44-HOMOOLIGOMYCINS A AND B, NEW ANTITUMOR ANTIBIOTICS FROM Streptomyces bottropensis: PRODUCING ORGANISM, FERMENTATION, ISOLATION, STRUCTURE ELUCIDATION AND BIOLOGICAL PROPERTIES
Oligomycin antibiotics, 44-homooligomycin A (NK86-0279 II) and B (NK86-0279 I) are newly discovered antitumor antibiotics with the substitution of ethyl for methyl at carbon 26. They were isolated from the culture broth of Streptomyces bottropensis NK86-0279. The structure of these two compounds was...
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| Veröffentlicht in: | Journal of antibiotics 1992/02/25, Vol.45(2), pp.171-179 |
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| container_title | Journal of antibiotics |
| container_volume | 45 |
| creator | YAMAZAKI, MASANORI YAMASHITA, TAKUMI HARADA, TAKASHI NISHIKIORI, TAKAAKI SAITO, SEIICHI SHIMADA, NOBUYOSHI FUJII, AKIO |
| description | Oligomycin antibiotics, 44-homooligomycin A (NK86-0279 II) and B (NK86-0279 I) are newly discovered antitumor antibiotics with the substitution of ethyl for methyl at carbon 26. They were isolated from the culture broth of Streptomyces bottropensis NK86-0279. The structure of these two compounds was deduced by spectroscopic and X-ray crystallographic analyses. These antibiotics showed potent antitumor activities against various tumor cells in vitro, and were active against Colon 26 carcinoma in vivo. Although they showed no activity at 1, 000 μg/ml against Gram-positive and Gram-negative bacteria and yeast, they have antifungal activity. |
| doi_str_mv | 10.7164/antibiotics.45.171 |
| format | Article |
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They were isolated from the culture broth of Streptomyces bottropensis NK86-0279. The structure of these two compounds was deduced by spectroscopic and X-ray crystallographic analyses. These antibiotics showed potent antitumor activities against various tumor cells in vitro, and were active against Colon 26 carcinoma in vivo. Although they showed no activity at 1, 000 μg/ml against Gram-positive and Gram-negative bacteria and yeast, they have antifungal activity.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.7164/antibiotics.45.171</identifier><identifier>PMID: 1556008</identifier><identifier>CODEN: JANTAJ</identifier><language>eng</language><publisher>Tokyo: JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</publisher><subject>Antibiotics, Antineoplastic - chemistry ; Antibiotics, Antineoplastic - isolation & purification ; Antineoplastic agents ; Biological and medical sciences ; Chemical Phenomena ; Chemistry, Physical ; General aspects ; Medical sciences ; Oligomycins - chemistry ; Oligomycins - isolation & purification ; Pharmacology. Drug treatments ; Streptomyces - classification ; Streptomyces - metabolism</subject><ispartof>The Journal of Antibiotics, 1992/02/25, Vol.45(2), pp.171-179</ispartof><rights>Japan Antibiotics Research Association</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4511-45670279b25bcdc9247c58f3f3eae3c28c7d88834f42e3c7f82fc840f73024063</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5319330$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1556008$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>YAMAZAKI, MASANORI</creatorcontrib><creatorcontrib>YAMASHITA, TAKUMI</creatorcontrib><creatorcontrib>HARADA, TAKASHI</creatorcontrib><creatorcontrib>NISHIKIORI, TAKAAKI</creatorcontrib><creatorcontrib>SAITO, SEIICHI</creatorcontrib><creatorcontrib>SHIMADA, NOBUYOSHI</creatorcontrib><creatorcontrib>FUJII, AKIO</creatorcontrib><title>44-HOMOOLIGOMYCINS A AND B, NEW ANTITUMOR ANTIBIOTICS FROM Streptomyces bottropensis: PRODUCING ORGANISM, FERMENTATION, ISOLATION, STRUCTURE ELUCIDATION AND BIOLOGICAL PROPERTIES</title><title>Journal of antibiotics</title><addtitle>J. Antibiot.</addtitle><description>Oligomycin antibiotics, 44-homooligomycin A (NK86-0279 II) and B (NK86-0279 I) are newly discovered antitumor antibiotics with the substitution of ethyl for methyl at carbon 26. They were isolated from the culture broth of Streptomyces bottropensis NK86-0279. The structure of these two compounds was deduced by spectroscopic and X-ray crystallographic analyses. These antibiotics showed potent antitumor activities against various tumor cells in vitro, and were active against Colon 26 carcinoma in vivo. Although they showed no activity at 1, 000 μg/ml against Gram-positive and Gram-negative bacteria and yeast, they have antifungal activity.</description><subject>Antibiotics, Antineoplastic - chemistry</subject><subject>Antibiotics, Antineoplastic - isolation & purification</subject><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Chemical Phenomena</subject><subject>Chemistry, Physical</subject><subject>General aspects</subject><subject>Medical sciences</subject><subject>Oligomycins - chemistry</subject><subject>Oligomycins - isolation & purification</subject><subject>Pharmacology. 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Antibiot.</addtitle><date>1992</date><risdate>1992</risdate><volume>45</volume><issue>2</issue><spage>171</spage><epage>179</epage><pages>171-179</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><coden>JANTAJ</coden><abstract>Oligomycin antibiotics, 44-homooligomycin A (NK86-0279 II) and B (NK86-0279 I) are newly discovered antitumor antibiotics with the substitution of ethyl for methyl at carbon 26. They were isolated from the culture broth of Streptomyces bottropensis NK86-0279. The structure of these two compounds was deduced by spectroscopic and X-ray crystallographic analyses. These antibiotics showed potent antitumor activities against various tumor cells in vitro, and were active against Colon 26 carcinoma in vivo. 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| fulltext | fulltext |
| identifier | ISSN: 0021-8820 |
| ispartof | The Journal of Antibiotics, 1992/02/25, Vol.45(2), pp.171-179 |
| issn | 0021-8820 1881-1469 |
| language | eng |
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| source | J-STAGE Free; MEDLINE |
| subjects | Antibiotics, Antineoplastic - chemistry Antibiotics, Antineoplastic - isolation & purification Antineoplastic agents Biological and medical sciences Chemical Phenomena Chemistry, Physical General aspects Medical sciences Oligomycins - chemistry Oligomycins - isolation & purification Pharmacology. Drug treatments Streptomyces - classification Streptomyces - metabolism |
| title | 44-HOMOOLIGOMYCINS A AND B, NEW ANTITUMOR ANTIBIOTICS FROM Streptomyces bottropensis: PRODUCING ORGANISM, FERMENTATION, ISOLATION, STRUCTURE ELUCIDATION AND BIOLOGICAL PROPERTIES |
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