Detection of Human Viruses in Patients With Chronic Periodontitis and the Relationship Between Viruses and Clinical Parameters
Background: Recent studies have demonstrated that various human viruses, especially cytomegalovirus (HCMV), Epstein‐Barr virus type‐1 (EBV‐1), and herpes simplex virus (HSV), seem to play a part in the pathogenesis of human periodontitis. Little information is available on the relationship between t...
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| Veröffentlicht in: | Journal of periodontology (1970) 2002-12, Vol.73 (12), p.1437-1443 |
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| container_title | Journal of periodontology (1970) |
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| creator | Saygun, Işil Şahin, Sermet Özdemir, Atilla Kurtiş, Bülent Yapar, Mehmet Kubar, Ayhan Özcan, Gönen |
| description | Background: Recent studies have demonstrated that various human viruses, especially cytomegalovirus (HCMV), Epstein‐Barr virus type‐1 (EBV‐1), and herpes simplex virus (HSV), seem to play a part in the pathogenesis of human periodontitis. Little information is available on the relationship between these viruses and clinical periodontal parameters in patients with chronic periodontitis. This study examined the occurrence of HCMV, EBV‐1, and HSV in patients with chronic periodontitis and the relationship between these viruses and clinical parameters.
Methods: A nested polymerase chain reaction (PCR) method determined the presence of HCMV, EBV‐1, and HSV. Subgingival plaque samples from 30 patients with chronic periodontitis and 21 randomly selected healthy controls were collected by paper points, and clinical measurements were recorded from both sampling sites and entire dentition. The following indices were measured: plaque index (PI), gingival index (GI), probing depth (PD), and clinical attachment loss (CAL).
Results: HCMV was detected in 44.3% of chronic periodontitis patients and 14.3% of healthy persons (P |
| doi_str_mv | 10.1902/jop.2002.73.12.1437 |
| format | Article |
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Methods: A nested polymerase chain reaction (PCR) method determined the presence of HCMV, EBV‐1, and HSV. Subgingival plaque samples from 30 patients with chronic periodontitis and 21 randomly selected healthy controls were collected by paper points, and clinical measurements were recorded from both sampling sites and entire dentition. The following indices were measured: plaque index (PI), gingival index (GI), probing depth (PD), and clinical attachment loss (CAL).
Results: HCMV was detected in 44.3% of chronic periodontitis patients and 14.3% of healthy persons (P <0.05); EBV‐1 in 16.7% of chronic periodontitis patients and 14.3% of healthy persons (P = 1.00); and HSV in 6.7% of chronic periodontitis patients and in no healthy persons. HCMV and EBV‐1 detected and undetected sites in patients with periodontitis showed statistically significant differences in sampling clinical depth (SPD) and sampling clinical attachment loss (SCAL). Differences in the measurements of PI of entire dentition and GI of entire dentition between HSV detected and undetected sites were statistically significant.
Conclusions: Findings of the present study confirm the frequent presence of HCMV in crevicular samples of chronic periodontitis lesions, and suggest a strong relationship between the presence of HCMV and EBV‐1 in subgingival areas and the measurements of probing depth and probing attachment loss. J Periodontol 2002;73:1437‐1443.</description><identifier>ISSN: 0022-3492</identifier><identifier>EISSN: 1943-3670</identifier><identifier>DOI: 10.1902/jop.2002.73.12.1437</identifier><identifier>PMID: 12546093</identifier><language>eng</language><publisher>737 N. Michigan Avenue, Suite 800, Chicago, IL 60611‐2690, USA: American Academy of Periodontology</publisher><subject>Adult ; Case-Control Studies ; Chi-Square Distribution ; Chronic Disease ; Cytomegalovirus ; Cytomegalovirus - isolation & purification ; Dental Plaque - virology ; Dental Plaque Index ; Dentistry ; DNA, Viral - analysis ; Epstein‐Barr virus ; Female ; herpes simplex virus ; Herpesvirus 1, Human - isolation & purification ; Herpesvirus 4, Human - isolation & purification ; Humans ; Male ; Middle Aged ; periodontal attachment loss ; Periodontal Attachment Loss - virology ; Periodontal Index ; periodontal probes ; Periodontitis - virology ; periodontitis/pathogenesis ; Statistics, Nonparametric</subject><ispartof>Journal of periodontology (1970), 2002-12, Vol.73 (12), p.1437-1443</ispartof><rights>2002 American Academy of Periodontology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3517-d5ec7c5636a2858c59427c311ad3f7301d4040a6131f57fdf6e4d22839c310123</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1902%2Fjop.2002.73.12.1437$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1902%2Fjop.2002.73.12.1437$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27922,27923,45572,45573</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12546093$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saygun, Işil</creatorcontrib><creatorcontrib>Şahin, Sermet</creatorcontrib><creatorcontrib>Özdemir, Atilla</creatorcontrib><creatorcontrib>Kurtiş, Bülent</creatorcontrib><creatorcontrib>Yapar, Mehmet</creatorcontrib><creatorcontrib>Kubar, Ayhan</creatorcontrib><creatorcontrib>Özcan, Gönen</creatorcontrib><title>Detection of Human Viruses in Patients With Chronic Periodontitis and the Relationship Between Viruses and Clinical Parameters</title><title>Journal of periodontology (1970)</title><addtitle>J Periodontol</addtitle><description>Background: Recent studies have demonstrated that various human viruses, especially cytomegalovirus (HCMV), Epstein‐Barr virus type‐1 (EBV‐1), and herpes simplex virus (HSV), seem to play a part in the pathogenesis of human periodontitis. Little information is available on the relationship between these viruses and clinical periodontal parameters in patients with chronic periodontitis. This study examined the occurrence of HCMV, EBV‐1, and HSV in patients with chronic periodontitis and the relationship between these viruses and clinical parameters.
