Recombinant tissue-type plasminogen activator is superior to streptokinase for local intra-arterial thrombolysis
The results of local intra‐arterial thrombolysis in 98 patients treated with streptokinase and 69 patients treated with recombinant tissue plasminogen activator (rtPA) have been compared. The two groups of patients were well matched and their treatment protocols were identical except with regard to...
Gespeichert in:
| Veröffentlicht in: | British journal of surgery 1992-03, Vol.79 (3), p.272-275 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 275 |
|---|---|
| container_issue | 3 |
| container_start_page | 272 |
| container_title | British journal of surgery |
| container_volume | 79 |
| creator | Lonsdale, R. J. Berridge, D. C. Earnshaw, J. J. Harrison, J. D. Gregson, R. H. S. Wenham, P. W. Hopkinson, B. R. Makin, G. S. |
| description | The results of local intra‐arterial thrombolysis in 98 patients treated with streptokinase and 69 patients treated with recombinant tissue plasminogen activator (rtPA) have been compared. The two groups of patients were well matched and their treatment protocols were identical except with regard to the thrombolytic agent used. Strict criteria for defining successful thrombolysis were used. Successful lysis was achieved in 40 of 98 patients (41 per cent) receiving streptokinase and 40 of 69 patients (58 per cent) receiving rtPA (P < 0.05). The time to lysis was significantly shorter with rtPA, median time 22h, than with streptokinase, median time 40 h ( P < 0.002). There was no diference in the incidence of haemorrhagic complications. These results suggest that rtPA is superior to streptokinase for local intra‐arterial thrombolysis. |
| doi_str_mv | 10.1002/bjs.1800790330 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_72867818</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>72867818</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3070-13655d0653e41a7e6d60397e3d0ac05f934c1247d437a6e73b3eed861e14edd33</originalsourceid><addsrcrecordid>eNpFkU1v1DAQhi0EKkvhyg0pB8QtZZyJ7eRIK9gCVZH4ENwsbzILbpM4eBxg_z2udtU9zdfzjjV-hXgu4UwCVK83N3wmGwDTAiI8ECuJWpWV1M1DsYLcLyVW-Fg8Yb4BkAiqOhEnUiklQa7E_Jm6MG785KZUJM-8UJl2MxXz4Hj0U_hJU-G65P-4FGLhueBlpuhznkLBKdKcwm2WMxXb3BxC54bCTym60sWUyVymXzG_EYYde34qHm3dwPTsEE_Ft3dvv15cllef1u8v3lyVHYKB8u4K1YNWSLV0hnSvAVtD2IPrQG1brDtZ1aav0ThNBjdI1Ddakqyp7xFPxav93jmG3wtxsqPnjobBTRQWtqZqtGlkk8EXB3DZjNTbOfrRxZ09fFGevzzMHefbttFNned7TFUSNLYZa_fYXz_Q7rgF7J1NNttkjzbZ8w9fjlXWlnut50T_7rUu3lpt0Cj7_XptL3_o8_V19dFK_A-cdZci</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72867818</pqid></control><display><type>article</type><title>Recombinant tissue-type plasminogen activator is superior to streptokinase for local intra-arterial thrombolysis</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Lonsdale, R. J. ; Berridge, D. C. ; Earnshaw, J. J. ; Harrison, J. D. ; Gregson, R. H. S. ; Wenham, P. W. ; Hopkinson, B. R. ; Makin, G. S.</creator><creatorcontrib>Lonsdale, R. J. ; Berridge, D. C. ; Earnshaw, J. J. ; Harrison, J. D. ; Gregson, R. H. S. ; Wenham, P. W. ; Hopkinson, B. R. ; Makin, G. S.</creatorcontrib><description>The results of local intra‐arterial thrombolysis in 98 patients treated with streptokinase and 69 patients treated with recombinant tissue plasminogen activator (rtPA) have been compared. The two groups of patients were well matched and their treatment protocols were identical except with regard to the thrombolytic agent used. Strict criteria for defining successful thrombolysis were used. Successful lysis was achieved in 40 of 98 patients (41 per cent) receiving streptokinase and 40 of 69 patients (58 per cent) receiving rtPA (P < 0.05). The time to lysis was significantly shorter with rtPA, median time 22h, than with streptokinase, median time 40 h ( P < 0.002). There was no diference in the incidence of haemorrhagic complications. These results suggest that rtPA is superior to streptokinase for local intra‐arterial thrombolysis.