Pregnancy in sickle cell disease in Bahrain
ABSTRACT Objective To review the maternal and fetal complications in pregnant women with sickle cell disease and to compare their pregnancy outcome with those of controls. Design A case‐control study. Setting Ministry of Health hospitals in Bahrain. Subjects 147 pregnancies in 140 women with sickle...
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| Veröffentlicht in: | BJOG : an international journal of obstetrics and gynaecology 1992-02, Vol.99 (2), p.101-104 |
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| container_title | BJOG : an international journal of obstetrics and gynaecology |
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| creator | EL‐SHAFEI, AFFAF M. DHALIWAL, JAGJEEVAN KAUR SANDHU, AMARJEET KAUR |
| description | ABSTRACT
Objective
To review the maternal and fetal complications in pregnant women with sickle cell disease and to compare their pregnancy outcome with those of controls.
Design
A case‐control study.
Setting
Ministry of Health hospitals in Bahrain.
Subjects
147 pregnancies in 140 women with sickle cell disease and 294 controls matched for age and parity
Main outcome measures
The characteristics of women who had crises, the frequency of the crises, hypertensive disorders of pregnancy, infection, diabetes, perinatal mortality and the delivery statisties in the index and control women.
Results
Maternal mortality was 1.4% and perinatal mortality was 73.3/1000 total births in women with sickle cell disease, there were no maternal deaths and the perinatal mortality was 6.8/1000 births in the control group. Anaemia was treated by blood transfusion in 47% of women with sickle cell disease and, of these, 39% had a crisis that appeared to have been precipitated by the transfusion in the absence of any other predisposing factors. The presence of raised HbF did not decrease the number of crises but reduced their severity.
Conclusion
Pregnancy in women with sickle cell disease should be monitored very closely as it constitutes a high risk to both the mother and the baby. |
| doi_str_mv | 10.1111/j.1471-0528.1992.tb14463.x |
| format | Article |
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Objective
To review the maternal and fetal complications in pregnant women with sickle cell disease and to compare their pregnancy outcome with those of controls.
Design
A case‐control study.
Setting
Ministry of Health hospitals in Bahrain.
Subjects
147 pregnancies in 140 women with sickle cell disease and 294 controls matched for age and parity
Main outcome measures
The characteristics of women who had crises, the frequency of the crises, hypertensive disorders of pregnancy, infection, diabetes, perinatal mortality and the delivery statisties in the index and control women.
Results
Maternal mortality was 1.4% and perinatal mortality was 73.3/1000 total births in women with sickle cell disease, there were no maternal deaths and the perinatal mortality was 6.8/1000 births in the control group. Anaemia was treated by blood transfusion in 47% of women with sickle cell disease and, of these, 39% had a crisis that appeared to have been precipitated by the transfusion in the absence of any other predisposing factors. The presence of raised HbF did not decrease the number of crises but reduced their severity.
