A Search for Bordetella pertussis Infection in University Students
University students with persistent cough of ⩾6 days' duration were evaluated for evidence of infection with Bordetella pertussis. Of 130 students studied during a 30-month period, 34 (26%) were found to have evidence of recent infections with B. pertussis. Infection was identified by direct fl...
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| Veröffentlicht in: | Clinical infectious diseases 1992-02, Vol.14 (2), p.464-471 |
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| container_title | Clinical infectious diseases |
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| creator | Mink, ChrisAnna Morgan Cherry, James D. Christenson, Peter Lewis, Karen Pineda, Evelyn Shlian, Deborah Dawson, Jo Ann Blumberg, Dean A. |
| description | University students with persistent cough of ⩾6 days' duration were evaluated for evidence of infection with Bordetella pertussis. Of 130 students studied during a 30-month period, 34 (26%) were found to have evidence of recent infections with B. pertussis. Infection was identified by direct fluorescent antibody assay of a nasopharyngeal specimen in one student and serologically in 33 additional subjects. B. pertussis was not recovered on culture of nasopharyngeal specimens from any subjects. Students with B. pertussis infection were identified in seven of the eight 3-month periods in which students were enrolled during the 30-month investigation, suggesting an endemic rather than epidemic pattern of infection in this university population. Illnesses of students with pertussis were similar to the illnesses of students without pertussis. The findings in this study suggest that adult populations in which endemic illness occurs at a relatively constant rate may be the reservoirs for pertussis outbreaks in susceptible children. Immunization programs in the future will need to employ booster doses for adults if complete control of B. pertussis infection is our goal. |
| doi_str_mv | 10.1093/clinids/14.2.464 |
| format | Article |
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Of 130 students studied during a 30-month period, 34 (26%) were found to have evidence of recent infections with B. pertussis. Infection was identified by direct fluorescent antibody assay of a nasopharyngeal specimen in one student and serologically in 33 additional subjects. B. pertussis was not recovered on culture of nasopharyngeal specimens from any subjects. Students with B. pertussis infection were identified in seven of the eight 3-month periods in which students were enrolled during the 30-month investigation, suggesting an endemic rather than epidemic pattern of infection in this university population. Illnesses of students with pertussis were similar to the illnesses of students without pertussis. The findings in this study suggest that adult populations in which endemic illness occurs at a relatively constant rate may be the reservoirs for pertussis outbreaks in susceptible children. Immunization programs in the future will need to employ booster doses for adults if complete control of B. pertussis infection is our goal.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1093/clinids/14.2.464</identifier><identifier>PMID: 1554832</identifier><language>eng</language><publisher>United States: The University of Chicago Press</publisher><subject>Adhesins, Bacterial ; Adult ; Adults ; Agglutination Tests ; Antibodies ; Antibodies, Bacterial - blood ; Bordetella pertussis - immunology ; Bordetella pertussis - isolation & purification ; Children ; Clinical Infectious Disease Articles ; Cough ; Diseases ; Enzyme linked immunosorbent assay ; Epidemics ; Epidemiology ; Female ; Fluorescent Antibody Technique ; Hemagglutinins - immunology ; Humans ; Infections ; Los Angeles - epidemiology ; Lymphokines - immunology ; Male ; Nasopharynx - microbiology ; Prevalence ; Prospective Studies ; Seasons ; Students ; Universities ; Virulence Factors, Bordetella ; Whooping cough ; Whooping Cough - epidemiology ; Whooping Cough - microbiology</subject><ispartof>Clinical infectious diseases, 1992-02, Vol.14 (2), p.464-471</ispartof><rights>Copyright 1992 The University of Chicago</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-1da7886bc3d74019379e79dedb8ca80b74a0bcb1b1316f35887ded483a0d97313</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/4456312$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/4456312$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1554832$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mink, ChrisAnna Morgan</creatorcontrib><creatorcontrib>Cherry, James D.