A single dose of oral DNA immunization delivered by attenuated Salmonella typhimurium down‐regulates transgene expression in HBsAg transgenic mice

The efficacy of immunization with Salmonella typhimurium aroA to deliver the plasmid pRc/CMV‐HBsAg (i.e. an oral DNA vaccine) was compared with that of intramuscular immunization with the same plasmid DNA, and with recombinant HBsAg protein, in a HBsAg transgenic mouse model. A single dose of oral D...

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Veröffentlicht in:	European journal of immunology 2002-11, Vol.32 (11), p.3294-3304
Hauptverfasser:	Zheng, Bo Jian, Ng, Mun Hon, Chan, Kwok Wah, Tam, Sidney, Woo, Patrick C. Y., Ng, Sze Park, Yuen, Kwok Yung
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Down-Regulation Female Gene Expression Regulation Hepatitis B Antibodies - biosynthesis Hepatitis B Surface Antigens - genetics Hepatitis B Surface Antigens - immunology Hepatitis B Vaccines - administration & dosage Immunization Inhibition of HBV transgene Liver - pathology Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Transgenic Oral DNA vaccination Salmonella typhimurium - genetics T cell immunity T-Lymphocytes, Cytotoxic - immunology Th1 Cells - immunology Transcription, Genetic Transgenes Vaccines, DNA - immunology
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