Possible participation of endogenous opioid peptides on the mechanism involved in analgesia induced by vouacapan
The involvement of opioid peptides in the mechanism of action of vouacapan, a new experimental compound extracted from seeds of Pterodon poligalaeflorus Benth, was investigated both in mice utilizing acetic acid writhing response and in rats utilizing inflammatory hyperalgesia induced by carrageenan...
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| Veröffentlicht in: | Life sciences (1973) 1992, Vol.50 (12), p.891-897 |
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| creator | Duarte, Igor D.G. Ferreira-Alves, Dalton L. Nakamura-Craig, Meire |
| description | The involvement of opioid peptides in the mechanism of action of vouacapan, a new experimental compound extracted from seeds of
Pterodon poligalaeflorus
Benth, was investigated both in mice utilizing acetic acid writhing response and in rats utilizing inflammatory hyperalgesia induced by carrageenan and modified Randall-Selitto method. Vouacapan, in both models, caused a dose-dependent analgesia when injected p.o., s.c. and i.p. The analgesic effect was partially blocked by naloxone, nalorphine and n-methyl-nalorphine. Significant tolerance to analgesic effect was observed following repeated administration of vouacapan or morphine. On the last day of treatment, cross administration revealed symmetrical and asymmetrical cross-tolerance between vouacapan and morphine, in rats and mice, respectively. We conclude that a release of endorphins could be involved in the analgesic mechanism of vouacapan in both models studied. |
| doi_str_mv | 10.1016/0024-3205(92)90208-7 |
| format | Article |
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Pterodon poligalaeflorus
Benth, was investigated both in mice utilizing acetic acid writhing response and in rats utilizing inflammatory hyperalgesia induced by carrageenan and modified Randall-Selitto method. Vouacapan, in both models, caused a dose-dependent analgesia when injected p.o., s.c. and i.p. The analgesic effect was partially blocked by naloxone, nalorphine and n-methyl-nalorphine. Significant tolerance to analgesic effect was observed following repeated administration of vouacapan or morphine. On the last day of treatment, cross administration revealed symmetrical and asymmetrical cross-tolerance between vouacapan and morphine, in rats and mice, respectively. We conclude that a release of endorphins could be involved in the analgesic mechanism of vouacapan in both models studied.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/0024-3205(92)90208-7</identifier><identifier>PMID: 1545667</identifier><identifier>CODEN: LIFSAK</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject><![CDATA[analgesia ; ANALGESICOS ; Analgesics - administration & dosage ; Analgesics - antagonists & inhibitors ; ANALGESIQUE ; Animals ; Biological and medical sciences ; Diterpenes - administration & dosage ; Diterpenes - antagonists & inhibitors ; Drug Administration Routes ; Drug Tolerance ; endogenous ; Endorphins - physiology ; EXTRACTOS VEGETALES ; EXTRAIT D'ORIGINE VEGETALE ; General pharmacology ; GRAINE ; induction ; Male ; Medical sciences ; Mice ; Morphine - administration & dosage ; Nalorphine - analogs & derivatives ; Nalorphine - pharmacology ; Naloxone - pharmacology ; opioids ; Pain Measurement - drug effects ; PEPTIDE ; PEPTIDOS ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; PLANTAS MEDICINALES ; PLANTE MEDICINALE ; RAT ; RATA ; RATON ; Rats ; Rats, Inbred Strains ; requirements ; SEMILLA ; SOURIS ; vovacapan]]></subject><ispartof>Life sciences (1973), 1992, Vol.50 (12), p.891-897</ispartof><rights>1992</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c461t-e7b615aeea87941a6a9922bec4d73413e2ff76826e21a86af1f7c7c39e6444a83</citedby><cites>FETCH-LOGICAL-c461t-e7b615aeea87941a6a9922bec4d73413e2ff76826e21a86af1f7c7c39e6444a83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0024320592902087$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,4009,27902,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5204728$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1545667$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Duarte, Igor D.G.