</creatorcontrib><creatorcontrib>Christenson, Peter</creatorcontrib><creatorcontrib>Lewis, Karen</creatorcontrib><creatorcontrib>Pineda, Evelyn</creatorcontrib><creatorcontrib>Shlian, Deborah</creatorcontrib><creatorcontrib>Dawson, Jo Ann</creatorcontrib><creatorcontrib>Blumberg, Dean A.</creatorcontrib><title>A Search for Bordetella pertussis Infection in University Students</title><title>Clinical infectious diseases</title><addtitle>Clinical Infectious Diseases</addtitle><description>University students with persistent cough of ⩾6 days' duration were evaluated for evidence of infection with Bordetella pertussis. Of 130 students studied during a 30-month period, 34 (26%) were found to have evidence of recent infections with B. pertussis. Infection was identified by direct fluorescent antibody assay of a nasopharyngeal specimen in one student and serologically in 33 additional subjects. B. pertussis was not recovered on culture of nasopharyngeal specimens from any subjects. Students with B. pertussis infection were identified in seven of the eight 3-month periods in which students were enrolled during the 30-month investigation, suggesting an endemic rather than epidemic pattern of infection in this university population. Illnesses of students with pertussis were similar to the illnesses of students without pertussis. The findings in this study suggest that adult populations in which endemic illness occurs at a relatively constant rate may be the reservoirs for pertussis outbreaks in susceptible children. Immunization programs in the future will need to employ booster doses for adults if complete control of B. pertussis infection is our goal.</description><subject>Adhesins, Bacterial</subject><subject>Adult</subject><subject>Adults</subject><subject>Agglutination Tests</subject><subject>Antibodies</subject><subject>Antibodies, Bacterial - blood</subject><subject>Bordetella pertussis - immunology</subject><subject>Bordetella pertussis - isolation & purification</subject><subject>Children</subject><subject>Clinical Infectious Disease Articles</subject><subject>Cough</subject><subject>Diseases</subject><subject>Enzyme linked immunosorbent assay</subject><subject>Epidemics</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Fluorescent Antibody Technique</subject><subject>Hemagglutinins - immunology</subject><subject>Humans</subject><subject>Infections</subject><subject>Los Angeles - epidemiology</subject><subject>Lymphokines - immunology</subject><subject>Male</subject><subject>Nasopharynx - microbiology</subject><subject>Prevalence</subject><subject>Prospective Studies</subject><subject>Seasons</subject><subject>Students</subject><subject>Universities</subject><subject>Virulence Factors, Bordetella</subject><subject>Whooping cough</subject><subject>Whooping Cough - epidemiology</subject><subject>Whooping Cough - microbiology</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLxDAUhYMovvcuFLpy1zG3eXapgy8QFEZB3IQ0STE6045JKvrvzdBBl67u5X7nXA4HoSPAE8A1OTNz33kbz4BOqgnldAPtAiOi5KyGzbxjJksqidxBezG-YQwgMdtG28BYPle76OK8mDkdzGvR9qG46IN1yc3nuli6kIYYfSxuu9aZ5Puu8F3x1PlPF6JP38UsDdZ1KR6grVbPoztcz330dHX5OL0p7-6vb6fnd6UhkqYSrBZS8sYQKyiGmojaido620ijJW4E1bgxDTRAgLeESSkyzCk1trUgQPbR6fh3GfqPwcWkFj6aVdjO9UNUopKMc8b_FQIHIjkRWYhHoQl9jMG1ahn8QodvBVit-lXrfhVQVancb7acrH8PzcLZP8NYaObHI3-LqQ-_mNKcC1a4HLGPyX39Yh3eFRdEMHXz_KKqh0c5q2egCPkBJ96QFQ</recordid><startdate>19920201</startdate><enddate>19920201</enddate><creator>Mink, ChrisAnna Morgan</creator><creator>Cherry, James D.</creator><creator>Christenson, Peter</creator><creator>Lewis, Karen</creator><creator>Pineda, Evelyn</creator><creator>Shlian, Deborah</creator><creator>Dawson, Jo Ann</creator><creator>Blumberg, Dean A.