Production of cytokines in sarcoid lymph nodes: Preferential expression of interleukin-1β and interferon-γ genes

Sarcoidosis is a chronic granulomatous disease that may be considered to be a human model for the delayed-type hypersensitivity reaction. The expression of cytokine genes in organs displaying sarcoid granulomas was analyzed by in situ hybridization with several cytokine probes using biopsies from 11...

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Veröffentlicht in:	Human pathology 1992-03, Vol.23 (3), p.317-323
Hauptverfasser:	Devergne, O., Emilie, D., Peuchmaur, M., Crevon, M.C., D'Agay, M.F., Galanaud, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences cytokine Cytokines - biosynthesis Cytokines - genetics delayed type hypersensitivity reaction Gene Expression Humans in situ hybridization Interferon-gamma - biosynthesis Interferon-gamma - genetics Interleukin-1 - biosynthesis Interleukin-1 - genetics lymph node Lymphatic Diseases - genetics Lymphatic Diseases - metabolism Medical sciences Nucleic Acid Hybridization RNA, Messenger - analysis sarcoidosis Sarcoidosis - genetics Sarcoidosis - metabolism Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
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