Methods: A nested polymerase chain reaction (PCR) method determined the presence of HCMV, EBV‐1, and HSV. Subgingival plaque samples from 30 patients with chronic periodontitis and 21 randomly selected healthy controls were collected by paper points, and clinical measurements were recorded from both sampling sites and entire dentition. The following indices were measured: plaque index (PI), gingival index (GI), probing depth (PD), and clinical attachment loss (CAL).
Results: HCMV was detected in 44.3% of chronic periodontitis patients and 14.3% of healthy persons (P <0.05); EBV‐1 in 16.7% of chronic periodontitis patients and 14.3% of healthy persons (P = 1.00); and HSV in 6.7% of chronic periodontitis patients and in no healthy persons. HCMV and EBV‐1 detected and undetected sites in patients with periodontitis showed statistically significant differences in sampling clinical depth (SPD) and sampling clinical attachment loss (SCAL). Differences in the measurements of PI of entire dentition and GI of entire dentition between HSV detected and undetected sites were statistically significant.
Conclusions: Findings of the present study confirm the frequent presence of HCMV in crevicular samples of chronic periodontitis lesions, and suggest a strong relationship between the presence of HCMV and EBV‐1 in subgingival areas and the measurements of probing depth and probing attachment loss. J Periodontol 2002;73:1437‐1443.</description><subject>Adult</subject><subject>Case-Control Studies</subject><subject>Chi-Square Distribution</subject><subject>Chronic Disease</subject><subject>Cytomegalovirus</subject><subject>Cytomegalovirus - isolation & purification</subject><subject>Dental Plaque - virology</subject><subject>Dental Plaque Index</subject><subject>Dentistry</subject><subject>DNA, Viral - analysis</subject><subject>Epstein‐Barr virus</subject><subject>Female</subject><subject>herpes simplex virus</subject><subject>Herpesvirus 1, Human - isolation & purification</subject><subject>Herpesvirus 4, Human - isolation & purification</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>periodontal attachment loss</subject><subject>Periodontal Attachment Loss - virology</subject><subject>Periodontal Index</subject><subject>periodontal probes</subject><subject>Periodontitis - virology</subject><subject>periodontitis/pathogenesis</subject><subject>Statistics, Nonparametric</subject><issn>0022-3492</issn><issn>1943-3670</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1r2zAch8VYWdK0n2AwdNrNnl6t-LilbyuFhtKXo9Dkv4mCbWWSTMmln73yEuh1JyH0_B7Bg9BXSkpaE_Zj63clI4SVipeUlVRw9QnNaS14wStFPqN5fmQFFzWbodMYt_maIfIFzSiToiI1n6O3C0hgk_MD9i2-GXsz4GcXxggRuwGvTXIwpIhfXNrg1Sb4wVm8huB844fkkovYDA1OG8AP0JlJFDduh39BegX4cE3QqnN5bbpsDabP_4Z4hk5a00U4P54L9HR1-bi6Ke7ur3-vft4VlkuqikaCVVZWvDJsKZdW1oIpyyk1DW8VJ7QRRBBTUU5bqdqmrUA0jC15nSFCGV-g7wfvLvi_I8SkexctdJ0ZwI9Rq8wSIWUG-QG0wccYoNW74HoT9poSPWXXObuesmvFNWV6yp5X34768U8Pzcfm2DkD9QF4dR3s_8epb9eXD__k751MkK8</recordid><startdate>200212</startdate><enddate>200212</enddate><creator>Saygun, Işil</creator><creator>Şahin, Sermet</creator><creator>Özdemir, Atilla</creator><creator>Kurtiş, Bülent</creator><creator>Yapar, Mehmet</creator><creator>Kubar, Ayhan</creator><creator>Özcan, Gönen</creator><general>American Academy of Periodontology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200212</creationdate><title>Detection of Human Viruses in Patients With Chronic Periodontitis and the Relationship Between Viruses and Clinical Parameters</title><author>Saygun, Işil ; Şahin, Sermet ; Özdemir, Atilla ; Kurtiş, Bülent ; Yapar, Mehmet ; Kubar, Ayhan ; Özcan, Gönen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3517-d5ec7c5636a2858c59427c311ad3f7301d4040a6131f57fdf6e4d22839c310123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Case-Control Studies</topic><topic>Chi-Square Distribution</topic><topic>Chronic Disease</topic><topic>Cytomegalovirus</topic><topic>Cytomegalovirus - isolation & purification</topic><topic>Dental Plaque - virology</topic><topic>Dental Plaque Index</topic><topic>Dentistry</topic><topic>DNA, Viral - analysis</topic><topic>Epstein‐Barr virus</topic><topic>Female</topic><topic>herpes simplex virus</topic><topic>Herpesvirus 1, Human - isolation & purification</topic><topic>Herpesvirus 4, Human - isolation & purification</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>periodontal attachment loss</topic><topic>Periodontal