Control of New World cutaneous leishmaniasis is IL‐12 independent but STAT4 dependent

Leishmania mexicana, a New World protozoan parasite, induces small, chronic, but non‐progressive lesions in C57BL/6 (B6) mice. In this study we investigated the role of IL‐12, and subsequent Th1 factors, in controlling cutaneous L. mexicana infection. IL‐12 treatment failed to promote disease resolu...

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Veröffentlicht in:	European journal of immunology 2002-11, Vol.32 (11), p.3206-3215
Hauptverfasser:	Buxbaum, Laurence U., Uzonna, Jude E., Goldschmidt, Michael H., Scott, Phillip
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CD8-Positive T-Lymphocytes - immunology Cytokine DNA-Binding Proteins - physiology Inflammation Interferon-gamma - physiology Interleukin-12 - physiology Interleukin-12 Subunit p40 Leishmaniasis, Cutaneous - immunology Leishmaniasis, Cutaneous - pathology Mice Mice, Inbred C3H Mice, Inbred C57BL Mice, Knockout Nitric Oxide Synthase - physiology Nitric Oxide Synthase Type II Parasitic protozoa Protein Subunits - physiology STAT4 Transcription Factor Th1/Th2 cell Trans-Activators - physiology Transgenic/knockout
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