Modification of respiratory function parameters in patients with severe Parkinson's disease
Respiratory dysfunction remains one of the most common causes of death in patients with complicated Parkinson's disease (PD). The aim of this study was to investigate pulmonary function in fluctuating PD patients during "on" and "off" states of the disease. We studied 12 flu...
Gespeichert in:
| Veröffentlicht in: | Neurological sciences 2002-09, Vol.23 Suppl 2, p.S69-s70 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | s70 |
|---|---|
| container_issue | |
| container_start_page | S69 |
| container_title | Neurological sciences |
| container_volume | 23 Suppl 2 |
| creator | De Pandis, M F Starace, A Stefanelli, F Marruzzo, P Meoli, I De Simone, G Prati, R Stocchi, F |
| description | Respiratory dysfunction remains one of the most common causes of death in patients with complicated Parkinson's disease (PD). The aim of this study was to investigate pulmonary function in fluctuating PD patients during "on" and "off" states of the disease. We studied 12 fluctuating, non-smoking PD patients (H&Y stages 3-5) without a history of lung or cardiovascular disease; all patients underwent Hoehn and Yahr scale (H&Y) and Unified Parkinson Disease Rating Scale (UPDRS items 18-31) to evaluate extrapyramidal impairment, as well as pulmonary function tests (PFT) and arterial blood gas analyses to assess respiratory function. All evaluations were performed during a stable on state of disease and in an off state produced by 12 hours of therapy withdrawal. A restrictive pattern of flow-volume loop was observed both in on and off states of disease. In the off state, we found a significant worsening in both FEV1 and FVC; the FEV1/FVC ratio was unmodified. These results suggest a restrictive pattern of flow-volume loop in these patients. |
| doi_str_mv | 10.1007/s100720200074 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72835938</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>712975441</sourcerecordid><originalsourceid>FETCH-LOGICAL-c316t-47bd6c1fcb4531a399d5ac4d6dc32bb93d8ca6eda35fd905e95d2a7c96a755523</originalsourceid><addsrcrecordid>eNpdkM1Lw0AQxRdRbK0evUrwoKdo9ivZPUrxCyp60JOHsNmd4NY2W3cSpf-9iS2IXubNDD8ej0fIMc0uaJYVlzhMlrGsF7FDxlTqLOWiULvbnapCjMgB4rxHqKB8n4wok0Jxocbk9SE4X3trWh-aJNRJBFz5aNoQ10ndNfbnvzLRLKGFiIkfrtZD02Ly5du3BOETIiRPJr77BkNzjonzCAbhkOzVZoFwtNUJebm5fp7epbPH2_vp1Sy1nOZtKorK5ZbWthKSU8O1dtJY4XJnOasqzZ2yJgdnuKydziRo6ZgprM5NIaVkfELONr6rGD46wLZcerSwWJgGQodlwRSXmqsePP0HzkMXmz5byajKFdN0cEs3kI0BMUJdrqJfmrguaVYOZZd_Ku_5k61pVy3B_dLbjvk3CYh87A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>218682912</pqid></control><display><type>article</type><title>Modification of respiratory function parameters in patients with severe Parkinson's disease</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>De Pandis, M F ; Starace, A ; Stefanelli, F ; Marruzzo, P ; Meoli, I ; De Simone, G ; Prati, R ; Stocchi, F</creator><creatorcontrib>De Pandis, M F ; Starace, A ; Stefanelli, F ; Marruzzo, P ; Meoli, I ; De Simone, G ; Prati, R ; Stocchi, F</creatorcontrib><description>Respiratory dysfunction remains one of the most common causes of death in patients with complicated Parkinson's disease (PD). The aim of this study was to investigate pulmonary function in fluctuating PD patients during "on" and "off" states of the disease. We studied 12 fluctuating, non-smoking PD patients (H&Y stages 3-5) without a history of lung or cardiovascular disease; all patients underwent Hoehn and Yahr scale (H&Y) and Unified Parkinson Disease Rating Scale (UPDRS items 18-31) to evaluate extrapyramidal impairment, as well as pulmonary function tests (PFT) and arterial blood gas analyses to assess respiratory function. All evaluations were performed during a stable on state of disease and in an off state produced by 12 hours of therapy withdrawal. A restrictive pattern of flow-volume loop was observed both in on and off states of disease. In the off state, we found a significant worsening in both FEV1 and FVC; the FEV1/FVC ratio was unmodified. These results suggest a restrictive pattern of flow-volume loop in these patients.