Effects of alkylating metabolites of ifosfamide and its bromo analogues on DNA of HeLa cells

The in vitro cytotoxicity and mechanism of action of three alkylating compounds: an active metabolite of ifosfamide ( 1, isophosphoramide mustard, N, N'-bis(2-chloroethyl)phosphorodiamidic acid) and its bromo substituted analogues, 2 (one chlorine atom replaced by bromine atom) and 3 (two chlor...

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Veröffentlicht in:	Biochemical pharmacology 1992-03, Vol.43 (5), p.937-943
Hauptverfasser:	Studzian, Kazimierz, Kinas, Ryszard, Ciesielska, Ewa, Szmigiero, Leszek
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences Cell Division - drug effects Cell Survival - drug effects Cross-Linking Reagents DNA, Neoplasm - drug effects Dose-Response Relationship, Drug General aspects HeLa Cells - drug effects Humans Ifosfamide - analogs & derivatives Ifosfamide - pharmacology Medical sciences Pharmacology. Drug treatments Phosphoramide Mustards - pharmacology
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