Attachment Loss - virology</topic><topic>Periodontal Index</topic><topic>periodontal probes</topic><topic>Periodontitis - virology</topic><topic>periodontitis/pathogenesis</topic><topic>Statistics, Nonparametric</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saygun, Işil</creatorcontrib><creatorcontrib>Şahin, Sermet</creatorcontrib><creatorcontrib>Özdemir, Atilla</creatorcontrib><creatorcontrib>Kurtiş, Bülent</creatorcontrib><creatorcontrib>Yapar, Mehmet</creatorcontrib><creatorcontrib>Kubar, Ayhan</creatorcontrib><creatorcontrib>Özcan, Gönen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of periodontology (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saygun, Işil</au><au>Şahin, Sermet</au><au>Özdemir, Atilla</au><au>Kurtiş, Bülent</au><au>Yapar, Mehmet</au><au>Kubar, Ayhan</au><au>Özcan, Gönen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Detection of Human Viruses in Patients With Chronic Periodontitis and the Relationship Between Viruses and Clinical Parameters</atitle><jtitle>Journal of periodontology (1970)</jtitle><addtitle>J Periodontol</addtitle><date>2002-12</date><risdate>2002</risdate><volume>73</volume><issue>12</issue><spage>1437</spage><epage>1443</epage><pages>1437-1443</pages><issn>0022-3492</issn><eissn>1943-3670</eissn><abstract>Background: Recent studies have demonstrated that various human viruses, especially cytomegalovirus (HCMV), Epstein‐Barr virus type‐1 (EBV‐1), and herpes simplex virus (HSV), seem to play a part in the pathogenesis of human periodontitis. Little information is available on the relationship between these viruses and clinical periodontal parameters in patients with chronic periodontitis. This study examined the occurrence of HCMV, EBV‐1, and HSV in patients with chronic periodontitis and the relationship between these viruses and clinical parameters.
Methods: A nested polymerase chain reaction (PCR) method determined the presence of HCMV, EBV‐1, and HSV. Subgingival plaque samples from 30 patients with chronic periodontitis and 21 randomly selected healthy controls were collected by paper points, and clinical measurements were recorded from both sampling sites and entire dentition. The following indices were measured: plaque index (PI), gingival index (GI), probing depth (PD), and clinical attachment loss (CAL).
Results: HCMV was detected in 44.3% of chronic periodontitis patients and 14.3% of healthy persons (P <0.05); EBV‐1 in 16.7% of chronic periodontitis patients and 14.3% of healthy persons (P = 1.00); and HSV in 6.7% of chronic periodontitis patients and in no healthy persons. HCMV and EBV‐1 detected and undetected sites in patients with periodontitis showed statistically significant differences in sampling clinical depth (SPD) and sampling clinical attachment loss (SCAL). Differences in the measurements of PI of entire dentition and GI of entire dentition between HSV detected and undetected sites were statistically significant.
Conclusions: Findings of the present study confirm the frequent presence of HCMV in crevicular samples of chronic periodontitis lesions, and suggest a strong relationship between the presence of HCMV and EBV‐1 in subgingival areas and the measurements of probing depth and probing attachment loss. J Periodontol 2002;73:1437‐1443.</abstract><cop>737 N. Michigan Avenue, Suite 800, Chicago, IL 60611‐2690, USA</cop><pub>American Academy of Periodontology</pub><pmid>12546093</pmid><doi>10.1902/jop.2002.73.12.1437</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0022-3492 |
| ispartof | Journal of periodontology (1970), 2002-12, Vol.73 (12), p.1437-1443 |
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| subjects | Adult Case-Control Studies Chi-Square Distribution Chronic Disease Cytomegalovirus Cytomegalovirus - isolation & purification Dental Plaque - virology Dental Plaque Index Dentistry DNA, Viral - analysis Epstein‐Barr virus Female herpes simplex virus Herpesvirus 1, Human - isolation & purification Herpesvirus 4, Human - isolation & purification Humans Male Middle Aged periodontal attachment loss Periodontal Attachment Loss - virology Periodontal Index periodontal probes Periodontitis - virology periodontitis/pathogenesis Statistics, Nonparametric |
| title | Detection of Human Viruses in Patients With Chronic Periodontitis and the Relationship Between Viruses and Clinical Parameters |
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