An analysis of prognostic factors in cutaneous neuroendocrine carcinoma
Since the first report of cutaneous neuroendocrine carcinoma (Merkel cell carcinoma) in 1972, knowledge of the biological behavior of this tumor has continued to increase. This study reviews three previously unreported cases in addition to reports on 429 patients collected from the literature. The p...
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| Veröffentlicht in: | The Laryngoscope 1992-03, Vol.102 (3), p.244-249 |
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| container_title | The Laryngoscope |
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| creator | Pitale, Michèle Sessions, Roy B. Husain, Shaista |
| description | Since the first report of cutaneous neuroendocrine carcinoma (Merkel cell carcinoma) in 1972, knowledge of the biological behavior of this tumor has continued to increase. This study reviews three previously unreported cases in addition to reports on 429 patients collected from the literature. The presenting features of these 306 patients were analyzed for frequency and then were analyzed by the Cox proportional hazard model for the relationship of each to recurrence and outcome. This study confirms that cutaneous neuroendocrine carcinoma is an aggressive disease; that the most common cause of death in these patients is by distant metastasis; and that men have succumbed more frequently than women. As a result of this study, aggressive treatment of cutaneous neuroendocrine carcinoma is recommended, especially in the male patient. |
| doi_str_mv | 10.1288/00005537-199203000-00003 |
| format | Article |
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This study reviews three previously unreported cases in addition to reports on 429 patients collected from the literature. The presenting features of these 306 patients were analyzed for frequency and then were analyzed by the Cox proportional hazard model for the relationship of each to recurrence and outcome. This study confirms that cutaneous neuroendocrine carcinoma is an aggressive disease; that the most common cause of death in these patients is by distant metastasis; and that men have succumbed more frequently than women. As a result of this study, aggressive treatment of cutaneous neuroendocrine carcinoma is recommended, especially in the male patient.</description><identifier>ISSN: 0023-852X</identifier><identifier>EISSN: 1531-4995</identifier><identifier>DOI: 10.1288/00005537-199203000-00003</identifier><identifier>PMID: 1545650</identifier><identifier>CODEN: LARYA8</identifier><language>eng</language><publisher>Hoboken, NJ: John Wiley & Sons, Inc</publisher><subject>Aged ; Aged, 80 and over ; Biological and medical sciences ; Carcinoma, Merkel Cell - epidemiology ; Carcinoma, Merkel Cell - mortality ; Dermatology ; Humans ; Lymphatic Metastasis ; Male ; Medical sciences ; Neoplasm Recurrence, Local - epidemiology ; Neoplasm Recurrence, Local - mortality ; Prognosis ; Proportional Hazards Models ; Risk Factors ; Sex Factors ; Skin Neoplasms - epidemiology ; Skin Neoplasms - mortality ; Tumors of the skin and soft tissue. 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This study reviews three previously unreported cases in addition to reports on 429 patients collected from the literature. The presenting features of these 306 patients were analyzed for frequency and then were analyzed by the Cox proportional hazard model for the relationship of each to recurrence and outcome. This study confirms that cutaneous neuroendocrine carcinoma is an aggressive disease; that the most common cause of death in these patients is by distant metastasis; and that men have succumbed more frequently than women. As a result of this study, aggressive treatment of cutaneous neuroendocrine carcinoma is recommended, especially in the male patient.