Dynamics of interleukin-6 internalization and degradation in rat hepatocytes

We have investigated the dissociation, internalization, and degradation of 125I-interleukin-6 (125I-IL-6) by primary rat hepatocytes. Temperature shift experiments following saturation binding of 125I-IL-6 to cell surface receptors in hepatocytes showed a rapid loss of surface-bound 125I-IL-6 (t1/2...

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Veröffentlicht in:	The Journal of biological chemistry 1992-03, Vol.267 (9), p.5739-5742
Hauptverfasser:	NESBITT, J. E, FULLER, G. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biological Transport Cell Membrane - metabolism Cell physiology Cells, Cultured Electrophoresis, Polyacrylamide Gel Endocytosis Fundamental and applied biological sciences. Psychology Hydrogen-Ion Concentration Interleukin-6 - metabolism Iodine Radioisotopes Kinetics Liver - metabolism Molecular and cellular biology Rats Rats, Inbred Strains Receptors, Immunologic - metabolism Receptors, Interleukin-6 Temperature
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