Cell cycle-associated expression of M2-type isozyme of pyruvate kinase in proliferating rat thymocytes

During a complete cell cycle of rat thymocytes stimulated by concanavalin A and interleukin 2, the activity and mRNA level of pyruvate kinase reached a maximum (8-12-fold increase) 48 h after stimulation coinciding with the S-phase of the cell cycle. Increases of cellular enzyme activity, pyruvate k...

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Veröffentlicht in:	The Journal of biological chemistry 1992-03, Vol.267 (9), p.6421-6424
Hauptverfasser:	NETZKER, R, GREINER, E, EIGENBRODT, E, NOGUCHI, T, TANAKA, T, BRAND, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Cell Cycle - physiology Cell Division Cells, Cultured Concanavalin A - pharmacology Eflornithine - pharmacology Enzymes and enzyme inhibitors Female Fundamental and applied biological sciences. Psychology Immunoblotting Isoenzymes - biosynthesis Isoenzymes - genetics Isoenzymes - metabolism Kinetics Lymphocyte Activation Pyruvate Kinase - biosynthesis Pyruvate Kinase - genetics Pyruvate Kinase - metabolism Rats Rats, Inbred Strains RNA, Messenger - drug effects RNA, Messenger - metabolism T-Lymphocytes - cytology T-Lymphocytes - drug effects T-Lymphocytes - enzymology Thymus Gland - enzymology Transferases
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