</description><identifier>ISSN: 1590-1874</identifier><identifier>EISSN: 1590-3478</identifier><identifier>DOI: 10.1007/s100720200074</identifier><identifier>PMID: 12548348</identifier><language>eng</language><publisher>Italy: Springer Nature B.V</publisher><subject>Aged ; Female ; Humans ; Male ; Middle Aged ; Neurology ; Neurosciences ; Parkinson Disease - complications ; Parkinson Disease - physiopathology ; Parkinson's disease ; Pulmonary Ventilation ; Respiratory Function Tests ; Respiratory Insufficiency - etiology ; Respiratory Insufficiency - physiopathology ; Severity of Illness Index</subject><ispartof>Neurological sciences, 2002-09, Vol.23 Suppl 2, p.S69-s70</ispartof><rights>Copyright Springer-Verlag 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c316t-47bd6c1fcb4531a399d5ac4d6dc32bb93d8ca6eda35fd905e95d2a7c96a755523</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12548348$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>De Pandis, M F</creatorcontrib><creatorcontrib>Starace, A</creatorcontrib><creatorcontrib>Stefanelli, F</creatorcontrib><creatorcontrib>Marruzzo, P</creatorcontrib><creatorcontrib>Meoli, I</creatorcontrib><creatorcontrib>De Simone, G</creatorcontrib><creatorcontrib>Prati, R</creatorcontrib><creatorcontrib>Stocchi, F</creatorcontrib><title>Modification of respiratory function parameters in patients with severe Parkinson's disease</title><title>Neurological sciences</title><addtitle>Neurol Sci</addtitle><description>Respiratory dysfunction remains one of the most common causes of death in patients with complicated Parkinson's disease (PD). The aim of this study was to investigate pulmonary function in fluctuating PD patients during "on" and "off" states of the disease. We studied 12 fluctuating, non-smoking PD patients (H&Y stages 3-5) without a history of lung or cardiovascular disease; all patients underwent Hoehn and Yahr scale (H&Y) and Unified Parkinson Disease Rating Scale (UPDRS items 18-31) to evaluate extrapyramidal impairment, as well as pulmonary function tests (PFT) and arterial blood gas analyses to assess respiratory function. All evaluations were performed during a stable on state of disease and in an off state produced by 12 hours of therapy withdrawal. A restrictive pattern of flow-volume loop was observed both in on and off states of disease. In the off state, we found a significant worsening in both FEV1 and FVC; the FEV1/FVC ratio was unmodified. These results suggest a restrictive pattern of flow-volume loop in these patients.</description><subject>Aged</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Parkinson Disease - complications</subject><subject>Parkinson Disease - physiopathology</subject><subject>Parkinson's disease</subject><subject>Pulmonary Ventilation</subject><subject>Respiratory Function Tests</subject><subject>Respiratory Insufficiency - etiology</subject><subject>Respiratory Insufficiency - physiopathology</subject><subject>Severity of Illness Index</subject><issn>1590-1874</issn><issn>1590-3478</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkM1Lw0AQxRdRbK0evUrwoKdo9ivZPUrxCyp60JOHsNmd4NY2W3cSpf-9iS2IXubNDD8ej0fIMc0uaJYVlzhMlrGsF7FDxlTqLOWiULvbnapCjMgB4rxHqKB8n4wok0Jxocbk9SE4X3trWh-aJNRJBFz5aNoQ10ndNfbnvzLRLKGFiIkfrtZD02Ly5du3BOETIiRPJr77BkNzjonzCAbhkOzVZoFwtNUJebm5fp7epbPH2_vp1Sy1nOZtKorK5ZbWthKSU8O1dtJY4XJnOasqzZ2yJgdnuKydziRo6ZgprM5NIaVkfELONr6rGD46wLZcerSwWJgGQodlwRSXmqsePP0HzkMXmz5byajKFdN0cEs3kI0BMUJdrqJfmrguaVYOZZd_Ku_5k61pVy3B_dLbjvk3CYh87A</recordid><startdate>200209</startdate><enddate>200209</enddate><creator>De Pandis, M F</creator><creator>Starace, A</creator><creator>Stefanelli, F</creator><creator>Marruzzo, P</creator><creator>Meoli, I</creator><creator>De Simone, G</creator><creator>Prati, R</creator><creator>Stocchi, F</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>200209</creationdate><title>Modification of respiratory function parameters in patients with severe Parkinson's disease</title><author>De