Pharmacogenomic analysis of rhIL-11 treatment in the HLA-B27 rat model of inflammatory bowel disease

Recombinant human interleukin-11 ( rhIL-11 ) reduces the clinical signs and histological lesions of inflammatory bowel disease (IBD) in transgenic rats expressing the human major histocompatability complex (MHC) class I allele, HLA-B27 . To elucidate the pharmacogenomic effects of rhIL-11 in this mo...

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Veröffentlicht in:	The hematology journal : the official journal of the European Haematology Association 2002, Vol.2 (6), p.383-399
Hauptverfasser:	Peterson, RL, Wang, L, Albert, L, Marchese, E, Erickson, J, Wong, A, Mounts, WM, Hayes, L, Bouchard, P, Keith, J, Dorner, AJ
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified Antigen presentation Antigen processing Antigens Biological and medical sciences Biomedical and Life Sciences Biomedicine Cell death Cell proliferation Digestive system Disease Models, Animal DNA microarrays Drug therapy Epithelial cells Gene Expression Gene Expression Regulation - drug effects Gene Expression Regulation - physiology Genetic aspects Growth factors Health aspects Histocompatibility antigen HLA Histocompatibility antigens HLA histocompatibility antigens HLA-B27 Antigen - biosynthesis HLA-B27 Antigen - genetics Human Genetics Humans Inflammatory bowel disease Inflammatory bowel diseases Inflammatory Bowel Diseases - drug therapy Inflammatory Bowel Diseases - genetics Interleukin 11 Interleukin-11 - pharmacology Interleukin-11 - therapeutic use Intestine Major histocompatibility complex Male Medical sciences Oligonucleotides Oncology original-article Pharmacogenetics - methods Pharmacogenetics - statistics & numerical data Pharmacogenomics Pharmacology. Drug treatments Pharmacotherapy Psychopharmacology Rats Rats, Inbred F344 Rats, Mutant Strains Recombinant Proteins - pharmacology Recombinant Proteins - therapeutic use
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