Breast cancer prognosis in Tunisian women: analysis of a hospital series of 729 patients
The objective of this study was to identify the anatomical-clinical aspects and determine the prognostic factors for breast cancer in the central region of Tunisia. This retrospective study involved 729 patients suffering from breast cancer, proven either by histology or cytology, diagnosed and trea...
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| Veröffentlicht in: | Santé publique (Vandoeuvre-lès-Nancy, France) France), 2002-09, Vol.14 (3), p.231-241 |
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| creator | Ben Ahmed, S Aloulou, S Bibi, M Landolsi, A Nouira, M Ben Fatma, L Kallel, L Gharbi, O Korbi, S Khaïri, H Kraïem, C |
| description | The objective of this study was to identify the anatomical-clinical aspects and determine the prognostic factors for breast cancer in the central region of Tunisia. This retrospective study involved 729 patients suffering from breast cancer, proven either by histology or cytology, diagnosed and treated between January 1990 and June 1998 at the F. Hached University Hospital in Sousse, Tunisia. The patients' average age was 50 years (ranging from 22-91). The average size of the cancer at the time of diagnosis was 49.1 mm; 90% were invasive duct carcinoma with high histo-prognostic SBR grade (level II-III: 86%). The overall survival rate was 50.5% after five years, and 50% after seven years. Using univariate analysis, significant predictive value was found with the following factors: tumor size, the clinical ganglionic level, metastases at diagnosis, the number of nodes invaded, nodal capsular rupture and lymphatic embolism, SBR grade and the delay in seeking consultation. The multivariate analysis (Cox model) isolated two prognostic factors: the initial size of the tumor (p = 0.001) and metastases at the time of diagnosis (p = 0.01). The study's results indicated that breast cancer prognosis in Tunisia remains poor primarily due to late diagnosis. |
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This retrospective study involved 729 patients suffering from breast cancer, proven either by histology or cytology, diagnosed and treated between January 1990 and June 1998 at the F. Hached University Hospital in Sousse, Tunisia. The patients' average age was 50 years (ranging from 22-91). The average size of the cancer at the time of diagnosis was 49.1 mm; 90% were invasive duct carcinoma with high histo-prognostic SBR grade (level II-III: 86%). The overall survival rate was 50.5% after five years, and 50% after seven years. Using univariate analysis, significant predictive value was found with the following factors: tumor size, the clinical ganglionic level, metastases at diagnosis, the number of nodes invaded, nodal capsular rupture and lymphatic embolism, SBR grade and the delay in seeking consultation. The multivariate analysis (Cox model) isolated two prognostic factors: the initial size of the tumor (p = 0.001) and metastases at the time of diagnosis (p = 0.01). The study's results indicated that breast cancer prognosis in Tunisia remains poor primarily due to late diagnosis.</description><identifier>ISSN: 0995-3914</identifier><identifier>PMID: 12564048</identifier><language>fre</language><publisher>France</publisher><subject>Adult ; Age Distribution ; Aged ; Aged, 80 and over ; Analysis of Variance ; Biopsy ; Breast Neoplasms - mortality ; Breast Neoplasms - pathology ; Breast Neoplasms - therapy ; Carcinoma, Ductal, Breast - mortality ; Carcinoma, Ductal, Breast - pathology ; Carcinoma, Ductal, Breast - therapy ; Combined Modality Therapy ; Female ; Humans ; Mastectomy - methods ; Middle Aged ; Neoplasm Staging ; Predictive Value of Tests ; Prognosis ; Proportional Hazards Models ; Retrospective Studies ; Survival Analysis ; Time Factors ; Treatment Outcome ; Tunisia - epidemiology</subject><ispartof>Santé publique (Vandoeuvre-lès-Nancy, France), 2002-09, Vol.14 (3), p.231-241</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12564048$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ben