Isolated HLA-DP mismatches between donors and recipients do not influence the function or outcome of renal transplants
The matching of donors and renal graft recipients for human leukocyte antigens A, B, and DR has been shown to exert beneficial effects on the outcome of transplantation. Until the advent of polymerase chain reaction amplification-based genotyping, the effect of HLA-DP compatibility on graft survival...
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| Veröffentlicht in: | Human immunology 1992, Vol.33 (1), p.5-9 |
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| container_title | Human immunology |
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| creator | Rosenberg, William M.C. Bushell, Andrew Higgins, Robert M. Wordsworth, B.Paul Wood, Kathryn J. Bell, John I. Morris, Peter J. |
| description | The matching of donors and renal graft recipients for human leukocyte antigens A, B, and DR has been shown to exert beneficial effects on the outcome of transplantation. Until the advent of polymerase chain reaction amplification-based genotyping, the effect of HLA-DP compatibility on graft survival could not be thoroughly investigated. HLA-DP compatibility has been determined in three living-related transplants and 34 cadaveric transplants for donor-recipient pairs matched for HLA-DR and -DQ. The effect of DP mismatching on graft survival and function was assessed. No clear benefit from matching donor and recipient for HLA-DP could be discerned. |
| doi_str_mv | 10.1016/0198-8859(92)90045-O |
| format | Article |
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Until the advent of polymerase chain reaction amplification-based genotyping, the effect of HLA-DP compatibility on graft survival could not be thoroughly investigated. HLA-DP compatibility has been determined in three living-related transplants and 34 cadaveric transplants for donor-recipient pairs matched for HLA-DR and -DQ. The effect of DP mismatching on graft survival and function was assessed. No clear benefit from matching donor and recipient for HLA-DP could be discerned.</description><identifier>ISSN: 0198-8859</identifier><identifier>EISSN: 1879-1166</identifier><identifier>DOI: 10.1016/0198-8859(92)90045-O</identifier><identifier>PMID: 1548149</identifier><identifier>CODEN: HUIMDQ</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Base Sequence ; Biological and medical sciences ; DNA Probes ; Fundamental and applied biological sciences. 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Psychology</subject><subject>Fundamental immunology</subject><subject>Graft Rejection - immunology</subject><subject>Histocompatibility - immunology</subject><subject>Histocompatibility Testing</subject><subject>HLA-DP Antigens - immunology</subject><subject>HLA-DQ Antigens - immunology</subject><subject>HLA-DR Antigens - immunology</subject><subject>Humans</subject><subject>Kidney Transplantation - immunology</subject><subject>Molecular Sequence Data</subject><subject>Polymerase Chain Reaction</subject><subject>Retrospective Studies</subject><subject>Tissue Donors</subject><subject>Tissue, organ and graft immunology</subject><issn>0198-8859</issn><issn>1879-1166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFrFTEUhYMo9Vn9BwpZiNTFaDKTmSQbobTaFh68LroPSeaGRmaSZ5Kp-O_N9D3qzq4Cud-5nHsOQu8p-UIJHb4SKkUjRC_PZPtZEsL6ZvcCbajgsqF0GF6izRPyGr3J-SchhBPOTtAJ7ZmgTG7Qw02Oky4w4uvteXN5i2efZ13sPWRsoPwGCHiMIaaMdRhxAuv3HkLJ9ReHWLAPblogWMDlHrBbgi0-BhwTjkuxcQYcXZUFPeGSdMj7SVf1W_TK6SnDu-N7iu5-fL-7uG62u6ubi_NtY9kgSsOZIMBH21tntRug76gR4KzrGDNGamhNx3lLZEfaQQ7GCM2NIdQKPkpKulP06bB2n-KvBXJR9TwLU_UAccmKt4L1gvTPgnSgfdvRoYLsANoUc07g1D75Wac_ihK11qLWzNWauZKteqxF7arsw3H_YmYY_4kOPdT5x-NcZ6snV5OyPj9hPWVMtqvNbwcMamYPHpLK1q_hj742U9QY_f99_AV4W6q8</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>Rosenberg, William M.C.</creator><creator>Bushell, Andrew</creator><creator>Higgins, Robert M.</creator><creator>Wordsworth, B.Paul</creator><creator>Wood, Kathryn J.</creator><creator>Bell, John I.</creator><creator>Morris, Peter J.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>1992</creationdate><title>Isolated HLA-DP mismatches between donors and recipients do not influence the function or outcome of renal transplants</title><author>Rosenberg, William M.C. ; Bushell, Andrew ; Higgins, Robert M. ; Wordsworth, B.Paul ; Wood, Kathryn J. ; Bell, John I. ; Morris, Peter J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-7480e7dc5cfcaf6e531b8efcf344bb9ae2b377209302696bb8a7bb01c87d9103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>DNA Probes</topic><topic>Fundamental and applied biological sciences. 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Until the advent of polymerase chain reaction amplification-based genotyping, the effect of HLA-DP compatibility on graft survival could not be thoroughly investigated. HLA-DP compatibility has been determined in three living-related transplants and 34 cadaveric transplants for donor-recipient pairs matched for HLA-DR and -DQ. The effect of DP mismatching on graft survival and function was assessed. No clear benefit from matching donor and recipient for HLA-DP could be discerned.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>1548149</pmid><doi>10.1016/0198-8859(92)90045-O</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0198-8859 |
| ispartof | Human immunology, 1992, Vol.33 (1), p.5-9 |
| issn | 0198-8859 1879-1166 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Base Sequence Biological and medical sciences DNA Probes Fundamental and applied biological sciences. Psychology Fundamental immunology Graft Rejection - immunology Histocompatibility - immunology Histocompatibility Testing HLA-DP Antigens - immunology HLA-DQ Antigens - immunology HLA-DR Antigens - immunology Humans Kidney Transplantation - immunology Molecular Sequence Data Polymerase Chain Reaction Retrospective Studies Tissue Donors Tissue, organ and graft immunology |
| title | Isolated HLA-DP mismatches between donors and recipients do not influence the function or outcome of renal transplants |
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