A density-sensing factor controls development in Dictyostelium
For an unknown reason, several genes expressed during Dictyostelium development are regulated by cell density. This is mediated by an 80-kD glycoprotein, conditioned medium factor (CMF), which is slowly secreted and simultaneously sensed by starved cells. To examine further this eukaryotic cell dens...
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| Veröffentlicht in: | Genes & development 1992-03, Vol.6 (3), p.390-400 |
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| creator | JAIN, R YUEN, I. S TAPHOUSE, C. R GOMER, R. H |
| description | For an unknown reason, several genes expressed during Dictyostelium development are regulated by cell density. This is mediated by an 80-kD glycoprotein, conditioned medium factor (CMF), which is slowly secreted and simultaneously sensed by starved cells. To examine further this eukaryotic cell density-sensing mechanism, we have isolated a cDNA encoding CMF. The derived amino acid sequence of CMF shows no obvious similarity to any known protein and thus may represent a new class of eukaryotic intercellular signal. CMF antisense transformants do not aggregate, whereas normal development is restored by the addition of purified CMF protein. This suggests that CMF might synchronize the onset of development in Dictyostelium by triggering aggregation when a majority of the cells in a given area have starved, as signaled by CMF secretion. |
| doi_str_mv | 10.1101/gad.6.3.390 |
| format | Article |
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S</au><au>TAPHOUSE, C. R</au><au>GOMER, R. H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A density-sensing factor controls development in Dictyostelium</atitle><jtitle>Genes & development</jtitle><addtitle>Genes Dev</addtitle><date>1992-03-01</date><risdate>1992</risdate><volume>6</volume><issue>3</issue><spage>390</spage><epage>400</epage><pages>390-400</pages><issn>0890-9369</issn><eissn>1549-5477</eissn><coden>GEDEEP</coden><abstract>For an unknown reason, several genes expressed during Dictyostelium development are regulated by cell density. This is mediated by an 80-kD glycoprotein, conditioned medium factor (CMF), which is slowly secreted and simultaneously sensed by starved cells. To examine further this eukaryotic cell density-sensing mechanism, we have isolated a cDNA encoding CMF. The derived amino acid sequence of CMF shows no obvious similarity to any known protein and thus may represent a new class of eukaryotic intercellular signal. 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| subjects | Amino Acid Sequence Animals Base Sequence Biological and medical sciences Blotting, Northern Blotting, Southern Cell Adhesion Molecules - genetics Cell Aggregation - genetics conditioned medium factor Dictyostelium - genetics Dictyostelium - growth & development DNA, Fungal - genetics Fundamental and applied biological sciences. Psychology genes Genes, Fungal Genes. Genome Glycoproteins - genetics Glycoproteins - metabolism Molecular and cellular biology Molecular genetics Molecular Sequence Data Nucleic Acid Hybridization Protozoan Proteins RNA, Fungal - genetics RNA, Messenger - genetics Transformation, Genetic |
| title | A density-sensing factor controls development in Dictyostelium |
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