Chest wall kinematics during chemically stimulated breathing in healthy man
Chest wall compartment kinematics and respiratory muscle coordinate activity, during either hypercapnia or hypoxia, have not been comparatively assessed in healthy humans. We assessed the displacement volume of the chest wall (Vcw) in 5 normal subjects during hypoxic-normocapnic and hypercapnic-hype...
Gespeichert in:
Veröffentlicht in: | Lung 2002, Vol.180 (6), p.349-357 |
---|---|
Hauptverfasser: | , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 357 |
---|---|
container_issue | 6 |
container_start_page | 349 |
container_title | Lung |
container_volume | 180 |
creator | Filippelli, M Romagnoli, I Gigliotti, F Lanini, B Nerini, M Stendardi, L Bianchi, R Duranti, R Scano, G |
description | Chest wall compartment kinematics and respiratory muscle coordinate activity, during either hypercapnia or hypoxia, have not been comparatively assessed in healthy humans. We assessed the displacement volume of the chest wall (Vcw) in 5 normal subjects during hypoxic-normocapnic and hypercapnic-hyperoxic rebreathing by using linearized magnetometers. Vcw was divided into displacement volumes of the rib cage (Vrc) and the abdomen (Vab). Esophageal (Pes) and gastric (Pga) pressures were simultaneously recorded and transdiaphragmatic pressure (Pdi) was calculated by subtracting Pes from Pga. Pressure swings (sw) from end expiration (EE) to end inspiration (EI) were also calculated. During both hypoxia and hypercapnia, from quiet breathing to 40 L/min VE, Vrc,EI increased consistently but Vrc,EE, and Vab,EI did not. Moreover, Vab,EE decreased significantly during hypercapnia and remained unchanged during hypoxia. PesEI decreased (more negative values) and PesEE increased (less negative values) during either stimulus, while PgaEE increased with hypercapnia. Pdisw, calculated as the difference between PdiEE and PdiEI, increased significantly with both hypercapnia and hypoxia ( p = 0.002 for both). On the plot of Pes vs Pga, the slope of a line from end expiratory to end inspiratory lung volume between 20 and 40 L/min VE progressively increased during hypercapnia indicating increasing rib cage muscle (RCM) contribution to inspiratory pressure swings relative to the diaphragm. From these results we conclude that in healthy man: (i) with both chemical stimuli RCM contribution accounts for increase in Vrc displacement; (ii) with hypercapnia, the decrease in Vab,EE displacement indicates abdominal muscle (ABM) contribution to tidal volume; (iii) RCM and ABM assist the diaphragmatic function during hypercapnic stimulation. |
doi_str_mv | 10.1007/s00408-002-0108-5 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72866613</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>692107651</sourcerecordid><originalsourceid>FETCH-LOGICAL-c324t-11e8f613ecf781bb143d16170d5c69da6ab4b06e2f45d9e0a97309ccd9e1d983</originalsourceid><addsrcrecordid>eNpdkE1LxDAQhoMo7rr6A7xI8eCtOpO0SXuUxS9c8LL3kCapzdqPNWmR_fdm2QXB0wzMMy8vDyHXCPcIIB4CQAZFCkBTwLjkJ2SOGaMpihxOyRxYhimNzIxchLABQMExPyczpDwTlPE5eV82NozJj2rb5Mv1tlOj0yExk3f9Z6Ib2zkdb7skjK6bWjVak1TeqrHZ312fNFa1Y7NLOtVfkrNatcFeHeeCrJ-f1svXdPXx8rZ8XKWa0WxMEW1Rc2RW16LAqoqNDXIUYHLNS6O4qrIKuKV1lpvSgioFg1LruKMpC7Ygd4fYrR--p9hedi5o27aqt8MUpKAF5zE_grf_wM0w-T5Wk5ShYIyVPEJ4gLQfQvC2llvvOuV3EkHuLcuDZRkty71lmcefm2PwVHXW_H0ctbJfcqJ3ig</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>231733396</pqid></control><display><type>article</type><title>Chest wall kinematics during chemically stimulated breathing in healthy man</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Filippelli, M ; Romagnoli, I ; Gigliotti, F ; Lanini, B ; Nerini, M ; Stendardi, L ; Bianchi, R ; Duranti, R ; Scano, G</creator><creatorcontrib>Filippelli, M ; Romagnoli, I ; Gigliotti, F ; Lanini, B ; Nerini, M ; Stendardi, L ; Bianchi, R ; Duranti, R ; Scano, G</creatorcontrib><description>Chest wall compartment kinematics and respiratory muscle coordinate activity, during either hypercapnia or hypoxia, have not been comparatively assessed in healthy humans. We assessed the displacement volume of the chest wall (Vcw) in 5 normal subjects during hypoxic-normocapnic and hypercapnic-hyperoxic rebreathing by using linearized magnetometers. Vcw was divided into displacement volumes of the rib cage (Vrc) and the abdomen (Vab). Esophageal (Pes) and gastric (Pga) pressures were simultaneously recorded and transdiaphragmatic pressure (Pdi) was calculated by subtracting Pes from Pga. Pressure swings (sw) from end expiration (EE) to end inspiration (EI) were also calculated. During both hypoxia and hypercapnia, from quiet breathing to 40 L/min VE, Vrc,EI increased consistently but Vrc,EE, and Vab,EI did not. Moreover, Vab,EE decreased significantly during hypercapnia and remained unchanged during hypoxia. PesEI decreased (more negative values) and PesEE increased (less negative values) during either stimulus, while PgaEE increased with hypercapnia. Pdisw, calculated as the difference between PdiEE and PdiEI, increased significantly with both hypercapnia and hypoxia ( p = 0.002 for both). On the plot of Pes vs Pga, the slope of a line from end expiratory to end inspiratory lung volume between 20 and 40 L/min VE progressively increased during hypercapnia indicating increasing rib cage muscle (RCM) contribution to inspiratory pressure swings relative to the diaphragm. From these results we conclude that in healthy man: (i) with both chemical stimuli RCM contribution accounts for increase in Vrc displacement; (ii) with hypercapnia, the decrease in Vab,EE displacement indicates abdominal muscle (ABM) contribution to tidal volume; (iii) RCM and ABM assist the diaphragmatic function during hypercapnic stimulation.</description><identifier>ISSN: 0341-2040</identifier><identifier>EISSN: 1432-1750</identifier><identifier>DOI: 10.1007/s00408-002-0108-5</identifier><identifier>PMID: 12647236</identifier><identifier>CODEN: LUNGD9</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Adult ; Biomechanical Phenomena ; Humans ; Hypercapnia - physiopathology ; Hypoxia - physiopathology ; Male ; Respiratory Mechanics ; Respiratory Muscles - physiology</subject><ispartof>Lung, 2002, Vol.180 (6), p.349-357</ispartof><rights>Copyright Springer-Verlag New York, Inc. 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c324t-11e8f613ecf781bb143d16170d5c69da6ab4b06e2f45d9e0a97309ccd9e1d983</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12647236$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Filippelli, M</creatorcontrib><creatorcontrib>Romagnoli, I</creatorcontrib><creatorcontrib>Gigliotti, F</creatorcontrib><creatorcontrib>Lanini, B</creatorcontrib><creatorcontrib>Nerini, M</creatorcontrib><creatorcontrib>Stendardi, L</creatorcontrib><creatorcontrib>Bianchi, R</creatorcontrib><creatorcontrib>Duranti, R</creatorcontrib><creatorcontrib>Scano, G</creatorcontrib><title>Chest wall kinematics during chemically stimulated breathing in healthy man</title><title>Lung</title><addtitle>Lung</addtitle><description>Chest wall compartment kinematics and respiratory muscle coordinate activity, during either hypercapnia or hypoxia, have not been comparatively assessed in healthy humans. We assessed the displacement volume of the chest wall (Vcw) in 5 normal subjects during hypoxic-normocapnic and hypercapnic-hyperoxic rebreathing by using linearized magnetometers. Vcw was divided into displacement volumes of the rib