</creatorcontrib><creatorcontrib>Ferreira-Alves, Dalton L.</creatorcontrib><creatorcontrib>Nakamura-Craig, Meire</creatorcontrib><title>Possible participation of endogenous opioid peptides on the mechanism involved in analgesia induced by vouacapan</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>The involvement of opioid peptides in the mechanism of action of vouacapan, a new experimental compound extracted from seeds of
Pterodon poligalaeflorus
Benth, was investigated both in mice utilizing acetic acid writhing response and in rats utilizing inflammatory hyperalgesia induced by carrageenan and modified Randall-Selitto method. Vouacapan, in both models, caused a dose-dependent analgesia when injected p.o., s.c. and i.p. The analgesic effect was partially blocked by naloxone, nalorphine and n-methyl-nalorphine. Significant tolerance to analgesic effect was observed following repeated administration of vouacapan or morphine. On the last day of treatment, cross administration revealed symmetrical and asymmetrical cross-tolerance between vouacapan and morphine, in rats and mice, respectively. We conclude that a release of endorphins could be involved in the analgesic mechanism of vouacapan in both models studied.</description><subject>analgesia</subject><subject>ANALGESICOS</subject><subject>Analgesics - administration & dosage</subject><subject>Analgesics - antagonists & inhibitors</subject><subject>ANALGESIQUE</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Diterpenes - administration & dosage</subject><subject>Diterpenes - antagonists & inhibitors</subject><subject>Drug Administration Routes</subject><subject>Drug Tolerance</subject><subject>endogenous</subject><subject>Endorphins - physiology</subject><subject>EXTRACTOS VEGETALES</subject><subject>EXTRAIT D'ORIGINE VEGETALE</subject><subject>General pharmacology</subject><subject>GRAINE</subject><subject>induction</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Morphine - administration & dosage</subject><subject>Nalorphine - analogs & derivatives</subject><subject>Nalorphine - pharmacology</subject><subject>Naloxone - pharmacology</subject><subject>opioids</subject><subject>Pain Measurement - drug effects</subject><subject>PEPTIDE</subject><subject>PEPTIDOS</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>PLANTAS MEDICINALES</subject><subject>PLANTE MEDICINALE</subject><subject>RAT</subject><subject>RATA</subject><subject>RATON</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>requirements</subject><subject>SEMILLA</subject><subject>SOURIS</subject><subject>vovacapan</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV2L1TAQhoMo69nVPyAKuZBFL6pJmo_2RpDFL1hQ0L0O03R6NtImNWkP7L83xx7WO71KJu-Tl5l3CHnO2RvOuH7LmJBVLZh61YrXLROsqcwDsuONaSuma_6Q7O6Rx-Q855-MMaVMfUbOuJJKa7Mj87eYs-9GpDOkxTs_w-JjoHGgGPq4xxDXTOPso-_pjPPieyx1oMst0gndLQSfJ-rDIY4H7MuFQoBxj9lDKfrVlcfujh7iCg5mCE_IowHGjE9P5wW5-fjhx9Xn6vrrpy9X768rJzVfKjSd5goQoYwjOWhoWyE6dLI3teQ1imEwuhEaBYdGw8AH44yrW9RSSmjqC3K5-c4p_loxL3by2eE4QsAykjWikVwL81-Qa81Uq1UB5Qa6VDJLONg5-QnSneXMHjdij3HbY9y2FfbPRuzR_8XJf-0m7P9-2lZQ9JcnHbKDcUgQnM_3mBJMll4L9mzDBogW9qkgN99b3gjFZBHfbSKWRA8ek83OYyjZ-4RusX30_27yN0SosJs</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>Duarte, Igor D.G.</creator><creator>Ferreira-Alves, Dalton L.