Endocrine responses and ovarian changes in inseminated dairy heifers after an injection of a GnRH agonist 11 to 13 days after estrus
Our objective in this study was to determine endocrine responses and changes in ovarian structures after a single injection of a GnRH agonist in Holstein dairy heifers (n = 38). Heifers were inseminated and received (i.m.) either saline or 200 micrograms of fertirelin acetate once on d 11, 12, or 13...
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| Veröffentlicht in: | Journal of animal science 1992-02, Vol.70 (2), p.508-517 |
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| creator | Rettmer, I Stevenson, J. S Corah, L. R |
| description | Our objective in this study was to determine endocrine responses and changes in ovarian structures after a single injection of a GnRH agonist in Holstein dairy heifers (n = 38). Heifers were inseminated and received (i.m.) either saline or 200 micrograms of fertirelin acetate once on d 11, 12, or 13 after estrus (d 0). Blood was collected at 15- to 30-min intervals for 6 h after the injection to determine concentrations of LH, FSH, estradiol (E), and progesterone (P) in serum and once daily for 8 to 12 d after the injection to determine concentrations of E and P. Pregnancy rates were 58% (11 of 19) in both treatment groups. Diameter of the corpus luteum and numbers and appearance of ovarian follicles were determined by real-time ultrasonography on d-1 through 5 after injection. No treatment-induced ovulations or changes in the number of ovarian follicles were observed after the injection of the GnRH agonist. More (P less than .05) of the largest follicles within heifers receiving fertirelin acetate showed changes in their appearance on at least the 1st d after injection (6 of 10 vs 1 of 9 control heifers). Fertirelin acetate induced release of LH and FSH from the pituitary within 15 min of injection; both hormones reached peak concentrations at 120 min and then returned to pretreatment concentrations by 300 to 360 min after injection. |
| doi_str_mv | 10.2527/1992.702508x |
| format | Article |
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S ; Corah, L. R</creator><creatorcontrib>Rettmer, I ; Stevenson, J. S ; Corah, L. R</creatorcontrib><description>Our objective in this study was to determine endocrine responses and changes in ovarian structures after a single injection of a GnRH agonist in Holstein dairy heifers (n = 38). Heifers were inseminated and received (i.m.) either saline or 200 micrograms of fertirelin acetate once on d 11, 12, or 13 after estrus (d 0). Blood was collected at 15- to 30-min intervals for 6 h after the injection to determine concentrations of LH, FSH, estradiol (E), and progesterone (P) in serum and once daily for 8 to 12 d after the injection to determine concentrations of E and P. Pregnancy rates were 58% (11 of 19) in both treatment groups. Diameter of the corpus luteum and numbers and appearance of ovarian follicles were determined by real-time ultrasonography on d-1 through 5 after injection. No treatment-induced ovulations or changes in the number of ovarian follicles were observed after the injection of the GnRH agonist. More (P less than .05) of the largest follicles within heifers receiving fertirelin acetate showed changes in their appearance on at least the 1st d after injection (6 of 10 vs 1 of 9 control heifers). Fertirelin acetate induced release of LH and FSH from the pituitary within 15 min of injection; both hormones reached peak concentrations at 120 min and then returned to pretreatment concentrations by 300 to 360 min after injection.</description><identifier>ISSN: 0021-8812</identifier><identifier>EISSN: 1525-3163</identifier><identifier>DOI: 10.2527/1992.702508x</identifier><identifier>PMID: 1548214</identifier><language>eng</language><publisher>Savoy, IL: Am Soc Animal Sci</publisher><subject>Animal productions ; Animals ; Biological and medical sciences ; Breeding of animals ; Cattle ; Cattle - physiology ; Corpus Luteum - diagnostic imaging ; Corpus Luteum - drug effects ; Corpus Luteum - physiology ; Estradiol - blood ; Female ; Fertilization - drug effects ; Follicle Stimulating Hormone - blood ; Fundamental and applied biological sciences. Psychology ; Gonadotropin-Releasing Hormone - administration & dosage ; Gonadotropin-Releasing Hormone - analogs & derivatives ; Gonadotropin-Releasing Hormone - pharmacology ; Hormones ; Hormones - administration & dosage ; Hormones - blood ; Hormones - pharmacology ; Injections - veterinary ; Insemination, Artificial - veterinary ; Luteinizing Hormone - blood ; Ovarian Follicle - diagnostic imaging ; Ovarian Follicle - drug effects ; Ovary - diagnostic imaging ; Ovary - drug effects ; Pregnancy ; Progesterone - blood ; Random Allocation ; Terrestrial