cage (Vrc) and the abdomen (Vab). Esophageal (Pes) and gastric (Pga) pressures were simultaneously recorded and transdiaphragmatic pressure (Pdi) was calculated by subtracting Pes from Pga. Pressure swings (sw) from end expiration (EE) to end inspiration (EI) were also calculated. During both hypoxia and hypercapnia, from quiet breathing to 40 L/min VE, Vrc,EI increased consistently but Vrc,EE, and Vab,EI did not. Moreover, Vab,EE decreased significantly during hypercapnia and remained unchanged during hypoxia. PesEI decreased (more negative values) and PesEE increased (less negative values) during either stimulus, while PgaEE increased with hypercapnia. Pdisw, calculated as the difference between PdiEE and PdiEI, increased significantly with both hypercapnia and hypoxia ( p = 0.002 for both). On the plot of Pes vs Pga, the slope of a line from end expiratory to end inspiratory lung volume between 20 and 40 L/min VE progressively increased during hypercapnia indicating increasing rib cage muscle (RCM) contribution to inspiratory pressure swings relative to the diaphragm. From these results we conclude that in healthy man: (i) with both chemical stimuli RCM contribution accounts for increase in Vrc displacement; (ii) with hypercapnia, the decrease in Vab,EE displacement indicates abdominal muscle (ABM) contribution to tidal volume; (iii) RCM and ABM assist the diaphragmatic function during hypercapnic stimulation.</description><subject>Adult</subject><subject>Biomechanical Phenomena</subject><subject>Humans</subject><subject>Hypercapnia - physiopathology</subject><subject>Hypoxia - physiopathology</subject><subject>Male</subject><subject>Respiratory Mechanics</subject><subject>Respiratory Muscles - physiology</subject><issn>0341-2040</issn><issn>1432-1750</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkE1LxDAQhoMo7rr6A7xI8eCtOpO0SXuUxS9c8LL3kCapzdqPNWmR_fdm2QXB0wzMMy8vDyHXCPcIIB4CQAZFCkBTwLjkJ2SOGaMpihxOyRxYhimNzIxchLABQMExPyczpDwTlPE5eV82NozJj2rb5Mv1tlOj0yExk3f9Z6Ib2zkdb7skjK6bWjVak1TeqrHZ312fNFa1Y7NLOtVfkrNatcFeHeeCrJ-f1svXdPXx8rZ8XKWa0WxMEW1Rc2RW16LAqoqNDXIUYHLNS6O4qrIKuKV1lpvSgioFg1LruKMpC7Ygd4fYrR--p9hedi5o27aqt8MUpKAF5zE_grf_wM0w-T5Wk5ShYIyVPEJ4gLQfQvC2llvvOuV3EkHuLcuDZRkty71lmcefm2PwVHXW_H0ctbJfcqJ3ig</recordid><startdate>2002</startdate><enddate>2002</enddate><creator>Filippelli, M</creator><creator>Romagnoli, I</creator><creator>Gigliotti, F</creator><creator>Lanini, B</creator><creator>Nerini, M</creator><creator>Stendardi, L</creator><creator>Bianchi, R</creator><creator>Duranti, R</creator><creator>Scano, G</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>2002</creationdate><title>Chest wall kinematics during chemically stimulated breathing in healthy man</title><author>Filippelli, M ; Romagnoli, I ; Gigliotti, F ; Lanini, B ; Nerini, M ; Stendardi, L ; Bianchi, R ; Duranti, R ; Scano, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c324t-11e8f613ecf781bb143d16170d5c69da6ab4b06e2f45d9e0a97309ccd9e1d983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Biomechanical Phenomena</topic><topic>Humans</topic><topic>Hypercapnia - physiopathology</topic><topic>Hypoxia - physiopathology</topic><topic>Male</topic><topic>Respiratory Mechanics</topic><topic>Respiratory Muscles - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Filippelli, M</creatorcontrib><creatorcontrib>Romagnoli, I</creatorcontrib><creatorcontrib>Gigliotti, F</creatorcontrib><creatorcontrib>Lanini, B</creatorcontrib><creatorcontrib>Nerini, M</creatorcontrib><creatorcontrib>Stendardi, L</creatorcontrib><creatorcontrib>Bianchi, R</creatorcontrib><creatorcontrib>Duranti, R</creatorcontrib><creatorcontrib>Scano, G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Proquest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Lung</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Filippelli, M</au><au>Romagnoli, I</au><au>Gigliotti, F</au><au>Lanini, B</au><au>Nerini, M</au><au>Stendardi, L</au><au>Bianchi, R</au><au>Duranti, R</au><au>Scano, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chest