An inactivated vaccine against ringworm

A new vaccine against ringworm, containing the inactivated Trichophyton verrucosum strain, was assessed on guinea pigs and calves under experimental conditions and on three herds of cattle under natural conditions. The vaccine elicited a distinct immune response of the cellular type. This type of im...

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Veröffentlicht in:Comparative Immunology, Microbiology and Infectious Diseases Microbiology and Infectious Diseases, 1992, Vol.15 (1), p.31-40
Hauptverfasser: Wawrzkiewicz, K., Wawrzkiewicz, J.
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description A new vaccine against ringworm, containing the inactivated Trichophyton verrucosum strain, was assessed on guinea pigs and calves under experimental conditions and on three herds of cattle under natural conditions. The vaccine elicited a distinct immune response of the cellular type. This type of immunity assessed by the migration inhibition test of leukocytes corresponded to the immunity evaluated by the challenge. In herds in which there were from 30 to 67% of naturally infected animals with T. verrucosum, two doses of the vaccine resulted in after 4 weeks a decrease of the number of animals with clinical changes from 40.5 to 100% depending on the group of animals under study. L'efficacité d'un nouveau vaccin inactivé contre la trichophytie du bétail a été étudiée sur des cobayes et des veaux dans des conditions expérimentales et sur 3 troupeaux de bétail dans des conditions de contagion naturelle. Le vaccin contenant la souche Trichophyton verrucosum a entraîné une nette réponse immunologique du type cellulaire. La réaction immunologique, appréciée à l'aide du test d'inhibition de migration du leucocytes etait en correlation avec l'immunité, déterminée par epreuve infestante. Dans les troupeaux où 30 à 67% d'animaux ont été infestés avec la souche T. verrucosum on a constaté après 4 semaines, après avoir reçu deux doses de vaccin, une diminution du nombre de'animaux présentant des symptômes cliniques de maladie dans la proposition de 40,5% a 100% par rapport au temoins.
doi_str_mv 10.1016/0147-9571(92)90099-D
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The vaccine elicited a distinct immune response of the cellular type. This type of immunity assessed by the migration inhibition test of leukocytes corresponded to the immunity evaluated by the challenge. In herds in which there were from 30 to 67% of naturally infected animals with T. verrucosum, two doses of the vaccine resulted in after 4 weeks a decrease of the number of animals with clinical changes from 40.5 to 100% depending on the group of animals under study. L'efficacité d'un nouveau vaccin inactivé contre la trichophytie du bétail a été étudiée sur des cobayes et des veaux dans des conditions expérimentales et sur 3 troupeaux de bétail dans des conditions de contagion naturelle. Le vaccin contenant la souche Trichophyton verrucosum a entraîné une nette réponse immunologique du type cellulaire. La réaction immunologique, appréciée à l'aide du test d'inhibition de migration du leucocytes etait en correlation avec l'immunité, déterminée par epreuve infestante. Dans les troupeaux où 30 à 67% d'animaux ont été infestés avec la souche T. verrucosum on a constaté après 4 semaines, après avoir reçu deux doses de vaccin, une diminution du nombre de'animaux présentant des symptômes cliniques de maladie dans la proposition de 40,5% a 100% par rapport au temoins.</description><subject>Age Factors</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>calves</subject><subject>Cattle</subject><subject>Cattle Diseases - prevention &amp; control</subject><subject>Cattle Diseases - therapy</subject><subject>Cell Migration Inhibition</subject><subject>Colostrum - immunology</subject><subject>delayed hypersensitivity test</subject><subject>Fungal Vaccines - immunology</subject><subject>Fungal Vaccines - therapeutic use</subject><subject>Guinea Pigs</subject><subject>Human mycoses</subject><subject>Hypersensitivity, Delayed - veterinary</subject><subject>immune response</subject><subject>Immunotherapy, Active - veterinary</subject><subject>inactivated vaccine</subject><subject>Infectious diseases</subject><subject>live vaccines</subject><subject>Medical sciences</subject><subject>migration inhibition test</subject><subject>Mycoses</subject><subject>Mycoses of the skin</subject><subject>prophylaxie</subject><subject>prophylaxis</subject><subject>ringworm</subject><subject>ringworm (trichophytosis)</subject><subject>Skin Tests - veterinary</subject><subject>test d'hypersensibilité tardive</subject><subject>test d'inhibition de migration</subject><subject>Tinea - prevention &amp; control</subject><subject>Tinea - therapy</subject><subject>Tinea - veterinary</subject><subject>traitement</subject><subject>treatment</subject><subject>trichophytie/trichophytosis</subject><subject>Trichophyton - immunology</subject><subject>Trichophyton verrucosum</subject><subject>vaccin inactivé</subject><subject>vaccination</subject><subject>Vaccination - veterinary</subject><subject>Vaccines, Inactivated - immunology</subject><subject>Vaccines, Inactivated - therapeutic use</subject><issn>0147-9571</issn><issn>1878-1667</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0UtPGzEQB3ALFdEU-g2oyAG1cFg6Y3sfvlRCvCUkDsDZmvUjMkp2wd4E8e3rdCO40ZMP85vR-D-M7SOcIGD1G1DWhSprPFL8WAEoVZxvsQk2dVNgVdVf2OSdfGXfUnqCjFDiDtvBUtYVqgn7ddpNQ0dmCCsanJ2uyJjQuSnNKHRpmMbQzV77uNhj257myX3fvLvs8fLi4ey6uL27ujk7vS2MlDgUFiyC8QTeEglqjARpy7ZynPsSWlk1ygvZgpVGEm-F8S1k7CTVCORI7LKf49zn2L8sXRr0IiTj5nPqXL9MuuaNaCou_guxwkaJWmYoR2hin1J0Xj_HsKD4phH0Oki9TkmvU9KK639B6vPc9mMzf9kunP1oGpPL9cNNnZKhuY_UmZDeWYmIosTMDkbmqdc0i5k83nNAATyfSML6I39G4XKsq-CiTia4zjgbojODtn34fNO_iLqXWQ</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>Wawrzkiewicz, K.