Conclusion
Pregnancy in women with sickle cell disease should be monitored very closely as it constitutes a high risk to both the mother and the baby.</description><identifier>ISSN: 1470-0328</identifier><identifier>ISSN: 0306-5456</identifier><identifier>EISSN: 1471-0528</identifier><identifier>EISSN: 1365-215X</identifier><identifier>DOI: 10.1111/j.1471-0528.1992.tb14463.x</identifier><identifier>PMID: 1554657</identifier><identifier>CODEN: BJOGAS</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Anemia - complications ; Bacterial Infections - complications ; Bahrain - epidemiology ; Biological and medical sciences ; Case-Control Studies ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Hypertension - complications ; Infant Mortality ; Infant, Newborn ; Management. Prenatal diagnosis ; Medical sciences ; Pregnancy ; Pregnancy Complications, Hematologic - epidemiology ; Pregnancy Outcome - epidemiology ; Pregnancy. Fetus. Placenta ; Prevalence ; Risk Factors ; Sickle Cell Trait - epidemiology</subject><ispartof>BJOG : an international journal of obstetrics and gynaecology, 1992-02, Vol.99 (2), p.101-104</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3981-c3517ef0d90b548cb67d4ff3ee5aeb6eab6d8378f3ac533170a2de62ef9ad7033</citedby><cites>FETCH-LOGICAL-c3981-c3517ef0d90b548cb67d4ff3ee5aeb6eab6d8378f3ac533170a2de62ef9ad7033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1471-0528.1992.tb14463.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1471-0528.1992.tb14463.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5246451$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1554657$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>EL‐SHAFEI, AFFAF M.</creatorcontrib><creatorcontrib>DHALIWAL, JAGJEEVAN KAUR</creatorcontrib><creatorcontrib>SANDHU, AMARJEET KAUR</creatorcontrib><title>Pregnancy in sickle cell disease in Bahrain</title><title>BJOG : an international journal of obstetrics and gynaecology</title><addtitle>Br J Obstet Gynaecol</addtitle><description>ABSTRACT
Objective
To review the maternal and fetal complications in pregnant women with sickle cell disease and to compare their pregnancy outcome with those of controls.
Design
A case‐control study.
Setting
Ministry of Health hospitals in Bahrain.
Subjects
147 pregnancies in 140 women with sickle cell disease and 294 controls matched for age and parity
Main outcome measures
The characteristics of women who had crises, the frequency of the crises, hypertensive disorders of pregnancy, infection, diabetes, perinatal mortality and the delivery statisties in the index and control women.
Results
Maternal mortality was 1.4% and perinatal mortality was 73.3/1000 total births in women with sickle cell disease, there were no maternal deaths and the perinatal mortality was 6.8/1000 births in the control group. Anaemia was treated by blood transfusion in 47% of women with sickle cell disease and, of these, 39% had a crisis that appeared to have been precipitated by the transfusion in the absence of any other predisposing factors. The presence of raised HbF did not decrease the number of crises but reduced their severity.
Conclusion
Pregnancy in women with sickle cell disease should be monitored very closely as it constitutes a high risk to both the mother and the baby.</description><subject>Adult</subject><subject>Anemia - complications</subject><subject>Bacterial Infections - complications</subject><subject>Bahrain - epidemiology</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Hypertension - complications</subject><subject>Infant Mortality</subject><subject>Infant, Newborn</subject><subject>Management. Prenatal diagnosis</subject><subject>Medical sciences</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Hematologic - epidemiology</subject><subject>Pregnancy Outcome - epidemiology</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Prevalence</subject><subject>Risk Factors</subject><subject>Sickle Cell Trait - epidemiology</subject><issn>1470-0328</issn><issn>0306-5456</issn><issn>1471-0528</issn><issn>1365-215X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkF1LwzAUhoMoc05_glBEvJHWfLf1QnDDTwbzQq9Dmp5oZ9fNZMPt35u6Mq_NRXLI-55zXh6EzghOSDhX04TwlMRY0CwheU6TZUE4lyxZ76H-Ttr_rXGMGc0O0ZH3U4yJpJj1UI8IwaVI--jyxcF7oxuziaom8pX5rCEyUNdRWXnQHtrvof5wumqO0YHVtYeT7h2gt_u719FjPJ48PI1ux7FheUbCLUgKFpc5LgTPTCHTklvLAISGQoIuZJmxNLNMG8EYSbGmJUgKNtdlihkboIvt3IWbf63AL9Ws8m0m3cB85VVKM8kFFcF4vTUaN_fegVULV8202yiCVUtKTVWLQ7U4VEtKdaTUOjSfdltWxQzKv9YtmqCfd7r2RtfWBUiV39kE5SEECbabre27qmHzjwBq-DwhmLAfcYGERQ</recordid><startdate>199202</startdate><enddate>199202</enddate><creator>EL‐SHAFEI, AFFAF M.