Pandis, M F ; Starace, A ; Stefanelli, F ; Marruzzo, P ; Meoli, I ; De Simone, G ; Prati, R ; Stocchi, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c316t-47bd6c1fcb4531a399d5ac4d6dc32bb93d8ca6eda35fd905e95d2a7c96a755523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Aged</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Parkinson Disease - complications</topic><topic>Parkinson Disease - physiopathology</topic><topic>Parkinson's disease</topic><topic>Pulmonary Ventilation</topic><topic>Respiratory Function Tests</topic><topic>Respiratory Insufficiency - etiology</topic><topic>Respiratory Insufficiency - physiopathology</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>De Pandis, M F</creatorcontrib><creatorcontrib>Starace, A</creatorcontrib><creatorcontrib>Stefanelli, F</creatorcontrib><creatorcontrib>Marruzzo, P</creatorcontrib><creatorcontrib>Meoli, I</creatorcontrib><creatorcontrib>De Simone, G</creatorcontrib><creatorcontrib>Prati, R</creatorcontrib><creatorcontrib>Stocchi, F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>De Pandis, M F</au><au>Starace, A</au><au>Stefanelli, F</au><au>Marruzzo, P</au><au>Meoli, I</au><au>De Simone, G</au><au>Prati, R</au><au>Stocchi, F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modification of respiratory function parameters in patients with severe Parkinson's disease</atitle><jtitle>Neurological sciences</jtitle><addtitle>Neurol Sci</addtitle><date>2002-09</date><risdate>2002</risdate><volume>23 Suppl 2</volume><spage>S69</spage><epage>s70</epage><pages>S69-s70</pages><issn>1590-1874</issn><eissn>1590-3478</eissn><abstract>Respiratory dysfunction remains one of the most common causes of death in patients with complicated Parkinson's disease (PD). The aim of this study was to investigate pulmonary function in fluctuating PD patients during "on" and "off" states of the disease. We studied 12 fluctuating, non-smoking PD patients (H&Y stages 3-5) without a history of lung or cardiovascular disease; all patients underwent Hoehn and Yahr scale (H&Y) and Unified Parkinson Disease Rating Scale (UPDRS items 18-31) to evaluate extrapyramidal impairment, as well as pulmonary function tests (PFT) and arterial blood gas analyses to assess respiratory function. All evaluations were performed during a stable on state of disease and in an off state produced by 12 hours of therapy withdrawal. A restrictive pattern of flow-volume loop was observed both in on and off states of disease. In the off state, we found a significant worsening in both FEV1 and FVC; the FEV1/FVC ratio was unmodified. These results suggest a restrictive pattern of flow-volume loop in these patients.</abstract><cop>Italy</cop><pub>Springer Nature B.V</pub><pmid>12548348</pmid><doi>10.1007/s100720200074</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1590-1874 |
| ispartof | Neurological sciences, 2002-09, Vol.23 Suppl 2, p.S69-s70 |
| issn | 1590-1874 1590-3478 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72835938 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Aged Female Humans Male Middle Aged Neurology Neurosciences Parkinson Disease - complications Parkinson Disease - physiopathology Parkinson's disease Pulmonary Ventilation Respiratory Function Tests Respiratory Insufficiency - etiology Respiratory Insufficiency - physiopathology Severity of Illness Index |
| title | Modification of respiratory function parameters in patients with severe Parkinson's disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T20%3A30%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Modification%20of%20respiratory%20function%20parameters%20in%20patients%20with%20severe%20Parkinson's%20disease&rft.jtitle=Neurological%20sciences&rft.au=De%20Pandis,%20M%20F&rft.date=2002-09&rft.volume=23%20Suppl%202&rft.spage=S69&rft.epage=s70&rft.pages=S69-s70&rft.issn=1590-1874&rft.eissn=1590-3478&rft_id=info:doi/10.1007/s100720200074&rft_dat=%3Cproquest_cross%3E712975441%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=218682912&rft_id=info:pmid/12548348&rfr_iscdi=true |