alpha.-Methyl polyamines: metabolically stable spermidine and spermine mimics capable of supporting growth in cells depleted of polyamines

In order to assess the tolerance of the target enzyme spermine synthase for alpha-substituents on the aminopropyl moiety of the substrate spermidine, 1-methylspermidine (MeSpd, 2) was synthesized. It was determined that MeSpd is a poor substrate for spermine synthase and is not a substrate for sperm...

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Veröffentlicht in:	Journal of medicinal chemistry 1992-02, Vol.35 (4), p.724-734
Hauptverfasser:	Lakanen, John R, Coward, James K, Pegg, Anthony E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Division - drug effects Cell Line, Transformed Colonic Neoplasms - pathology Eflornithine - pharmacology Humans Leukemia L1210 - metabolism Leukemia L1210 - pathology Methylation Mice Putrescine - metabolism Spermidine - analogs & derivatives Spermidine - chemical synthesis Spermidine - metabolism Spermidine - pharmacology Spermine - analogs & derivatives Spermine - chemical synthesis Spermine - metabolism Spermine - pharmacology Spermine Synthase - metabolism Substrate Specificity Tumor Cells, Cultured
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