animal productions ; Ultrasonography ; Vertebrates</subject><ispartof>Journal of animal science, 1992-02, Vol.70 (2), p.508-517</ispartof><rights>1992 INIST-CNRS</rights><rights>Copyright American Society of Animal Science Feb 1992</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5214809$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1548214$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rettmer, I</creatorcontrib><creatorcontrib>Stevenson, J. S</creatorcontrib><creatorcontrib>Corah, L. R</creatorcontrib><title>Endocrine responses and ovarian changes in inseminated dairy heifers after an injection of a GnRH agonist 11 to 13 days after estrus</title><title>Journal of animal science</title><addtitle>J Anim Sci</addtitle><description>Our objective in this study was to determine endocrine responses and changes in ovarian structures after a single injection of a GnRH agonist in Holstein dairy heifers (n = 38). Heifers were inseminated and received (i.m.) either saline or 200 micrograms of fertirelin acetate once on d 11, 12, or 13 after estrus (d 0). Blood was collected at 15- to 30-min intervals for 6 h after the injection to determine concentrations of LH, FSH, estradiol (E), and progesterone (P) in serum and once daily for 8 to 12 d after the injection to determine concentrations of E and P. Pregnancy rates were 58% (11 of 19) in both treatment groups. Diameter of the corpus luteum and numbers and appearance of ovarian follicles were determined by real-time ultrasonography on d-1 through 5 after injection. No treatment-induced ovulations or changes in the number of ovarian follicles were observed after the injection of the GnRH agonist. More (P less than .05) of the largest follicles within heifers receiving fertirelin acetate showed changes in their appearance on at least the 1st d after injection (6 of 10 vs 1 of 9 control heifers). Fertirelin acetate induced release of LH and FSH from the pituitary within 15 min of injection; both hormones reached peak concentrations at 120 min and then returned to pretreatment concentrations by 300 to 360 min after injection.</description><subject>Animal productions</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Breeding of animals</subject><subject>Cattle</subject><subject>Cattle - physiology</subject><subject>Corpus Luteum - diagnostic imaging</subject><subject>Corpus Luteum - drug effects</subject><subject>Corpus Luteum - physiology</subject><subject>Estradiol - blood</subject><subject>Female</subject><subject>Fertilization - drug effects</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gonadotropin-Releasing Hormone - administration & dosage</subject><subject>Gonadotropin-Releasing Hormone - analogs & derivatives</subject><subject>Gonadotropin-Releasing Hormone - pharmacology</subject><subject>Hormones</subject><subject>Hormones - administration & dosage</subject><subject>Hormones - blood</subject><subject>Hormones - pharmacology</subject><subject>Injections - veterinary</subject><subject>Insemination, Artificial - veterinary</subject><subject>Luteinizing Hormone - blood</subject><subject>Ovarian Follicle - diagnostic imaging</subject><subject>Ovarian Follicle - drug effects</subject><subject>Ovary - diagnostic imaging</subject><subject>Ovary - drug effects</subject><subject>Pregnancy</subject><subject>Progesterone - blood</subject><subject>Random Allocation</subject><subject>Terrestrial animal productions</subject><subject>Ultrasonography</subject><subject>Vertebrates</subject><issn>0021-8812</issn><issn>1525-3163</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc9rFTEQx4Mo9bV68yoEUW9bM0mzmxyl1FYoCNJ7mObH2zx2k2eyq767f7gpffYgBCZkPt_vZGYIeQPsnEs-fAKt-fnAuGTq9zOyAcllJ6AXz8mGMQ6dUsBfktNad4wBl1qekBOQF4rDxYb8uUou2xKTp8XXfU7VV4rJ0fwTS8RE7Yhp295iaqf6OSZcvKMOYznQ0cfgSxOExZcma8jO2yXmRHOgSK_T9xuK25xiXSgAXTIF0bSHfxJfl7LWV-RFwKn618d4Ru6-XN1d3nS3366_Xn6-7Uau-dIFDb3iQTKpW7vYC-0Hp7kIGKwTfY_OKWBOPtwYKqkdOmGRg_O9tffijHx8tN2X_GNtpc0cq_XThMnntZqBKwmiVw189x-4y2tJ7WuGgwIhOHuA3h6h9X72zuxLnLEczHG0Lf_-mMdqcQoFk431CZONUUw37MMjNsbt-CsWb-qM09RMweywDsxw0zYr_gJJW5Q5</recordid><startdate>19920201</startdate><enddate>19920201</enddate><creator>Rettmer, I</creator><creator>Stevenson, J. S</creator><creator>Corah, L. R</creator><general>Am Soc Animal Sci</general><general>American Society of Animal Science</general><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>K9.