</description><identifier>ISSN: 0007-1323</identifier><identifier>EISSN: 1365-2168</identifier><identifier>DOI: 10.1002/bjs.1800790330</identifier><identifier>PMID: 1555101</identifier><identifier>CODEN: BJSUAM</identifier><language>eng</language><publisher>Bristol: John Wiley & Sons, Ltd</publisher><subject>Adult ; Aged ; Arterial Occlusive Diseases - drug therapy ; Biological and medical sciences ; Blood. Blood coagulation. Reticuloendothelial system ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Prospective Studies ; Recombinant Proteins - therapeutic use ; Streptokinase - therapeutic use ; Thrombolytic Therapy ; Time Factors ; Tissue Plasminogen Activator - therapeutic use ; Treatment Outcome</subject><ispartof>British journal of surgery, 1992-03, Vol.79 (3), p.272-275</ispartof><rights>Copyright © 1992 British Journal of Surgery Society Ltd.</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3070-13655d0653e41a7e6d60397e3d0ac05f934c1247d437a6e73b3eed861e14edd33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fbjs.1800790330$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fbjs.1800790330$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5210639$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1555101$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lonsdale, R. J.</creatorcontrib><creatorcontrib>Berridge, D. C.</creatorcontrib><creatorcontrib>Earnshaw, J. J.</creatorcontrib><creatorcontrib>Harrison, J. D.</creatorcontrib><creatorcontrib>Gregson, R. H. S.</creatorcontrib><creatorcontrib>Wenham, P. W.</creatorcontrib><creatorcontrib>Hopkinson, B. R.</creatorcontrib><creatorcontrib>Makin, G. S.</creatorcontrib><title>Recombinant tissue-type plasminogen activator is superior to streptokinase for local intra-arterial thrombolysis</title><title>British journal of surgery</title><addtitle>Br J Surg</addtitle><description>The results of local intra‐arterial thrombolysis in 98 patients treated with streptokinase and 69 patients treated with recombinant tissue plasminogen activator (rtPA) have been compared. The two groups of patients were well matched and their treatment protocols were identical except with regard to the thrombolytic agent used. Strict criteria for defining successful thrombolysis were used. Successful lysis was achieved in 40 of 98 patients (41 per cent) receiving streptokinase and 40 of 69 patients (58 per cent) receiving rtPA (P < 0.05). The time to lysis was significantly shorter with rtPA, median time 22h, than with streptokinase, median time 40 h ( P < 0.002). There was no diference in the incidence of haemorrhagic complications. These results suggest that rtPA is superior to streptokinase for local intra‐arterial thrombolysis.</description><subject>Adult</subject><subject>Aged</subject><subject>Arterial Occlusive Diseases - drug therapy</subject><subject>Biological and medical sciences</subject><subject>Blood. Blood coagulation. Reticuloendothelial system</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Prospective Studies</subject><subject>Recombinant Proteins - therapeutic use</subject><subject>Streptokinase - therapeutic use</subject><subject>Thrombolytic Therapy</subject><subject>Time Factors</subject><subject>Tissue Plasminogen Activator - therapeutic use</subject><subject>Treatment Outcome</subject><issn>0007-1323</issn><issn>1365-2168</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkU1v1DAQhi0EKkvhyg0pB8QtZZyJ7eRIK9gCVZH4ENwsbzILbpM4eBxg_z2udtU9zdfzjjV-hXgu4UwCVK83N3wmGwDTAiI8ECuJWpWV1M1DsYLcLyVW-Fg8Yb4BkAiqOhEnUiklQa7E_Jm6MG785KZUJM-8UJl2MxXz4Hj0U_hJU-G65P-4FGLhueBlpuhznkLBKdKcwm2WMxXb3BxC54bCTym60sWUyVymXzG_EYYde34qHm3dwPTsEE_Ft3dvv15cllef1u8v3lyVHYKB8u4K1YNWSLV0hnSvAVtD2IPrQG1brDtZ1aav0ThNBjdI1Ddakqyp7xFPxav93jmG3wtxsqPnjobBTRQWtqZqtGlkk8EXB3DZjNTbOfrRxZ09fFGevzzMHefbttFNned7TFUSNLYZa_fYXz_Q7rgF7J1NNttkjzbZ8w9fjlXWlnut50T_7rUu3lpt0Cj7_XptL3_o8_V19dFK_A-cdZci</recordid><startdate>199203</startdate><enddate>199203</enddate><creator>Lonsdale, R. J.</creator><creator>Berridge, D. C.</creator><creator>Earnshaw, J. J.</creator><creator>Harrison, J. D.</creator><creator>Gregson, R. H. S.</creator><creator>Wenham, P. W.</creator><creator>Hopkinson, B. R.</creator><creator>Makin, G. S.