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>19920201</creationdate><title>A Search for Bordetella pertussis Infection in University Students</title><author>Mink, ChrisAnna Morgan ; Cherry, James D. ; Christenson, Peter ; Lewis, Karen ; Pineda, Evelyn ; Shlian, Deborah ; Dawson, Jo Ann ; Blumberg, Dean A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-1da7886bc3d74019379e79dedb8ca80b74a0bcb1b1316f35887ded483a0d97313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adhesins, Bacterial</topic><topic>Adult</topic><topic>Adults</topic><topic>Agglutination Tests</topic><topic>Antibodies</topic><topic>Antibodies, Bacterial - blood</topic><topic>Bordetella pertussis - immunology</topic><topic>Bordetella pertussis - isolation & purification</topic><topic>Children</topic><topic>Clinical Infectious Disease Articles</topic><topic>Cough</topic><topic>Diseases</topic><topic>Enzyme linked immunosorbent assay</topic><topic>Epidemics</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Fluorescent Antibody Technique</topic><topic>Hemagglutinins - immunology</topic><topic>Humans</topic><topic>Infections</topic><topic>Los Angeles - epidemiology</topic><topic>Lymphokines - immunology</topic><topic>Male</topic><topic>Nasopharynx - microbiology</topic><topic>Prevalence</topic><topic>Prospective Studies</topic><topic>Seasons</topic><topic>Students</topic><topic>Universities</topic><topic>Virulence Factors, Bordetella</topic><topic>Whooping cough</topic><topic>Whooping Cough - epidemiology</topic><topic>Whooping Cough - microbiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mink, ChrisAnna Morgan</creatorcontrib><creatorcontrib>Cherry, James D.</creatorcontrib><creatorcontrib>Christenson, Peter</creatorcontrib><creatorcontrib>Lewis, Karen</creatorcontrib><creatorcontrib>Pineda, Evelyn</creatorcontrib><creatorcontrib>Shlian, Deborah</creatorcontrib><creatorcontrib>Dawson, Jo Ann</creatorcontrib><creatorcontrib>Blumberg, Dean A.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mink, ChrisAnna Morgan</au><au>Cherry, James D.</au><au>Christenson, Peter</au><au>Lewis, Karen</au><au>Pineda, Evelyn</au><au>Shlian, Deborah</au><au>Dawson, Jo Ann</au><au>Blumberg, Dean A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Search for Bordetella pertussis Infection in University Students</atitle><jtitle>Clinical infectious diseases</jtitle><addtitle>Clinical Infectious Diseases</addtitle><date>1992-02-01</date><risdate>1992</risdate><volume>14</volume><issue>2</issue><spage>464</spage><epage>471</epage><pages>464-471</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><abstract>University students with persistent cough of ⩾6 days' duration were evaluated for evidence of infection with Bordetella pertussis. Of 130 students studied during a 30-month period, 34 (26%) were found to have evidence of recent infections with B. pertussis. Infection was identified by direct fluorescent antibody assay of a nasopharyngeal specimen in one student and serologically in 33 additional subjects. B. pertussis was not recovered on culture of nasopharyngeal specimens from any subjects. Students with B. pertussis infection were identified in seven of the eight 3-month periods in which students were enrolled during the 30-month investigation, suggesting an endemic rather than epidemic pattern of infection in this university population. Illnesses of students with pertussis were similar to the illnesses of students without pertussis. The findings in this study suggest that adult populations in which endemic illness occurs at a relatively constant rate may be the reservoirs for pertussis outbreaks in susceptible children. Immunization programs in the future will need to employ booster doses for adults if complete control of B. pertussis infection is our goal.</abstract><cop>United States</cop><pub>The University of Chicago Press</pub><pmid>1554832</pmid><doi>10.1093/clinids/14.2.464</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Clinical infectious diseases, 1992-02, Vol.14 (2), p.464-471 |
| issn | 1058-4838 1537-6591 |
| language | eng |
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| source | Oxford University Press Journals Digital Archive legacy; MEDLINE; JSTOR Archive Collection A-Z Listing |
| subjects | Adhesins, Bacterial Adult Adults Agglutination Tests Antibodies Antibodies, Bacterial - blood Bordetella pertussis - immunology Bordetella pertussis - isolation & purification Children Clinical Infectious Disease Articles Cough Diseases Enzyme linked immunosorbent assay Epidemics Epidemiology Female Fluorescent Antibody Technique Hemagglutinins - immunology Humans Infections Los Angeles - epidemiology Lymphokines - immunology Male Nasopharynx - microbiology Prevalence Prospective Studies Seasons Students Universities Virulence Factors, Bordetella Whooping cough Whooping Cough - epidemiology Whooping Cough - microbiology |
| title | A Search for Bordetella pertussis Infection in University Students |
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