</creator><creator>Wawrzkiewicz, J.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>1992</creationdate><title>An inactivated vaccine against ringworm</title><author>Wawrzkiewicz, K. ; Wawrzkiewicz, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-d0d10cfa0fdaa3a8c404d5b6e22f50b4689f34b0d4c4a2b3cfb0a0fe4a710aea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Age Factors</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>calves</topic><topic>Cattle</topic><topic>Cattle Diseases - prevention &amp; control</topic><topic>Cattle Diseases - therapy</topic><topic>Cell Migration Inhibition</topic><topic>Colostrum - immunology</topic><topic>delayed hypersensitivity test</topic><topic>Fungal Vaccines - immunology</topic><topic>Fungal Vaccines - therapeutic use</topic><topic>Guinea Pigs</topic><topic>Human mycoses</topic><topic>Hypersensitivity, Delayed - veterinary</topic><topic>immune response</topic><topic>Immunotherapy, Active - veterinary</topic><topic>inactivated vaccine</topic><topic>Infectious diseases</topic><topic>live vaccines</topic><topic>Medical sciences</topic><topic>migration inhibition test</topic><topic>Mycoses</topic><topic>Mycoses of the skin</topic><topic>prophylaxie</topic><topic>prophylaxis</topic><topic>ringworm</topic><topic>ringworm (trichophytosis)</topic><topic>Skin Tests - veterinary</topic><topic>test d'hypersensibilité tardive</topic><topic>test d'inhibition de migration</topic><topic>Tinea - prevention &amp; control</topic><topic>Tinea - therapy</topic><topic>Tinea - veterinary</topic><topic>traitement</topic><topic>treatment</topic><topic>trichophytie/trichophytosis</topic><topic>Trichophyton - immunology</topic><topic>Trichophyton verrucosum</topic><topic>vaccin inactivé</topic><topic>vaccination</topic><topic>Vaccination - veterinary</topic><topic>Vaccines, Inactivated - immunology</topic><topic>Vaccines, Inactivated - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wawrzkiewicz, K.</creatorcontrib><creatorcontrib>Wawrzkiewicz, J.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Comparative Immunology, Microbiology and Infectious Diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wawrzkiewicz, K.</au><au>Wawrzkiewicz, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An inactivated vaccine against ringworm</atitle><jtitle>Comparative Immunology, Microbiology and Infectious Diseases</jtitle><addtitle>Comp Immunol Microbiol Infect Dis</addtitle><date>1992</date><risdate>1992</risdate><volume>15</volume><issue>1</issue><spage>31</spage><epage>40</epage><pages>31-40</pages><issn>0147-9571</issn><eissn>1878-1667</eissn><coden>CIMIDV</coden><abstract>A new vaccine against ringworm, containing the inactivated Trichophyton verrucosum strain, was assessed on guinea pigs and calves under experimental conditions and on three herds of cattle under natural conditions. The vaccine elicited a distinct immune response of the cellular type. This type of immunity assessed by the migration inhibition test of leukocytes corresponded to the immunity evaluated by the challenge. In herds in which there were from 30 to 67% of naturally infected animals with T. verrucosum, two doses of the vaccine resulted in after 4 weeks a decrease of the number of animals with clinical changes from 40.5 to 100% depending on the group of animals under study. L'efficacité d'un nouveau vaccin inactivé contre la trichophytie du bétail a été étudiée sur des cobayes et des veaux dans des conditions expérimentales et sur 3 troupeaux de bétail dans des conditions de contagion naturelle. Le vaccin contenant la souche Trichophyton verrucosum a entraîné une nette réponse immunologique du type cellulaire. La réaction immunologique, appréciée à l'aide du test d'inhibition de migration du leucocytes etait en correlation avec l'immunité, déterminée par epreuve infestante. Dans les troupeaux où 30 à 67% d'animaux ont été infestés avec la souche T. verrucosum on a constaté après 4 semaines, après avoir reçu deux doses de vaccin, une diminution du nombre de'animaux présentant des symptômes cliniques de maladie dans la proposition de 40,5% a 100% par rapport au temoins.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>1547619</pmid><doi>10.1016/0147-9571(92)90099-D</doi><tpages>10</tpages></addata></record>
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subjects Age Factors
Animals
Biological and medical sciences
calves
Cattle
Cattle Diseases - prevention & control
Cattle Diseases - therapy
Cell Migration Inhibition
Colostrum - immunology
delayed hypersensitivity test
Fungal Vaccines - immunology
Fungal Vaccines - therapeutic use
Guinea Pigs
Human mycoses
Hypersensitivity, Delayed - veterinary
immune response
Immunotherapy, Active - veterinary
inactivated vaccine
Infectious diseases
live vaccines
Medical sciences
migration inhibition test
Mycoses
Mycoses of the skin
prophylaxie
prophylaxis
ringworm
ringworm (trichophytosis)
Skin Tests - veterinary
test d'hypersensibilité tardive
test d'inhibition de migration
Tinea - prevention & control
Tinea - therapy
Tinea - veterinary
traitement
treatment
trichophytie/trichophytosis
Trichophyton - immunology
Trichophyton verrucosum
vaccin inactivé
vaccination
Vaccination - veterinary
Vaccines, Inactivated - immunology
Vaccines, Inactivated - therapeutic use
title An inactivated vaccine against ringworm
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