Glioblastoma, transforming growth factor-β, and Candida meningitis: A potential link
The development of Candida meningitis in a patient following partial resection of a glioblastoma raised suspicion that transforming growth factor (TGF-β), an immunosuppressive cytokine known to be produced by this tumor, would be elevated in his cerebrospinal fluid (CSF). By using a highly specific...
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| Veröffentlicht in: | The American journal of medicine 1992-03, Vol.92 (3), p.262-264 |
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| container_title | The American journal of medicine |
| container_volume | 92 |
| creator | Peterson, Phillip K. Chao, Chun C. Hu, Shuxian Thielen, Kim Shaskan, Edward G. |
| description | The development of
Candida meningitis in a patient following partial resection of a glioblastoma raised suspicion that transforming growth factor (TGF-β), an immunosuppressive cytokine known to be produced by this tumor, would be elevated in his cerebrospinal fluid (CSF). By using a highly specific bioassay, the concentration of TGF-β was found to be 609 pg/mL, which was 10-fold greater than the mean CSF TGF-β value in control subjects with no neurologic disease. Increased CSF TGF-β levels were also detected in patients with other central nervous system (CNS) diseases: malignancies and AIDS dementia complex. These findings suggest that TGF-β may play an immunopathogenetic role in the CNS. |
| doi_str_mv | 10.1016/0002-9343(92)90075-M |
| format | Article |
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Candida meningitis in a patient following partial resection of a glioblastoma raised suspicion that transforming growth factor (TGF-β), an immunosuppressive cytokine known to be produced by this tumor, would be elevated in his cerebrospinal fluid (CSF). By using a highly specific bioassay, the concentration of TGF-β was found to be 609 pg/mL, which was 10-fold greater than the mean CSF TGF-β value in control subjects with no neurologic disease. Increased CSF TGF-β levels were also detected in patients with other central nervous system (CNS) diseases: malignancies and AIDS dementia complex. 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Chao, Chun C. ; Hu, Shuxian ; Thielen, Kim ; Shaskan, Edward G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-95b61b55bfc8aee439b50afe6924c8b8e009c2a1001005502a604d27f48828533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Acquired Immunodeficiency Syndrome - cerebrospinal fluid</topic><topic>Acquired Immunodeficiency Syndrome - immunology</topic><topic>AIDS/HIV</topic><topic>Biological and medical sciences</topic><topic>Brain Neoplasms - cerebrospinal fluid</topic><topic>Brain Neoplasms - immunology</topic><topic>Brain Neoplasms - surgery</topic><topic>Candidiasis - cerebrospinal fluid</topic><topic>Candidiasis - etiology</topic><topic>Candidiasis - immunology</topic><topic>Glioblastoma - cerebrospinal fluid</topic><topic>Glioblastoma - immunology</topic><topic>Glioblastoma - surgery</topic><topic>Humans</topic><topic>Immunity, Cellular - immunology</topic><topic>Immunocompromised Host - immunology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Meningitis, Fungal - cerebrospinal fluid</topic><topic>Meningitis, Fungal - etiology</topic><topic>Meningitis, Fungal - immunology</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Postoperative Complications - cerebrospinal fluid</topic><topic>Postoperative Complications - etiology</topic><topic>Postoperative Complications - immunology</topic><topic>Transforming Growth Factor beta - cerebrospinal fluid</topic><topic>Transforming Growth Factor beta - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Peterson, Phillip K.</creatorcontrib><creatorcontrib>Chao, Chun C.</creatorcontrib><creatorcontrib>Hu, Shuxian</creatorcontrib><creatorcontrib>Thielen, Kim</creatorcontrib><creatorcontrib>Shaskan, Edward G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peterson, Phillip K.</au><au>Chao, Chun C.</au><au>Hu, Shuxian</au><au>Thielen, Kim</au><au>Shaskan, Edward G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glioblastoma, transforming growth factor-β, and Candida meningitis: A potential link</atitle><jtitle>The American journal of medicine</jtitle><addtitle>Am J Med</addtitle><date>1992-03-01</date><risdate>1992</risdate><volume>92</volume><issue>3</issue><spage>262</spage><epage>264</epage><pages>262-264</pages><issn>0002-9343</issn><eissn>1555-7162</eissn><coden>AJMEAZ</coden><abstract>The development of
Candida meningitis in a patient following partial resection of a glioblastoma raised suspicion that transforming growth factor (TGF-β), an immunosuppressive cytokine known to be produced by this tumor, would be elevated in his cerebrospinal fluid (CSF). By using a highly specific bioassay, the concentration of TGF-β was found to be 609 pg/mL, which was 10-fold greater than the mean CSF TGF-β value in control subjects with no neurologic disease. Increased CSF TGF-β levels were also detected in patients with other central nervous system (CNS) diseases: malignancies and AIDS dementia complex. These findings suggest that TGF-β may play an immunopathogenetic role in the CNS.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>1312305</pmid><doi>10.1016/0002-9343(92)90075-M</doi><tpages>3</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acquired Immunodeficiency Syndrome - cerebrospinal fluid Acquired Immunodeficiency Syndrome - immunology AIDS/HIV Biological and medical sciences Brain Neoplasms - cerebrospinal fluid Brain Neoplasms - immunology Brain Neoplasms - surgery Candidiasis - cerebrospinal fluid Candidiasis - etiology Candidiasis - immunology Glioblastoma - cerebrospinal fluid Glioblastoma - immunology Glioblastoma - surgery Humans Immunity, Cellular - immunology Immunocompromised Host - immunology Male Medical sciences Meningitis, Fungal - cerebrospinal fluid Meningitis, Fungal - etiology Meningitis, Fungal - immunology Middle Aged Neurology Postoperative Complications - cerebrospinal fluid Postoperative Complications - etiology Postoperative Complications - immunology Transforming Growth Factor beta - cerebrospinal fluid Transforming Growth Factor beta - immunology |
| title | Glioblastoma, transforming growth factor-β, and Candida meningitis: A potential link |
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