</creator><creator>Nakamura-Craig, Meire</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>1992</creationdate><title>Possible participation of endogenous opioid peptides on the mechanism involved in analgesia induced by vouacapan</title><author>Duarte, Igor D.G. ; Ferreira-Alves, Dalton L. ; Nakamura-Craig, Meire</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c461t-e7b615aeea87941a6a9922bec4d73413e2ff76826e21a86af1f7c7c39e6444a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>analgesia</topic><topic>ANALGESICOS</topic><topic>Analgesics - administration & dosage</topic><topic>Analgesics - antagonists & inhibitors</topic><topic>ANALGESIQUE</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Diterpenes - administration & dosage</topic><topic>Diterpenes - antagonists & inhibitors</topic><topic>Drug Administration Routes</topic><topic>Drug Tolerance</topic><topic>endogenous</topic><topic>Endorphins - physiology</topic><topic>EXTRACTOS VEGETALES</topic><topic>EXTRAIT D'ORIGINE VEGETALE</topic><topic>General pharmacology</topic><topic>GRAINE</topic><topic>induction</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Morphine - administration & dosage</topic><topic>Nalorphine - analogs & derivatives</topic><topic>Nalorphine - pharmacology</topic><topic>Naloxone - pharmacology</topic><topic>opioids</topic><topic>Pain Measurement - drug effects</topic><topic>PEPTIDE</topic><topic>PEPTIDOS</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>PLANTAS MEDICINALES</topic><topic>PLANTE MEDICINALE</topic><topic>RAT</topic><topic>RATA</topic><topic>RATON</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>requirements</topic><topic>SEMILLA</topic><topic>SOURIS</topic><topic>vovacapan</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Duarte, Igor D.G.</creatorcontrib><creatorcontrib>Ferreira-Alves, Dalton L.</creatorcontrib><creatorcontrib>Nakamura-Craig, Meire</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Duarte, Igor D.G.</au><au>Ferreira-Alves, Dalton L.</au><au>Nakamura-Craig, Meire</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Possible participation of endogenous opioid peptides on the mechanism involved in analgesia induced by vouacapan</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>1992</date><risdate>1992</risdate><volume>50</volume><issue>12</issue><spage>891</spage><epage>897</epage><pages>891-897</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><coden>LIFSAK</coden><abstract>The involvement of opioid peptides in the mechanism of action of vouacapan, a new experimental compound extracted from seeds of
Pterodon poligalaeflorus
Benth, was investigated both in mice utilizing acetic acid writhing response and in rats utilizing inflammatory hyperalgesia induced by carrageenan and modified Randall-Selitto method. Vouacapan, in both models, caused a dose-dependent analgesia when injected p.o., s.c. and i.p. The analgesic effect was partially blocked by naloxone, nalorphine and n-methyl-nalorphine. Significant tolerance to analgesic effect was observed following repeated administration of vouacapan or morphine. On the last day of treatment, cross administration revealed symmetrical and asymmetrical cross-tolerance between vouacapan and morphine, in rats and mice, respectively. We conclude that a release of endorphins could be involved in the analgesic mechanism of vouacapan in both models studied.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>1545667</pmid><doi>10.1016/0024-3205(92)90208-7</doi><tpages>7</tpages></addata></record> |
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| subjects | analgesia ANALGESICOS Analgesics - administration & dosage Analgesics - antagonists & inhibitors ANALGESIQUE Animals Biological and medical sciences Diterpenes - administration & dosage Diterpenes - antagonists & inhibitors Drug Administration Routes Drug Tolerance endogenous Endorphins - physiology EXTRACTOS VEGETALES EXTRAIT D'ORIGINE VEGETALE General pharmacology GRAINE induction Male Medical sciences Mice Morphine - administration & dosage Nalorphine - analogs & derivatives Nalorphine - pharmacology Naloxone - pharmacology opioids Pain Measurement - drug effects PEPTIDE PEPTIDOS Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments PLANTAS MEDICINALES PLANTE MEDICINALE RAT RATA RATON Rats Rats, Inbred Strains requirements SEMILLA SOURIS vovacapan |
| title | Possible participation of endogenous opioid peptides on the mechanism involved in analgesia induced by vouacapan |
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