Ahmed, S</creatorcontrib><creatorcontrib>Aloulou, S</creatorcontrib><creatorcontrib>Bibi, M</creatorcontrib><creatorcontrib>Landolsi, A</creatorcontrib><creatorcontrib>Nouira, M</creatorcontrib><creatorcontrib>Ben Fatma, L</creatorcontrib><creatorcontrib>Kallel, L</creatorcontrib><creatorcontrib>Gharbi, O</creatorcontrib><creatorcontrib>Korbi, S</creatorcontrib><creatorcontrib>Khaïri, H</creatorcontrib><creatorcontrib>Kraïem, C</creatorcontrib><title>Breast cancer prognosis in Tunisian women: analysis of a hospital series of 729 patients</title><title>Santé publique (Vandoeuvre-lès-Nancy, France)</title><addtitle>Sante Publique</addtitle><description>The objective of this study was to identify the anatomical-clinical aspects and determine the prognostic factors for breast cancer in the central region of Tunisia. This retrospective study involved 729 patients suffering from breast cancer, proven either by histology or cytology, diagnosed and treated between January 1990 and June 1998 at the F. Hached University Hospital in Sousse, Tunisia. The patients' average age was 50 years (ranging from 22-91). The average size of the cancer at the time of diagnosis was 49.1 mm; 90% were invasive duct carcinoma with high histo-prognostic SBR grade (level II-III: 86%). The overall survival rate was 50.5% after five years, and 50% after seven years. Using univariate analysis, significant predictive value was found with the following factors: tumor size, the clinical ganglionic level, metastases at diagnosis, the number of nodes invaded, nodal capsular rupture and lymphatic embolism, SBR grade and the delay in seeking consultation. The multivariate analysis (Cox model) isolated two prognostic factors: the initial size of the tumor (p = 0.001) and metastases at the time of diagnosis (p = 0.01). The study's results indicated that breast cancer prognosis in Tunisia remains poor primarily due to late diagnosis.</description><subject>Adult</subject><subject>Age Distribution</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analysis of Variance</subject><subject>Biopsy</subject><subject>Breast Neoplasms - mortality</subject><subject>Breast Neoplasms - pathology</subject><subject>Breast Neoplasms - therapy</subject><subject>Carcinoma, Ductal, Breast - mortality</subject><subject>Carcinoma, Ductal, Breast - pathology</subject><subject>Carcinoma, Ductal, Breast - therapy</subject><subject>Combined Modality Therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Mastectomy - methods</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Retrospective Studies</subject><subject>Survival Analysis</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Tunisia - epidemiology</subject><issn>0995-3914</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1UE1LxDAUzEFx19W_IDl5KyRtkibedPELFjy4B2_lNX3VSJvWvBbZf2_9Og3MDMPMHLG1cE5nhZNqxU6J3oUw0qnihK1kro0Syq7Zy01CoIl7iB4TH9PwGgcKxEPk-zkGChD559BjvOIQoTt8a0PLgb8NNIYJOk6YAv6QZe74CFPAONEZO26hIzz_ww17vrvdbx-y3dP94_Z6l41a2azwjbI-B-mkRqONb1oEVK02BpbedWNRNbaphXIapSyNVqZ2rRawDPC22LDL39Sl-MeMNFV9II9dBxGHmaoyt6ootViMF3_Gue6xqcYUekiH6v-J4gsAGVlD</recordid><startdate>200209</startdate><enddate>200209</enddate><creator>Ben Ahmed, S</creator><creator>Aloulou, S</creator><creator>Bibi, M</creator><creator>Landolsi, A</creator><creator>Nouira, M</creator><creator>Ben Fatma, L</creator><creator>Kallel, L</creator><creator>Gharbi, O</creator><creator>Korbi, S</creator><creator>Khaïri, H</creator><creator>Kraïem, C</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200209</creationdate><title>Breast cancer prognosis in Tunisian women: analysis of a hospital series of 729 patients</title><author>Ben Ahmed, S ; Aloulou, S ; Bibi, M ; Landolsi, A ; Nouira, M ; Ben Fatma, L ; Kallel, L ; Gharbi, O ; Korbi, S ; Khaïri, H ; Kraïem, C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p548-3cd48c2a1915e656cdfeae4f566a914bd8e4d8db0495e1176546b9f50a564c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>fre</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Age