BCR/ABL amplification in chronic myelocytic leukemia blast crisis following imatinib mesylate administration

The onset of accelerated phase or blast crisis of chronic myelocytic leukemia (CML) is usually associated with the acquisition of new chromosome abnormalities in addition to the t(9;22)(q34;q11) that is characteristic of the chronic phase CML. We describe the cytogenetic and molecular genetic findin...

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Veröffentlicht in:	Cancer genetics and cytogenetics 2002-11, Vol.139 (1), p.30-33
Hauptverfasser:	Campbell, Lynda J., Patsouris, Crisoula, Rayeroux, Kathleen C., Somana, Kathy, Januszewicz, E.Henry, Szer, Jeffrey
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic agents Antineoplastic Agents - therapeutic use Benzamides Biological and medical sciences Blast Crisis - genetics Bone Marrow Cells - pathology Chemotherapy Chromosome Banding Fusion Proteins, bcr-abl - genetics Gene Amplification Humans Imatinib Mesylate Karyotyping Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology Male Medical sciences Pharmacology. Drug treatments Piperazines - therapeutic use Pyrimidines - therapeutic use
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