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Merkel Cell - epidemiology</subject><subject>Carcinoma, Merkel Cell - mortality</subject><subject>Dermatology</subject><subject>Humans</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neoplasm Recurrence, Local - epidemiology</subject><subject>Neoplasm Recurrence, Local - mortality</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Risk Factors</subject><subject>Sex Factors</subject><subject>Skin Neoplasms - epidemiology</subject><subject>Skin Neoplasms - mortality</subject><subject>Tumors of the skin and soft tissue. Premalignant lesions</subject><issn>0023-852X</issn><issn>1531-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUMFuEzEQtRCopIVPQNoD4rbF9njW3mNUaAqKQKoKhJPlODYybOxi76rk79llQ7gyl9G8efPm6RFSMXrJuFKv6ViIIGvWtpzCONUTBI_IgiGwWrQtPiYLSjnUCvnmKTkv5TulTALSM3LGUGCDdEFWy1iZaLpDCaVKvrrP6VtMpQ-28sb2KZcqxMoOvYkuDaWKbsjJxV2yOURXWZNtiGlvnpEn3nTFPT_2C_Lp-u3d1U29_rh6d7Vc1xYBoLZCOSda2kjmuWmsB86842haxb0DoK3dNkpIjzsHijvYMiq2gvlG7qhsBVyQV7PuaPTn4Eqv96FY13WzPy25EgIaNRLVTLQ5lZKd1_c57E0-aEb1lKH-m6E-ZfgHgvH0xfHHsN273b_DObRx__K4N8WazmcTbSgnGnJUVExW38y0h9C5w3-_1-vl7VdEweiETm7qWSaU3v06yZj8QzcSJOovH1b68zXg-w2g3sBvituadg</recordid><startdate>199203</startdate><enddate>199203</enddate><creator>Pitale, Michèle</creator><creator>Sessions, Roy B.</creator><creator>Husain, Shaista</creator><general>John Wiley & Sons, Inc</general><general>Wiley-Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>199203</creationdate><title>An analysis of prognostic factors in cutaneous neuroendocrine carcinoma</title><author>Pitale, Michèle ; Sessions, Roy B. ; Husain, Shaista</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5333-c48ee490671f2a6cf321fe25a982fe3309cb6847f5de382e3b104b41f67d07943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Merkel Cell - epidemiology</topic><topic>Carcinoma, Merkel Cell - mortality</topic><topic>Dermatology</topic><topic>Humans</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neoplasm Recurrence, Local - epidemiology</topic><topic>Neoplasm Recurrence, Local - mortality</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Risk Factors</topic><topic>Sex Factors</topic><topic>Skin Neoplasms - epidemiology</topic><topic>Skin Neoplasms - mortality</topic><topic>Tumors of the skin and soft tissue. Premalignant lesions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pitale, Michèle</creatorcontrib><creatorcontrib>Sessions, Roy B.</creatorcontrib><creatorcontrib>Husain, Shaista</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>The Laryngoscope</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pitale, Michèle</au><au>Sessions, Roy B.</au><au>Husain, Shaista</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An analysis of prognostic factors in cutaneous neuroendocrine carcinoma</atitle><jtitle>The Laryngoscope</jtitle><addtitle>The Laryngoscope</addtitle><date>1992-03</date><risdate>1992</risdate><volume>102</volume><issue>3</issue><spage>244</spage><epage>249</epage><pages>244-249</pages><issn>0023-852X</issn><eissn>1531-4995</eissn><coden>LARYA8</coden><abstract>Since the first report of cutaneous neuroendocrine carcinoma (Merkel cell carcinoma) in 1972, knowledge of the biological behavior of this tumor has continued to increase. This study reviews three previously unreported cases in addition to reports on 429 patients collected from the literature. The presenting features of these 306 patients were analyzed for frequency and then were analyzed by the Cox proportional hazard model for the relationship of each to recurrence and outcome. This study confirms that cutaneous neuroendocrine carcinoma is an aggressive disease; that the most common cause of death in these patients is by distant metastasis; and that men have succumbed more frequently than women. As a result of this study, aggressive treatment of cutaneous neuroendocrine carcinoma is recommended, especially in the male patient.</abstract><cop>Hoboken, NJ</cop><pub>John Wiley & Sons, Inc</pub><pmid>1545650</pmid><doi>10.1288/00005537-199203000-00003</doi><tpages>6</tpages></addata></record> |
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| ispartof | The Laryngoscope, 1992-03, Vol.102 (3), p.244-249 |
| issn | 0023-852X 1531-4995 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Aged Aged, 80 and over Biological and medical sciences Carcinoma, Merkel Cell - epidemiology Carcinoma, Merkel Cell - mortality Dermatology Humans Lymphatic Metastasis Male Medical sciences Neoplasm Recurrence, Local - epidemiology Neoplasm Recurrence, Local - mortality Prognosis Proportional Hazards Models Risk Factors Sex Factors Skin Neoplasms - epidemiology Skin Neoplasms - mortality Tumors of the skin and soft tissue. Premalignant lesions |
| title | An analysis of prognostic factors in cutaneous neuroendocrine carcinoma |
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