An immunohistochemical study of perianal paget's disease. Possible origins and clinical implications
The histogenesis of perianal Paget's disease is controversial. A clinical and pathologic study was done of a patient with a history of adenocarcinoma of the rectum for whom a subsequent diagnosis of perianal Paget's disease was the sole manifestation of recurrent rectal cancer. Immunohisto...
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| Veröffentlicht in: | Cancer 1992-04, Vol.69 (8), p.2166-2171 |
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| creator | Miller, Larry R. McCunnif, Ann J. Randall, Marcus E. |
| description | The histogenesis of perianal Paget's disease is controversial. A clinical and pathologic study was done of a patient with a history of adenocarcinoma of the rectum for whom a subsequent diagnosis of perianal Paget's disease was the sole manifestation of recurrent rectal cancer. Immunohistochemical techniques were used to compare and contrast the original rectal adenocarcinoma with the subsequent perianal skin recurrence confined to the epidermis. Both the rectal adenocarcinoma and the Paget's cells were positive for cytokeratin, epithelial membrane antigen, B72.3, and carcinoembryonic antigen and negative for gross cystic disease fluid protein‐15, Leu‐M1, CA 125, and S‐100 protein. These findings, their relevance to the histogenesis of perianal Paget's disease, and the possible clinical implications are discussed. |
| doi_str_mv | 10.1002/1097-0142(19920415)69:8<2166::AID-CNCR2820690825>3.0.CO;2-E |
| format | Article |
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These findings, their relevance to the histogenesis of perianal Paget's disease, and the possible clinical implications are discussed.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/1097-0142(19920415)69:8<2166::AID-CNCR2820690825>3.0.CO;2-E</identifier><identifier>PMID: 1311986</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adenocarcinoma - chemistry ; Adenocarcinoma - pathology ; Aged ; Anus Neoplasms - chemistry ; Anus Neoplasms - pathology ; Biomarkers ; Female ; Humans ; Immunoenzyme Techniques ; Neoplasm Recurrence, Local - chemistry ; Neoplasm Recurrence, Local - pathology ; Paget Disease, Extramammary - chemistry ; Paget Disease, Extramammary - pathology ; Perineum ; Rectal Neoplasms - chemistry ; Rectal Neoplasms - pathology ; Skin Neoplasms - chemistry ; Skin Neoplasms - pathology</subject><ispartof>Cancer, 1992-04, Vol.69 (8), p.2166-2171</ispartof><rights>Copyright © 1992 American Cancer Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c5355-679bb20d4f651791ceaf8a4526073e461826655d85dfdde1a6702ac3121977303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1311986$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miller, Larry R.</creatorcontrib><creatorcontrib>McCunnif, Ann J.</creatorcontrib><creatorcontrib>Randall, Marcus E.</creatorcontrib><title>An immunohistochemical study of perianal paget's disease. Possible origins and clinical implications</title><title>Cancer</title><addtitle>Cancer</addtitle><description>The histogenesis of perianal Paget's disease is controversial. A clinical and pathologic study was done of a patient with a history of adenocarcinoma of the rectum for whom a subsequent diagnosis of perianal Paget's disease was the sole manifestation of recurrent rectal cancer. Immunohistochemical techniques were used to compare and contrast the original rectal adenocarcinoma with the subsequent perianal skin recurrence confined to the epidermis. Both the rectal adenocarcinoma and the Paget's cells were positive for cytokeratin, epithelial membrane antigen, B72.3, and carcinoembryonic antigen and negative for gross cystic disease fluid protein‐15, Leu‐M1, CA 125, and S‐100 protein. These findings, their relevance to the histogenesis of perianal Paget's disease, and the possible clinical implications are discussed.