Dt_eT7MKj4UjzA7wm8gkKNxYPbFjdhGNep6IL34dkNq-JyO0ZlQtyECMoXN9DrqAYo7rYvKxjU6MJwjD52yic42f1H6Ne3y58XV-X13fcfF1-vS8MYHktgtdG20jXltRCYdJorLaxtGe1aXWlL2toQ3HBLaMdURaygFFPDLWZGQ8OO0OdZdxNDTp1G2btkwPucJ0xJNrStGyFEBuIZaGJIKUInN9H1-VxJsHytUP6tME9EVvK1wkw522lPugf7Rpg7y_tPu71KRvkud2Bc-gfjtGkawt-c1261fnYRZOqV91mUzZ6PYYqD8v85n88UyNU9OYgyGQeDAZvpZpQ2uPdj_wHuFKAV</recordid><startdate>199204</startdate><enddate>199204</enddate><creator>Garg, Meena</creator><creator>Kurzner, Sharon I.</creator><creator>Bautista, Daisy B.</creator><creator>Lew, Cheryl D.</creator><creator>Ramos, Angela D.</creator><creator>Platzker, Arnold C.G.</creator><creator>Keens, Thomas G.</creator><general>Elsevier Inc</general><general>American College of Chest Physicians</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199204</creationdate><title>Pulmonary Sequelae at Six Months following Extracorporeal Membrane Oxygenation</title><author>Garg, Meena ; Kurzner, Sharon I. ; Bautista, Daisy B. ; Lew, Cheryl D. ; Ramos, Angela D. ; Platzker, Arnold C.G. ; Keens, Thomas G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c330t-e36cbd4b62569901fb5ab9dd832f8b4bd186c1075d12f3a41d92202c5d03cbe73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Bronchopulmonary Dysplasia - complications</topic><topic>Bronchopulmonary Dysplasia - therapy</topic><topic>Emergency and intensive care: neonates and children. Prematurity. Sudden death</topic><topic>Extracorporeal Membrane Oxygenation - adverse effects</topic><topic>Extracorporeal Membrane Oxygenation - methods</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Intensive care medicine</topic><topic>Lung Diseases - diagnosis</topic><topic>Lung Diseases - epidemiology</topic><topic>Lung Diseases - etiology</topic><topic>Meconium Aspiration Syndrome - complications</topic><topic>Meconium Aspiration Syndrome - therapy</topic><topic>Medical sciences</topic><topic>Persistent Fetal Circulation Syndrome - complications</topic><topic>Persistent Fetal Circulation Syndrome - therapy</topic><topic>Respiratory Distress Syndrome, Newborn - complications</topic><topic>Respiratory Distress Syndrome, Newborn - therapy</topic><topic>Respiratory Function Tests - methods</topic><topic>Respiratory Mechanics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Garg, Meena</creatorcontrib><creatorcontrib>Kurzner, Sharon I.</creatorcontrib><creatorcontrib>Bautista, Daisy B.</creatorcontrib><creatorcontrib>Lew, Cheryl D.</creatorcontrib><creatorcontrib>Ramos, Angela D.</creatorcontrib><creatorcontrib>Platzker, Arnold C.G.</creatorcontrib><creatorcontrib>Keens, Thomas G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chest</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Garg, Meena</au><au>Kurzner, Sharon I.</au><au>Bautista, Daisy B.</au><au>Lew, Cheryl D.</au><au>Ramos, Angela D.</au><au>Platzker, Arnold C.G.</au><au>Keens, Thomas G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pulmonary Sequelae at Six Months following Extracorporeal Membrane Oxygenation</atitle><jtitle>Chest</jtitle><addtitle>Chest</addtitle><date>1992-04</date><risdate>1992</risdate><volume>101</volume><issue>4</issue><spage>1086</spage><epage>1090</epage><pages>1086-1090</pages><issn>0012-3692</issn><eissn>1931-3543</eissn><coden>CHETBF</coden><abstract>Mechanical assisted ventilation for neonatal respiratory failure is associated with residual lung disease. Because ECMO rests the lungs, it has been suggested that ECMO will prevent chronic lung disease in survivors. To determine whether or not ECMO survivors have evidence of pulmonary sequelae, we studied 19 infants who were treated with ECMO for neonatal respiratory failure. Ten infants still required supplemental oxygen or pulmonary medications or both to treat clinical lung disease during the first six months of life. Thoracic gas volume was normal. Pulmonary mechanics in ECMO survivors were compared with those of 13 preterm infants with BPD at similar age. We conclude that a significant proportion of ECMO survivors have residual abnormalities in pulmonary mechanics at 6 months of age. We speculate that neonatal lung injury due to meconium aspiration and other causes is a more important determinant of abnormal pulmonary sequelae than the method of treatment.</abstract><cop>Northbrook, IL</cop><pub>Elsevier Inc</pub><pmid>1555425</pmid><doi>10.1378/chest.101.4.1086</doi><tpages>5</tpages></addata></record> |
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| subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Bronchopulmonary Dysplasia - complications Bronchopulmonary Dysplasia - therapy Emergency and intensive care: neonates and children. Prematurity. Sudden death Extracorporeal Membrane Oxygenation - adverse effects Extracorporeal Membrane Oxygenation - methods Follow-Up Studies Humans Infant Infant, Newborn Intensive care medicine Lung Diseases - diagnosis Lung Diseases - epidemiology Lung Diseases - etiology Meconium Aspiration Syndrome - complications Meconium Aspiration Syndrome - therapy Medical sciences Persistent Fetal Circulation Syndrome - complications Persistent Fetal Circulation Syndrome - therapy Respiratory Distress Syndrome, Newborn - complications Respiratory Distress Syndrome, Newborn - therapy Respiratory Function Tests - methods Respiratory Mechanics |
| title | Pulmonary Sequelae at Six Months following Extracorporeal Membrane Oxygenation |
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