Prothymosin alpha enhances human and murine MHC class II surface antigen expression and messenger RNA accumulation

Prothymosin alpha (ProT alpha) is an acidic polypeptide with potentiating effects on HLA-DR-restricted in vitro cellular immune response systems such as T cell proliferative responses to soluble proteins and cellular auto- or alloantigens. Experiments were performed to investigate the effect of ProT...

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Veröffentlicht in:	The Journal of immunology (1950) 1992-04, Vol.148 (7), p.1979-1984
Hauptverfasser:	Baxevanis, CN, Thanos, D, Reclos, GJ, Anastasopoulos, E, Tsokos, GC, Papamatheakis, J, Papamichail, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of the immune response. Humoral and cellular immunity Animals Biological and medical sciences Cell Line Fundamental and applied biological sciences. Psychology Fundamental immunology Gene Expression Regulation Histocompatibility Antigens Class II - genetics HLA-DR Antigens - analysis HLA-DR Antigens - genetics Humans Immunobiology Interferon-gamma - pharmacology Mice Mice, Inbred BALB C Miscellaneous Monocytes - immunology Protein Precursors - pharmacology Regulatory factors and their cellular receptors RNA, Messenger - analysis Thymosin - analogs & derivatives Thymosin - pharmacology Up-Regulation
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