</description><subject>Adenocarcinoma - chemistry</subject><subject>Adenocarcinoma - pathology</subject><subject>Aged</subject><subject>Anus Neoplasms - chemistry</subject><subject>Anus Neoplasms - pathology</subject><subject>Biomarkers</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Neoplasm Recurrence, Local - chemistry</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Paget Disease, Extramammary - chemistry</subject><subject>Paget Disease, Extramammary - pathology</subject><subject>Perineum</subject><subject>Rectal Neoplasms - chemistry</subject><subject>Rectal Neoplasms - pathology</subject><subject>Skin Neoplasms - chemistry</subject><subject>Skin Neoplasms - pathology</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkVuLFDEQhYMo6-zqTxDypO5Dj0mlc5sVYWhHXVgcEQXBhyLTSe9G-manG5l_b4-zKvog-JSkTuVUcj5CCs6WnDF4xpnVGeM5POXWAsu5PFd2ZZ4DV2q1Wl--zIq3xXswwJRlBuQLsWTLYnsB2eYOWfy6fZcsGGMmk7n4dJ-cpvRlPmqQ4oSccMG5NWpB_LqlsWmmtruJaezKm9DE0tU0jZPf066ifRiia-dK767D-CRRH1NwKSzpuy6luKsD7YZ4HdtEXetpWcf2h0Fs-nrejLFr0wNyr3J1Cg9v1zPy8dXmQ_Emu9q-vizWV1kphZSZ0na3A-bzSkmuLS-Dq4zLJSimRcgVN6CUlN5IX3kfuFOagSsFB261FkyckcdH337ovk4hjdjEVIa6dm3opoQajFCgYG78fGwsh_kTQ6iwH2Ljhj1yhgcGeEgRDyniTwaoLBo8MECcGeCfDFAgw2KLgJvZ_dHtM6ZdE_xv72Pos14d9W-xDvv_G_3PyX8p4jt9RKRv</recordid><startdate>19920415</startdate><enddate>19920415</enddate><creator>Miller, Larry R.</creator><creator>McCunnif, Ann J.</creator><creator>Randall, Marcus E.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19920415</creationdate><title>An immunohistochemical study of perianal paget's disease. Possible origins and clinical implications</title><author>Miller, Larry R. ; McCunnif, Ann J. ; Randall, Marcus E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5355-679bb20d4f651791ceaf8a4526073e461826655d85dfdde1a6702ac3121977303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adenocarcinoma - chemistry</topic><topic>Adenocarcinoma - pathology</topic><topic>Aged</topic><topic>Anus Neoplasms - chemistry</topic><topic>Anus Neoplasms - pathology</topic><topic>Biomarkers</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Neoplasm Recurrence, Local - chemistry</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Paget Disease, Extramammary - chemistry</topic><topic>Paget Disease, Extramammary - pathology</topic><topic>Perineum</topic><topic>Rectal Neoplasms - chemistry</topic><topic>Rectal Neoplasms - pathology</topic><topic>Skin Neoplasms - chemistry</topic><topic>Skin Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miller, Larry R.</creatorcontrib><creatorcontrib>McCunnif, Ann J.</creatorcontrib><creatorcontrib>Randall, Marcus E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miller, Larry R.</au><au>McCunnif, Ann J.</au><au>Randall, Marcus E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An immunohistochemical study of perianal paget's disease. Possible origins and clinical implications</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>1992-04-15</date><risdate>1992</risdate><volume>69</volume><issue>8</issue><spage>2166</spage><epage>2171</epage><pages>2166-2171</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><abstract>The histogenesis of perianal Paget's disease is controversial. A clinical and pathologic study was done of a patient with a history of adenocarcinoma of the rectum for whom a subsequent diagnosis of perianal Paget's disease was the sole manifestation of recurrent rectal cancer. Immunohistochemical techniques were used to compare and contrast the original rectal adenocarcinoma with the subsequent perianal skin recurrence confined to the epidermis. Both the rectal adenocarcinoma and the Paget's cells were positive for cytokeratin, epithelial membrane antigen, B72.3, and carcinoembryonic antigen and negative for gross cystic disease fluid protein‐15, Leu‐M1, CA 125, and S‐100 protein. These findings, their relevance to the histogenesis of perianal Paget's disease, and the possible clinical implications are discussed.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>1311986</pmid><doi>10.1002/1097-0142(19920415)69:8<2166::AID-CNCR2820690825>3.0.CO;2-E</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cancer, 1992-04, Vol.69 (8), p.2166-2171 |
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| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adenocarcinoma - chemistry Adenocarcinoma - pathology Aged Anus Neoplasms - chemistry Anus Neoplasms - pathology Biomarkers Female Humans Immunoenzyme Techniques Neoplasm Recurrence, Local - chemistry Neoplasm Recurrence, Local - pathology Paget Disease, Extramammary - chemistry Paget Disease, Extramammary - pathology Perineum Rectal Neoplasms - chemistry Rectal Neoplasms - pathology Skin Neoplasms - chemistry Skin Neoplasms - pathology |
| title | An immunohistochemical study of perianal paget's disease. Possible origins and clinical implications |
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