</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>19920201</creationdate><title>Endocrine responses and ovarian changes in inseminated dairy heifers after an injection of a GnRH agonist 11 to 13 days after estrus</title><author>Rettmer, I ; Stevenson, J. S ; Corah, L. R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h292t-f91682f5059702a639e7d923fafcd366add810d566ad0a859dad3ca21de6ccb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animal productions</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Breeding of animals</topic><topic>Cattle</topic><topic>Cattle - physiology</topic><topic>Corpus Luteum - diagnostic imaging</topic><topic>Corpus Luteum - drug effects</topic><topic>Corpus Luteum - physiology</topic><topic>Estradiol - blood</topic><topic>Female</topic><topic>Fertilization - drug effects</topic><topic>Follicle Stimulating Hormone - blood</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gonadotropin-Releasing Hormone - administration & dosage</topic><topic>Gonadotropin-Releasing Hormone - analogs & derivatives</topic><topic>Gonadotropin-Releasing Hormone - pharmacology</topic><topic>Hormones</topic><topic>Hormones - administration & dosage</topic><topic>Hormones - blood</topic><topic>Hormones - pharmacology</topic><topic>Injections - veterinary</topic><topic>Insemination, Artificial - veterinary</topic><topic>Luteinizing Hormone - blood</topic><topic>Ovarian Follicle - diagnostic imaging</topic><topic>Ovarian Follicle - drug effects</topic><topic>Ovary - diagnostic imaging</topic><topic>Ovary - drug effects</topic><topic>Pregnancy</topic><topic>Progesterone - blood</topic><topic>Random Allocation</topic><topic>Terrestrial animal productions</topic><topic>Ultrasonography</topic><topic>Vertebrates</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rettmer, I</creatorcontrib><creatorcontrib>Stevenson, J. S</creatorcontrib><creatorcontrib>Corah, L. R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of animal science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rettmer, I</au><au>Stevenson, J. S</au><au>Corah, L. R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endocrine responses and ovarian changes in inseminated dairy heifers after an injection of a GnRH agonist 11 to 13 days after estrus</atitle><jtitle>Journal of animal science</jtitle><addtitle>J Anim Sci</addtitle><date>1992-02-01</date><risdate>1992</risdate><volume>70</volume><issue>2</issue><spage>508</spage><epage>517</epage><pages>508-517</pages><issn>0021-8812</issn><eissn>1525-3163</eissn><abstract>Our objective in this study was to determine endocrine responses and changes in ovarian structures after a single injection of a GnRH agonist in Holstein dairy heifers (n = 38). Heifers were inseminated and received (i.m.) either saline or 200 micrograms of fertirelin acetate once on d 11, 12, or 13 after estrus (d 0). Blood was collected at 15- to 30-min intervals for 6 h after the injection to determine concentrations of LH, FSH, estradiol (E), and progesterone (P) in serum and once daily for 8 to 12 d after the injection to determine concentrations of E and P. Pregnancy rates were 58% (11 of 19) in both treatment groups. Diameter of the corpus luteum and numbers and appearance of ovarian follicles were determined by real-time ultrasonography on d-1 through 5 after injection. No treatment-induced ovulations or changes in the number of ovarian follicles were observed after the injection of the GnRH agonist. More (P less than .05) of the largest follicles within heifers receiving fertirelin acetate showed changes in their appearance on at least the 1st d after injection (6 of 10 vs 1 of 9 control heifers). Fertirelin acetate induced release of LH and FSH from the pituitary within 15 min of injection; both hormones reached peak concentrations at 120 min and then returned to pretreatment concentrations by 300 to 360 min after injection.</abstract><cop>Savoy, IL</cop><pub>Am Soc Animal Sci</pub><pmid>1548214</pmid><doi>10.2527/1992.702508x</doi><tpages>10</tpages></addata></record> |
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| subjects | Animal productions Animals Biological and medical sciences Breeding of animals Cattle Cattle - physiology Corpus Luteum - diagnostic imaging Corpus Luteum - drug effects Corpus Luteum - physiology Estradiol - blood Female Fertilization - drug effects Follicle Stimulating Hormone - blood Fundamental and applied biological sciences. Psychology Gonadotropin-Releasing Hormone - administration & dosage Gonadotropin-Releasing Hormone - analogs & derivatives Gonadotropin-Releasing Hormone - pharmacology Hormones Hormones - administration & dosage Hormones - blood Hormones - pharmacology Injections - veterinary Insemination, Artificial - veterinary Luteinizing Hormone - blood Ovarian Follicle - diagnostic imaging Ovarian Follicle - drug effects Ovary - diagnostic imaging Ovary - drug effects Pregnancy Progesterone - blood Random Allocation Terrestrial animal productions Ultrasonography Vertebrates |
| title | Endocrine responses and ovarian changes in inseminated dairy heifers after an injection of a GnRH agonist 11 to 13 days after estrus |
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