Distribution</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Analysis of Variance</topic><topic>Biopsy</topic><topic>Breast Neoplasms - mortality</topic><topic>Breast Neoplasms - pathology</topic><topic>Breast Neoplasms - therapy</topic><topic>Carcinoma, Ductal, Breast - mortality</topic><topic>Carcinoma, Ductal, Breast - pathology</topic><topic>Carcinoma, Ductal, Breast - therapy</topic><topic>Combined Modality Therapy</topic><topic>Female</topic><topic>Humans</topic><topic>Mastectomy - methods</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Retrospective Studies</topic><topic>Survival Analysis</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Tunisia - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ben Ahmed, S</creatorcontrib><creatorcontrib>Aloulou, S</creatorcontrib><creatorcontrib>Bibi, M</creatorcontrib><creatorcontrib>Landolsi, A</creatorcontrib><creatorcontrib>Nouira, M</creatorcontrib><creatorcontrib>Ben Fatma, L</creatorcontrib><creatorcontrib>Kallel, L</creatorcontrib><creatorcontrib>Gharbi, O</creatorcontrib><creatorcontrib>Korbi, S</creatorcontrib><creatorcontrib>Khaïri, H</creatorcontrib><creatorcontrib>Kraïem, C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Santé publique (Vandoeuvre-lès-Nancy, France)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ben Ahmed, S</au><au>Aloulou, S</au><au>Bibi, M</au><au>Landolsi, A</au><au>Nouira, M</au><au>Ben Fatma, L</au><au>Kallel, L</au><au>Gharbi, O</au><au>Korbi, S</au><au>Khaïri, H</au><au>Kraïem, C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Breast cancer prognosis in Tunisian women: analysis of a hospital series of 729 patients</atitle><jtitle>Santé publique (Vandoeuvre-lès-Nancy, France)</jtitle><addtitle>Sante Publique</addtitle><date>2002-09</date><risdate>2002</risdate><volume>14</volume><issue>3</issue><spage>231</spage><epage>241</epage><pages>231-241</pages><issn>0995-3914</issn><abstract>The objective of this study was to identify the anatomical-clinical aspects and determine the prognostic factors for breast cancer in the central region of Tunisia. This retrospective study involved 729 patients suffering from breast cancer, proven either by histology or cytology, diagnosed and treated between January 1990 and June 1998 at the F. Hached University Hospital in Sousse, Tunisia. The patients' average age was 50 years (ranging from 22-91). The average size of the cancer at the time of diagnosis was 49.1 mm; 90% were invasive duct carcinoma with high histo-prognostic SBR grade (level II-III: 86%). The overall survival rate was 50.5% after five years, and 50% after seven years. Using univariate analysis, significant predictive value was found with the following factors: tumor size, the clinical ganglionic level, metastases at diagnosis, the number of nodes invaded, nodal capsular rupture and lymphatic embolism, SBR grade and the delay in seeking consultation. The multivariate analysis (Cox model) isolated two prognostic factors: the initial size of the tumor (p = 0.001) and metastases at the time of diagnosis (p = 0.01). The study's results indicated that breast cancer prognosis in Tunisia remains poor primarily due to late diagnosis.</abstract><cop>France</cop><pmid>12564048</pmid><tpages>11</tpages></addata></record> |
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| subjects | Adult Age Distribution Aged Aged, 80 and over Analysis of Variance Biopsy Breast Neoplasms - mortality Breast Neoplasms - pathology Breast Neoplasms - therapy Carcinoma, Ductal, Breast - mortality Carcinoma, Ductal, Breast - pathology Carcinoma, Ductal, Breast - therapy Combined Modality Therapy Female Humans Mastectomy - methods Middle Aged Neoplasm Staging Predictive Value of Tests Prognosis Proportional Hazards Models Retrospective Studies Survival Analysis Time Factors Treatment Outcome Tunisia - epidemiology |
| title | Breast cancer prognosis in Tunisian women: analysis of a hospital series of 729 patients |
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