</creator><creator>DHALIWAL, JAGJEEVAN KAUR</creator><creator>SANDHU, AMARJEET KAUR</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199202</creationdate><title>Pregnancy in sickle cell disease in Bahrain</title><author>EL‐SHAFEI, AFFAF M. ; DHALIWAL, JAGJEEVAN KAUR ; SANDHU, AMARJEET KAUR</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3981-c3517ef0d90b548cb67d4ff3ee5aeb6eab6d8378f3ac533170a2de62ef9ad7033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adult</topic><topic>Anemia - complications</topic><topic>Bacterial Infections - complications</topic><topic>Bahrain - epidemiology</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Hypertension - complications</topic><topic>Infant Mortality</topic><topic>Infant, Newborn</topic><topic>Management. Prenatal diagnosis</topic><topic>Medical sciences</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Hematologic - epidemiology</topic><topic>Pregnancy Outcome - epidemiology</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Prevalence</topic><topic>Risk Factors</topic><topic>Sickle Cell Trait - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>EL‐SHAFEI, AFFAF M.</creatorcontrib><creatorcontrib>DHALIWAL, JAGJEEVAN KAUR</creatorcontrib><creatorcontrib>SANDHU, AMARJEET KAUR</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>EL‐SHAFEI, AFFAF M.</au><au>DHALIWAL, JAGJEEVAN KAUR</au><au>SANDHU, AMARJEET KAUR</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pregnancy in sickle cell disease in Bahrain</atitle><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle><addtitle>Br J Obstet Gynaecol</addtitle><date>1992-02</date><risdate>1992</risdate><volume>99</volume><issue>2</issue><spage>101</spage><epage>104</epage><pages>101-104</pages><issn>1470-0328</issn><issn>0306-5456</issn><eissn>1471-0528</eissn><eissn>1365-215X</eissn><coden>BJOGAS</coden><abstract>ABSTRACT
Objective
To review the maternal and fetal complications in pregnant women with sickle cell disease and to compare their pregnancy outcome with those of controls.
Design
A case‐control study.
Setting
Ministry of Health hospitals in Bahrain.
Subjects
147 pregnancies in 140 women with sickle cell disease and 294 controls matched for age and parity
Main outcome measures
The characteristics of women who had crises, the frequency of the crises, hypertensive disorders of pregnancy, infection, diabetes, perinatal mortality and the delivery statisties in the index and control women.
Results
Maternal mortality was 1.4% and perinatal mortality was 73.3/1000 total births in women with sickle cell disease, there were no maternal deaths and the perinatal mortality was 6.8/1000 births in the control group. Anaemia was treated by blood transfusion in 47% of women with sickle cell disease and, of these, 39% had a crisis that appeared to have been precipitated by the transfusion in the absence of any other predisposing factors. The presence of raised HbF did not decrease the number of crises but reduced their severity.
Conclusion
Pregnancy in women with sickle cell disease should be monitored very closely as it constitutes a high risk to both the mother and the baby.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>1554657</pmid><doi>10.1111/j.1471-0528.1992.tb14463.x</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1470-0328 |
| ispartof | BJOG : an international journal of obstetrics and gynaecology, 1992-02, Vol.99 (2), p.101-104 |
| issn | 1470-0328 0306-5456 1471-0528 1365-215X |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Adult Anemia - complications Bacterial Infections - complications Bahrain - epidemiology Biological and medical sciences Case-Control Studies Female Gynecology. Andrology. Obstetrics Humans Hypertension - complications Infant Mortality Infant, Newborn Management. Prenatal diagnosis Medical sciences Pregnancy Pregnancy Complications, Hematologic - epidemiology Pregnancy Outcome - epidemiology Pregnancy. Fetus. Placenta Prevalence Risk Factors Sickle Cell Trait - epidemiology |
| title | Pregnancy in sickle cell disease in Bahrain |
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