Benzazepinone calcium channel blockers. 4. Structure-activity overview and intracellular binding site

We have synthesized a series of benzazepinones (2) in order to determine the structure-activity relationships (SAR) for calcium channel blockers related to diltiazem. A prerequisite for calcium channel blocking activity in vitro and in vivo is the presence of two pharmacophores: a 4'-aryl methy...

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Veröffentlicht in:	Journal of medicinal chemistry 1992-02, Vol.35 (4), p.780-793
Hauptverfasser:	Kimball, S. David, Floyd, David M, Das, Jagabandhu, Hunt, John T, Krapcho, John, Rovnyak, George, Duff, Keith J, Lee, Ving G, Moquin, Robert V
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzazepines - chemistry Benzazepines - metabolism Binding Sites Calcium Channel Blockers - chemistry Calcium Channel Blockers - metabolism Calcium Channels - metabolism Cell Membrane - metabolism Chemical Phenomena Chemistry, Physical Diltiazem - analogs & derivatives Molecular Structure Structure-Activity Relationship
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