wall kinematics during chemically stimulated breathing in healthy man</atitle><jtitle>Lung</jtitle><addtitle>Lung</addtitle><date>2002</date><risdate>2002</risdate><volume>180</volume><issue>6</issue><spage>349</spage><epage>357</epage><pages>349-357</pages><issn>0341-2040</issn><eissn>1432-1750</eissn><coden>LUNGD9</coden><abstract>Chest wall compartment kinematics and respiratory muscle coordinate activity, during either hypercapnia or hypoxia, have not been comparatively assessed in healthy humans. We assessed the displacement volume of the chest wall (Vcw) in 5 normal subjects during hypoxic-normocapnic and hypercapnic-hyperoxic rebreathing by using linearized magnetometers. Vcw was divided into displacement volumes of the rib cage (Vrc) and the abdomen (Vab). Esophageal (Pes) and gastric (Pga) pressures were simultaneously recorded and transdiaphragmatic pressure (Pdi) was calculated by subtracting Pes from Pga. Pressure swings (sw) from end expiration (EE) to end inspiration (EI) were also calculated. During both hypoxia and hypercapnia, from quiet breathing to 40 L/min VE, Vrc,EI increased consistently but Vrc,EE, and Vab,EI did not. Moreover, Vab,EE decreased significantly during hypercapnia and remained unchanged during hypoxia. PesEI decreased (more negative values) and PesEE increased (less negative values) during either stimulus, while PgaEE increased with hypercapnia. Pdisw, calculated as the difference between PdiEE and PdiEI, increased significantly with both hypercapnia and hypoxia ( p = 0.002 for both). On the plot of Pes vs Pga, the slope of a line from end expiratory to end inspiratory lung volume between 20 and 40 L/min VE progressively increased during hypercapnia indicating increasing rib cage muscle (RCM) contribution to inspiratory pressure swings relative to the diaphragm. From these results we conclude that in healthy man: (i) with both chemical stimuli RCM contribution accounts for increase in Vrc displacement; (ii) with hypercapnia, the decrease in Vab,EE displacement indicates abdominal muscle (ABM) contribution to tidal volume; (iii) RCM and ABM assist the diaphragmatic function during hypercapnic stimulation.</abstract><cop>United States</cop><pub>Springer Nature B.V</pub><pmid>12647236</pmid><doi>10.1007/s00408-002-0108-5</doi><tpages>9</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0341-2040 |
ispartof | Lung, 2002, Vol.180 (6), p.349-357 |
issn | 0341-2040 1432-1750 |
language | eng |
recordid | cdi_proquest_miscellaneous_72866613 |
source | MEDLINE; SpringerLink Journals - AutoHoldings |
subjects | Adult Biomechanical Phenomena Humans Hypercapnia - physiopathology Hypoxia - physiopathology Male Respiratory Mechanics Respiratory Muscles - physiology |
title | Chest wall kinematics during chemically stimulated breathing in healthy man |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T17%3A48%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Chest%20wall%20kinematics%20during%20chemically%20stimulated%20breathing%20in%20healthy%20man&rft.jtitle=Lung&rft.au=Filippelli,%20M&rft.date=2002&rft.volume=180&rft.issue=6&rft.spage=349&rft.epage=357&rft.pages=349-357&rft.issn=0341-2040&rft.eissn=1432-1750&rft.coden=LUNGD9&rft_id=info:doi/10.1007/s00408-002-0108-5&rft_dat=%3Cproquest_cross%3E692107651%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=231733396&rft_id=info:pmid/12647236&rfr_iscdi=true |