Diagnosis of hairy leukoplakia by exfoliative cytologic methods
The cytologic characteristics of hairy leukoplakia (HL) are described based on the findings observed in four lesions. All cases were confirmed by histologic study, and Epstein-Barr virus DNA was detected by means of in situ hybridization of tissue sections. All smears from the lesions exhibited a di...
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| Veröffentlicht in: | American journal of clinical pathology 1992-02, Vol.97 (2), p.262-266 |
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| creator | FRAGA-FERNANDEZ, J VICANDI-PLAZA, B |
| description | The cytologic characteristics of hairy leukoplakia (HL) are described based on the findings observed in four lesions. All cases were confirmed by histologic study, and Epstein-Barr virus DNA was detected by means of in situ hybridization of tissue sections. All smears from the lesions exhibited a distinctive appearance and three types of epithelial changes were observed: (1) intranuclear inclusions of Cowdry type A, (2) intranuclear inclusions with a ground-glass appearance, and (3) clumping and margination of chromatin around the nuclear membrane. Other findings were the presence of bacterial colonies in all lesions and Candida organisms in three of them. The results of this study suggest that conventional exfoliative cytologic examination may prove to be a useful, simple, cost-effective, and reliable method to diagnose hairy leukoplakia. |
| doi_str_mv | 10.1093/ajcp/97.2.262 |
| format | Article |
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All cases were confirmed by histologic study, and Epstein-Barr virus DNA was detected by means of in situ hybridization of tissue sections. All smears from the lesions exhibited a distinctive appearance and three types of epithelial changes were observed: (1) intranuclear inclusions of Cowdry type A, (2) intranuclear inclusions with a ground-glass appearance, and (3) clumping and margination of chromatin around the nuclear membrane. Other findings were the presence of bacterial colonies in all lesions and Candida organisms in three of them. The results of this study suggest that conventional exfoliative cytologic examination may prove to be a useful, simple, cost-effective, and reliable method to diagnose hairy leukoplakia.</description><identifier>ISSN: 0002-9173</identifier><identifier>EISSN: 1943-7722</identifier><identifier>DOI: 10.1093/ajcp/97.2.262</identifier><identifier>PMID: 1372148</identifier><identifier>CODEN: AJCPAI</identifier><language>eng</language><publisher>Chicago, IL: American Society of Clinical Pathologists</publisher><subject>Adult ; Biological and medical sciences ; Candida - isolation & purification ; Cell Nucleus - ultrastructure ; Cytological Techniques ; Female ; Humans ; Immunodeficiencies ; Immunodeficiencies. 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All cases were confirmed by histologic study, and Epstein-Barr virus DNA was detected by means of in situ hybridization of tissue sections. All smears from the lesions exhibited a distinctive appearance and three types of epithelial changes were observed: (1) intranuclear inclusions of Cowdry type A, (2) intranuclear inclusions with a ground-glass appearance, and (3) clumping and margination of chromatin around the nuclear membrane. Other findings were the presence of bacterial colonies in all lesions and Candida organisms in three of them. The results of this study suggest that conventional exfoliative cytologic examination may prove to be a useful, simple, cost-effective, and reliable method to diagnose hairy leukoplakia.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Candida - isolation & purification</subject><subject>Cell Nucleus - ultrastructure</subject><subject>Cytological Techniques</subject><subject>Female</subject><subject>Humans</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Inclusion Bodies - ultrastructure</subject><subject>Leukoplakia, Oral - microbiology</subject><subject>Leukoplakia, Oral - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Staining and Labeling</subject><issn>0002-9173</issn><issn>1943-7722</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkDtPwzAYRS0EKqUwMiJlQGxp_UpsTwiVp1SJpbv1xXFat04d4hSRf0-qVjDd4R6d4SB0S_CUYMVmsDHNTIkpndKcnqExUZylQlB6jsYYY5oqItgluopxgzGhEvMRGhEmKOFyjB6fHax2IbqYhCpZg2v7xNv9NjQetg6Sok_sTxW8g85928T0XfBh5UxS224dyniNLirw0d6cdoKWry_L-Xu6-Hz7mD8tUsOI6FIwDAoCRMhcQFkJlZU85yI3SkKGcZkZW3AhFJeKqJzIgpaQ8YopQUpgik3Qw1HbtOFrb2OnaxeN9R52NuyjFlTyTPJ8ANMjaNoQY2sr3bSuhrbXBOtDL33opZXQVA-9Bv7uJN4XtS3_6WOg4b8__RAN-KqFnXHxD8tolnOcs18CdnL9</recordid><startdate>19920201</startdate><enddate>19920201</enddate><creator>FRAGA-FERNANDEZ, J</creator><creator>VICANDI-PLAZA, B</creator><general>American Society of Clinical Pathologists</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19920201</creationdate><title>Diagnosis of hairy leukoplakia by exfoliative cytologic methods</title><author>FRAGA-FERNANDEZ, J ; VICANDI-PLAZA, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c317t-ac3ab1a17867adf795d46476c98a500d5ceb477948919618b2da54f3971da393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Candida - isolation & purification</topic><topic>Cell Nucleus - ultrastructure</topic><topic>Cytological Techniques</topic><topic>Female</topic><topic>Humans</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Inclusion Bodies - ultrastructure</topic><topic>Leukoplakia, Oral - microbiology</topic><topic>Leukoplakia, Oral - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Staining and Labeling</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FRAGA-FERNANDEZ, J</creatorcontrib><creatorcontrib>VICANDI-PLAZA, B</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of clinical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FRAGA-FERNANDEZ, J</au><au>VICANDI-PLAZA, B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnosis of hairy leukoplakia by exfoliative cytologic methods</atitle><jtitle>American journal of clinical pathology</jtitle><addtitle>Am J Clin Pathol</addtitle><date>1992-02-01</date><risdate>1992</risdate><volume>97</volume><issue>2</issue><spage>262</spage><epage>266</epage><pages>262-266</pages><issn>0002-9173</issn><eissn>1943-7722</eissn><coden>AJCPAI</coden><abstract>The cytologic characteristics of hairy leukoplakia (HL) are described based on the findings observed in four lesions. All cases were confirmed by histologic study, and Epstein-Barr virus DNA was detected by means of in situ hybridization of tissue sections. All smears from the lesions exhibited a distinctive appearance and three types of epithelial changes were observed: (1) intranuclear inclusions of Cowdry type A, (2) intranuclear inclusions with a ground-glass appearance, and (3) clumping and margination of chromatin around the nuclear membrane. Other findings were the presence of bacterial colonies in all lesions and Candida organisms in three of them. The results of this study suggest that conventional exfoliative cytologic examination may prove to be a useful, simple, cost-effective, and reliable method to diagnose hairy leukoplakia.</abstract><cop>Chicago, IL</cop><pub>American Society of Clinical Pathologists</pub><pmid>1372148</pmid><doi>10.1093/ajcp/97.2.262</doi><tpages>5</tpages></addata></record> |
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| ispartof | American journal of clinical pathology, 1992-02, Vol.97 (2), p.262-266 |
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| source | Oxford University Press Journals Digital Archive legacy; MEDLINE |
| subjects | Adult Biological and medical sciences Candida - isolation & purification Cell Nucleus - ultrastructure Cytological Techniques Female Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Inclusion Bodies - ultrastructure Leukoplakia, Oral - microbiology Leukoplakia, Oral - pathology Male Medical sciences Middle Aged Staining and Labeling |
| title | Diagnosis of hairy leukoplakia by exfoliative cytologic methods |
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