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>199203</creationdate><title>Recombinant tissue-type plasminogen activator is superior to streptokinase for local intra-arterial thrombolysis</title><author>Lonsdale, R. J. ; Berridge, D. C. ; Earnshaw, J. J. ; Harrison, J. D. ; Gregson, R. H. S. ; Wenham, P. W. ; Hopkinson, B. R. ; Makin, G. S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3070-13655d0653e41a7e6d60397e3d0ac05f934c1247d437a6e73b3eed861e14edd33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Arterial Occlusive Diseases - drug therapy</topic><topic>Biological and medical sciences</topic><topic>Blood. Blood coagulation. Reticuloendothelial system</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Prospective Studies</topic><topic>Recombinant Proteins - therapeutic use</topic><topic>Streptokinase - therapeutic use</topic><topic>Thrombolytic Therapy</topic><topic>Time Factors</topic><topic>Tissue Plasminogen Activator - therapeutic use</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lonsdale, R. J.</creatorcontrib><creatorcontrib>Berridge, D. C.</creatorcontrib><creatorcontrib>Earnshaw, J. J.</creatorcontrib><creatorcontrib>Harrison, J. D.</creatorcontrib><creatorcontrib>Gregson, R. H. S.</creatorcontrib><creatorcontrib>Wenham, P. W.</creatorcontrib><creatorcontrib>Hopkinson, B. R.</creatorcontrib><creatorcontrib>Makin, G. S.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lonsdale, R. J.</au><au>Berridge, D. C.</au><au>Earnshaw, J. J.</au><au>Harrison, J. D.</au><au>Gregson, R. H. S.</au><au>Wenham, P. W.</au><au>Hopkinson, B. R.</au><au>Makin, G. S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recombinant tissue-type plasminogen activator is superior to streptokinase for local intra-arterial thrombolysis</atitle><jtitle>British journal of surgery</jtitle><addtitle>Br J Surg</addtitle><date>1992-03</date><risdate>1992</risdate><volume>79</volume><issue>3</issue><spage>272</spage><epage>275</epage><pages>272-275</pages><issn>0007-1323</issn><eissn>1365-2168</eissn><coden>BJSUAM</coden><abstract>The results of local intra‐arterial thrombolysis in 98 patients treated with streptokinase and 69 patients treated with recombinant tissue plasminogen activator (rtPA) have been compared. The two groups of patients were well matched and their treatment protocols were identical except with regard to the thrombolytic agent used. Strict criteria for defining successful thrombolysis were used. Successful lysis was achieved in 40 of 98 patients (41 per cent) receiving streptokinase and 40 of 69 patients (58 per cent) receiving rtPA (P < 0.05). The time to lysis was significantly shorter with rtPA, median time 22h, than with streptokinase, median time 40 h ( P < 0.002). There was no diference in the incidence of haemorrhagic complications. These results suggest that rtPA is superior to streptokinase for local intra‐arterial thrombolysis.</abstract><cop>Bristol</cop><pub>John Wiley & Sons, Ltd</pub><pmid>1555101</pmid><doi>10.1002/bjs.1800790330</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-1323 |
| ispartof | British journal of surgery, 1992-03, Vol.79 (3), p.272-275 |
| issn | 0007-1323 1365-2168 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72867818 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Aged Arterial Occlusive Diseases - drug therapy Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system Female Humans Male Medical sciences Middle Aged Pharmacology. Drug treatments Prospective Studies Recombinant Proteins - therapeutic use Streptokinase - therapeutic use Thrombolytic Therapy Time Factors Tissue Plasminogen Activator - therapeutic use Treatment Outcome |
| title | Recombinant tissue-type plasminogen activator is superior to streptokinase for local intra-arterial thrombolysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T10%3A50%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Recombinant%20tissue-type%20plasminogen%20activator%20is%20superior%20to%20streptokinase%20for%20local%20intra-arterial%20thrombolysis&rft.jtitle=British%20journal%20of%20surgery&rft.au=Lonsdale,%20R.%20J.&rft.date=1992-03&rft.volume=79&rft.issue=3&rft.spage=272&rft.epage=275&rft.pages=272-275&rft.issn=0007-1323&rft.eissn=1365-2168&rft.coden=BJSUAM&rft_id=info:doi/10.1002/bjs.1800790330&rft_dat=%3Cproquest_pubme%3E72867818%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=72867818&rft_id=info:pmid/1555101&rfr_iscdi=true |